Gooseberry anthocyanins protect mice hepatic fibrosis by inhibiting TGF-β/Smad pathway

Gao, Jun; Yang, Jing; Wang, Yu; Hao, Ruobing; Fan, Jie; Wei, Jie

doi:10.1016/j.fbio.2020.100717

Cited by 9 publications

(8 citation statements)

References 28 publications

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“…TGF-β is the most fibrogenic cytokine in the liver [ 63 , 64 ] and contains three subtypes: TGF-β1, TGF-β2, and TGF-β3 [ 65 ]. Under the stimulation of TGF-β, HSCs start to differentiate from a quiescent state into proliferative and fibrotic myofibroblasts that express and secrete α-SMA and collagen types I (CoI-l), CoI-III, and CoI-IV, leading to liver fibrosis [ 7 ].…”

Section: Dietary Polyphenols Affect Hepatic Fibrosis Through Multiple...mentioning

confidence: 99%

Research Progress Regarding the Effect and Mechanism of Dietary Polyphenols in Liver Fibrosis

Chang,

Huang,

et al. 2023

Molecules

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The development of liver fibrosis is a result of chronic liver injuries may progress to liver cirrhosis and liver cancer. In recent years, liver fibrosis has become a major global problem, and the incidence rate and mortality are increasing year by year. However, there are currently no approved treatments. Research on anti-liver-fibrosis drugs is a top priority. Dietary polyphenols, such as plant secondary metabolites, have remarkable abilities to reduce lipid metabolism, insulin resistance and inflammation, and are attracting more and more attention as potential drugs for the treatment of liver diseases. Gradually, dietary polyphenols are becoming the focus for providing an improvement in the treatment of liver fibrosis. The impact of dietary polyphenols on the composition of intestinal microbiota and the subsequent production of intestinal microbial metabolites has been observed to indirectly modulate signaling pathways in the liver, thereby exerting regulatory effects on liver disease. In conclusion, there is evidence that dietary polyphenols can be therapeutically useful in preventing and treating liver fibrosis, and we highlight new perspectives and key questions for future drug development.

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Section: Dietary Polyphenols Affect Hepatic Fibrosis Through Multiple...mentioning

confidence: 99%

Research Progress Regarding the Effect and Mechanism of Dietary Polyphenols in Liver Fibrosis

Chang,

Huang,

et al. 2023

Molecules

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“…Malvidin Inducing HSCs apoptosis via the endoplasmic reticulum stress pathway and mitochondrial pathway [192] Pelargonidin Suppressing the ROS-NLRP3-IL-1 β axis via activating the Nrf2 pathway [193] Isoliquiritigenin Alleviates LF through caveolin-1-mediated hepatic stellate cells ferroptosis [194] Kaempferol Regulating miR-26b-5p/Jag1 axis and Notch pathway [195] Dihydroartemisinin [128,196,197] Hesperidin Inhibiting NF-κB/IL-1β/IL-10 and TGFβ/Smad2/3/CTGF signaling pathways [198] Carvacrol Inhibiting TRPM7 and modulating the MAPK signal [199] Small Ellagic Acid Regulates inflammatory mediators to inhibit TGF-β-mediated HSC activation [223] Sulforaphane Through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS/TLR4 signaling pathway [224] Tanshinone IIA Intervening TGFβ/ Smad signaling pathway [225] Protocatechuic acid [265] Byakangelicin [266] Quercetin [267] Gooseberry anthocyanins [268] Naringin (NIN) [268] Germacrone [269] Small-molecule natural products…”

Section: Small-molecule Natural Products Structural Formula Mechanism...mentioning

confidence: 99%

“…Apart from the above-mentioned natural products targeting HSC, natural products involved in the following related mechanisms: (1) Intervening in the TGFβ/Smad signaling pathway. The natural products involved are: Tanshinone IIA [225] , Protocatechuic acid [265] , Byakangelicin [266] , Quercetin [267] , Gooseberry anthocyanins [268] , Naringenin (NIN) [198] , Germacrone [269] , Brevilin A [270] , Curdione [271] , Limonin [272] , Piperlongumine [273] , Conophylline [274] , Apigenin [227] , Sal-B [219] , Taxifolin [275] , Vanillin [275] , Pterostilbene [276] , Sesamol [277] , Chelerythrine [278] , Physalin D [234] . (2) Reduced HSC activation by activating PPAR-g: Methoxyeugenol [226] , Apigenin [227] .…”

