Gorham's disease of the maxilla: a case report

Perschbacher, Susanne E.; Perschbacher, Kristina; Pharoah, Michael J.; Bradley, G.; Lee, L; Yu, Eugene

doi:10.1259/dmfr/52099930

Cited by 14 publications

(16 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clinical features of Gorham's disease with maxillofacial involvement include pain, tooth mobility, pathological fracture, facial deformity and malocclusion. Radiologically, the condition is usually monocentric, and a large localised bone resorption without an associated soft tissue mass is seen. A common histological finding is vascular proliferation of thin‐walled, dilated vascular or lymphatic channels, which was not observed in our case.…”

Section: Discussionmentioning

confidence: 58%

“…Gorham's disease, also known as massive osteolysis and vanishing bone disease, is a rare condition that causes progressive and aggressive destruction of skeleton and replacement with fibrous tissue. The condition most commonly affects the shoulder and pelvis, but approximately 40 cases that involve maxillofacial region have been reported, with only three cases that involve maxilla alone.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of Gorham's disease is by exclusion of malignancy, infection and inflammatory conditions. Clinical features of Gorham's disease with maxillofacial involvement include pain, tooth mobility, pathological fracture, facial deformity and malocclusion.…”

Section: Discussionmentioning

confidence: 99%

“…Although the bone resorption is progressive, it may arrest spontaneously and rarely results in fatality. The aim of management is to arrest bone resorption and prevention of vital structure. Surgical resection with osseous graft often fails because of resorption of the graft.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Mysterious unilateral midfacial destruction – a diagnostic dilemma

Hong

Adcock

2016

Oral Surgery

View full text Add to dashboard Cite

We describe a case of progressive, significant, bony destruction of right midface over approximately 27 months from an unknown aetiology. A 58‐year‐old male patient originally presented with a white lesion in the upper right buccal sulcus, which a biopsy confirmed to be a benign hyperplastic inflammatory lesion. However, 16 months later, the patient returned with signs and symptoms suspicious of a malignant aetiology. A series of computed tomography scans over 27‐month period revealed progression of extensive permeative right midfacial bony destruction now with intracranial involvement. Contrary to the clinical and radiological findings, the histology results could not confirm malignancy and have been inconclusive on various occasions. We describe the clinical journey to date of this patient and discuss differential diagnoses: actinomycosis osteomyelitis; avascular necrosis of infective cause, such as mucormycosis; verrucous carcinoma; and Gorham's disease (massive osteolysis). We highlight the importance of a collaborative, multicentre, multidisciplinary approach to explore the results of investigations that conflict with the clinical picture of a complex case like this.

show abstract

Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Mysterious unilateral midfacial destruction – a diagnostic dilemma

Hong

Adcock

2016

Oral Surgery

View full text Add to dashboard Cite

show abstract

“…But the remineralisation or reformation of affected bones is not seen. Surgical resection of affected area with osseous graft placement has failed because of resorption of graft …”

Section: Discussionmentioning

confidence: 99%