Goserelin (Zoladex®) in the treatment of fibroids

West, Christopher C.; Lumsden, Mary Ann; Baird, D. T.

doi:10.1111/j.1471-0528.1992.tb13536.x

Cited by 22 publications

(4 citation statements)

References 20 publications

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“…Pretreatment of patients with GnRHa prior to hysterectomy has been advocated for patients with severe anaemia and in order to reduce blood loss during surgery. Other indications have included large fibroids or other factors that would make surgery technically difficult 11 . Pretreatment may also enable the greater use of vaginal rather than abdominal hysterectomy 12 or even more conservative surgical options such as laparoscopic hysterectomy.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of pre‐operative gonadotrophin hormone releasing analogues for women with uterine fibroids undergoing hysterectomy or myomectomy: a systematic review

Lethaby

Vollenhoven

Sowter³

2002

BJOG

189

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The use of GnRHa for three to four months prior to fibroid surgery reduces both uterine volume and fibroid size. They are beneficial in the correction of pre-operative iron deficiency anaemia, if present, and reduce intra-operative blood loss. If uterine size is such that a midline incision is planned, this can be avoided in many women with the use of GnRHa. For women undergoing hysterectomy, a vaginal procedure is more likely following the use of these agents.

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Section: Introductionmentioning

confidence: 99%

Efficacy of pre‐operative gonadotrophin hormone releasing analogues for women with uterine fibroids undergoing hysterectomy or myomectomy: a systematic review

Lethaby

Vollenhoven

Sowter³

2002

BJOG

189

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“…7,8 Medical therapy is an option for women with symptomatic myomas who prefer nonsurgical treatment, and consider fertility preservation, or expect a less aggressive operation after shrinkage of the uterine volume. 9,10 It has been well documented that fibroid growth and maintenance are stimulated by estrogen and are affected by cyclic hormonal changes. Estradiol and progesterone receptors have been identified in myomatous tissue and this fact may help in therapeutic hormonal manipulation of fibroids.…”

Section: Introductionmentioning

confidence: 99%

Medical Management of Uterine Leiomyoma: A Comprehensive Review

Kumari¹,

Devineni²

2015

Journal of South Asian Federation of Obstetrics and Gynaecology

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Uterine leiomyomas are most common benign tumors that occur in women of reproductive age. They are frequently associated with symptoms that impact on quality of life and require treatment. Treatment was usually surgical with either hysterectomy or myomectomy being performed. Although myomectomy conserves the uterus, it is associated with complications that might not enhance the chance of pregnancy and for those concerned about fertility, alternatives are being developed. Apart from therapeutic modalities like uterine artery embolization, other exciting developments are high intensity focused ultrasound and MRI guided focused ultrasound. New medical treatments are being evaluated—among which the progesterone receptor modulators that induce amenorrhea and a degree of fibroid shrinkage whilst having minimal effect on ovarian function are promising. This article gives a comprehensive overview of medical management of leiomyoma, reviews the literature and suggests further reading. How to cite this article Kumari SS, Devineni K. Medical Management of Uterine Leiomyoma: A Comprehensive Review. J South Asian Feder Obst Gynae 2015;7(2):71-76.

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“…The effects of gonadotrophin‐releasing hormone (GnRH) agonists on uterine and fibroid size have been well documented in the literature when used either as monotherapy 1–4 or as an adjunct to surgery 5,6 . The number of studies that compare treatment prior to surgery with surgery alone is quite small 7–11 . Although benefits have been observed in patients receiving only medical treatment 12 , it has been shown that fibroids treated in this way regrow following the cessation of medical treatment 13 .…”

Section: Introductionmentioning

confidence: 99%