Section: Othersmentioning

confidence: 99%

Small-molecule natural products for reversing liver fibrosis based on modulation of HSCs activation: an update

Zheng

Yang

Luo

et al. 2022

Preprint

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Liver fibrosis (LF) is a trauma repair process carried out by the liver in response to various acute and chronic liver injuries, featured by excessive proliferation as well as abnormal dismissal of extracellular matrix as the main pathological features, and its continuous development will deteriorate into cirrhosis, liver cancer as well as other illnesses. The occurrence of LF is closely related to Hepatic stellate cells (HSCs) stimulation, and intervention in HSCs proliferation is expected to reverse LF. Plant-based small molecule drugs have anti-LF effects, and their mechanisms of action are related to anti-inflammation, anti-oxidative stress, as well as inhibition of abnormal accumulation of extracellular matrix. Consequently, new agents for HSCs will be required to furnish a possible curative response. Small-molecule natural products might be attractive for LF therapy. That is because they not only have the effect against HSCs, but also have excellent qualities such as low toxic side effects and easy availability from the perspective of safety and cost. In this review, we provide an updated review of the signal transduction pathways involved in HSCs and small-molecule natural products targeting HSCs reported in the past 3 years at home and abroad, with the aim of providing new ideas for the development of plant-based small molecule drugs targeting HSCs to reverse LF.

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“…It has certain curative effect on cardiovascular disease, diabetes and other chronic diseases. In the investigation, we found that gooseberry has good ability of anti-oxidation, antiin ammation and scavenging free radicals, preventing osteoporosis, lowering blood pressure and protecting radiation and cadmium [15][16][17]. Gooseberry fruit powder and fruit juice have signi cant effects on the prevention of alcoholic fatty liver and non-alcoholic fatty liver [18].Gooseberry showed good antioxidant and anti-in ammatory ability in the previous pre-experiment.…”

Section: Introductionmentioning

confidence: 99%

Gooseberry Anthocyanins Alleviates Insulin Resistance by Regulating Ceramide Metabolism in High Fat Diet Mice

Tang

Gao²,

Huang

et al. 2023

Preprint

Self Cite

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In order to explore the effect and mechanism of Gooseberry anthocyanins (GA) on reducing the ceramide content to reduce Insulin Resistance (IR) in mice.Molecular docking, Real-Time PCR and Western Blotting were used to explore the molecular mechanism and the effects of different doses GA in high-fat diet (HFD) mice.The results showed that the binding energy of anthocyanins on CerS6 was in the range of -8.2 to 5.2 kcal/mol, with low energy parameters and good binding positions. GA could effectively inhibit visceral fat, liver index, TC, TG and LDL-C, and improved HDL-C, GSH-Px and SOD.GA decreased the level of Insulin sensitivity index from-5.15 to-4.54 and improved insulin sensitivity and insulin resistance in HFD mice. Real-Time PCR and Western blotting results showed that GA could reducemRNA levels of inflammatory factors IL-6 and TNF-α, inhibit the expression of CerS6,PKCζ, PPARγ, CD36 and enhance the expression of SphK2, Akt, p-Akt/Akt, ISR. This study revealed the molecular mechanism of improving insulin resistance of GA in S1P/Cer signaling pathway, and provided theoretical support for preventive treatment of obesity related diseases by polyphenols.

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Gooseberry anthocyanins protect mice hepatic fibrosis by inhibiting TGF-β/Smad pathway

Cited by 9 publications

References 28 publications

Research Progress Regarding the Effect and Mechanism of Dietary Polyphenols in Liver Fibrosis

Research Progress Regarding the Effect and Mechanism of Dietary Polyphenols in Liver Fibrosis

Small-molecule natural products for reversing liver fibrosis based on modulation of HSCs activation: an update

Gooseberry Anthocyanins Alleviates Insulin Resistance by Regulating Ceramide Metabolism in High Fat Diet Mice

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