Goserelin Versus Cyclophosphamide, Methotrexate, and Fluorouracil as Adjuvant Therapy in Premenopausal Patients With Node-Positive Breast Cancer: The Zoladex Early Breast Cancer Research Association Study

Jonat, W.; Kaufmann, M.; Sauerbrei, Willi; Blamey, R.W.; Cuzick, J.; Namer, M.; Fogelman, Ignac; Haes, Johannes; Matteis, A. De; Stewart, Alan L.; Eiermann, W.; Szakolczai, I; Palmer, Michael K; Schumacher, Martin; Geberth, M.; Lisboa, B. P.

doi:10.1200/jco.2002.05.042

Cited by 314 publications

(193 citation statements)

References 20 publications

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“…2a), the best cut-off points of dichotomized evaluation of ER and PR positivity were more than 10% positive nuclei (F score>1). Dichotomized ER and PR expression was also highly associated with favorable DFS and OS in the present study, which provides evidence to support the criteria commonly used in clinical practice and some clinical trials in the adjuvant setting (Ellis et al, 2001;Jonat et al, 2002;Thurlimann et al, 2005).…”

Section: Discussionsupporting

confidence: 69%

“…Using a definition of positivity as the presence of any level of staining by IHC, the Early Breast Cancer Trialists' Collaborative Group (EBCTCG, 2005) showed in a meta-analysis that tamoxifen significantly improved the prognosis of patients with ER positive tumors. However, in clinical practice and in some clinical trials, a cut-off of ≥10% ER and/or PR positive nuclei is often used for determining that a tumor is hormone receptor-positive and should be treated with adjuvant hormonal therapy (Ellis et al, 2001;Jonat et al, 2002;Thurlimann et al, 2005). The commonly applied 10% cut-off was established by Pertschuk et al (1996) who demonstrated a response to treatment in patients with metastatic breast cancer.…”

Section: Introductionmentioning

confidence: 99%

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Fractionated evaluation of immunohistochemical hormone receptor expression enhances prognostic prediction in breast cancer patients treated with tamoxifen as adjuvant therapy

Lin

Lien

et al. 2010

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To compare the prognostic prediction between dichotomized and fractionated evaluations of hormone receptor expressions. Methods: Patients with stages I-III breast cancers, who received adjuvant tamoxifen, were enrolled. The expression of estrogen receptor (ER) and progesterone receptor (PR) was evaluated by immunohistochemistry (IHC). A fractionated score (F score), the percentage of positive-staining nuclei (0=none, 1=1%-10%, 2=11%-30%, 3=31%-50%, 4=51%-70%, and 5=71%-100%), was assigned to each case. The dichotomized scoring method defines an F score >1 as positive. The prognostic values of both scores were compared by multiple Cox's proportional hazard models of disease-free survival (DFS) and overall survival (OS). Results: Four hundred and sixteen patients with a median follow-up of 78.0 months were included. F scores for ER and PR correlated directly with DFS and OS. Although both the dichotomized and fractionated ER and PR scores were significantly associated with DFS and OS in univariate analyses, only fractionated ER and PR scores remained as independent prognostic factors of DFS and OS in the final multiple Cox's proportional hazard models. Conclusion: Fractionated IHC hormone receptor expression evaluation enhances the prognostic prediction compared with a dichotomized assessment.

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Section: Discussionsupporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Fractionated evaluation of immunohistochemical hormone receptor expression enhances prognostic prediction in breast cancer patients treated with tamoxifen as adjuvant therapy

Lin

Lien

et al. 2010

J. Zhejiang Univ. Sci. B

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“…In a large study comparing Sonmezer,Oktay 425 www.TheOncologist.com the efficacy and tolerability of monthly goserelin treatment for 2 years (n = 817) with CMF (n = 823), goserelin produced a similar DFS to that seen with CMF in estrogen receptor-positive patients after a median follow-up of 6 years [55]. In contrast, goserelin was found to be inferior to CMF in estrogen receptor-negative patients.…”

Section: Use Of Nongonadotoxic Ovarian Suppression Regimens As Adjuvamentioning

confidence: 88%

Fertility Preservation in Young Women Undergoing Breast Cancer Therapy

2006

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“…RT was found to compare unfavorably with the use of goserelin, in which amenorrhea was noted in 95% of patients at 6 months, and only somewhat more favorably than the amenorrhea rate of 58.6% noted at 6 months with the use of polychemotherapy. 13 In that same study, amenorrhea persisted at 3 years in 22.6% and 76.9%, respectively, of patients treated with goserelin and CMF. These data imply that in cases in which the reliability and reversibility of ovarian ablation are important, luteinizing hormone-releasing analogs may be a more advantageous choice than RT.…”

Section: Discussionmentioning

confidence: 80%

Efficacy of radiotherapy for ovarian ablation

Hughes

Gray

Solin

et al. 2004

Cancer

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Both short‐ and long‐term cognitive changes continue to occur after coronary artery bypass grafting (CABG), but the pathophysiology of these neurobehavioral changes remains incompletely understood. The persistence of mild postoperative neurocognitive changes despite multiple improvements in the cardiopulmonary bypass procedure may be partially because of surgical populations being older and having more prevalent comorbid disease. The cause of the early postoperative changes is most likely multifactorial and may include ischemic injury from microemboli, hypoperfusion, and other factors resulting from major surgery. Several lines of evidence suggest that the late cognitive decline between 1 and 5 years after surgery may be secondary to high rates of cerebrovascular disease among candidates for CABG. A history of hypertension and other risk factors for vascular disease is known to be associated with increased risk for long‐term cognitive decline in community‐dwelling elderly individuals. Cerebrovascular risk factors are also associated with silent magnetic resonance imaging abnormalities in patients undergoing CABG. Thus, whereas both short‐ and long‐term postoperative cognitive changes have been associated with CABG, only the short‐term, transient changes appear to be directly related to the use of cardiopulmonary bypass.Ann Neurol 2005;57:615–621

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Goserelin Versus Cyclophosphamide, Methotrexate, and Fluorouracil as Adjuvant Therapy in Premenopausal Patients With Node-Positive Breast Cancer: The Zoladex Early Breast Cancer Research Association Study

Abstract: Goserelin offers an effective, well-tolerated alternative to CMF in premenopausal patients with ER-positive and node-positive early breast cancer.

Cited by 314 publications

References 20 publications

Fractionated evaluation of immunohistochemical hormone receptor expression enhances prognostic prediction in breast cancer patients treated with tamoxifen as adjuvant therapy

Fractionated evaluation of immunohistochemical hormone receptor expression enhances prognostic prediction in breast cancer patients treated with tamoxifen as adjuvant therapy

Fertility Preservation in Young Women Undergoing Breast Cancer Therapy

Efficacy of radiotherapy for ovarian ablation

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