Goshajinkigan for reducing chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis

Hoshino, Nobuaki; Ganeko, Riki; Hida, Koya; Sakai, Yoshiharu

doi:10.1007/s10147-017-1229-4

Cited by 22 publications

(27 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistently, in 2017, Kuriyama et al conduct a systematic review and meta-analysis, and further demonstrate that Goshajinkigan is impossible to prevent peripheral neuropathy in patients receiving neurotoxic chemotherapy. Next, Hoshino et al also conduct a systematic review and show that Goshajinkigan tends to prevent persistence but not severity of chemotherapy-induced peripheral neuropathy (Hoshino et al, 2018 ). Given the low quality and insufficient amount of the evidence, use of Goshajinkigan as standard of care is not currently recommended (Kuriyama and Endo, 2018 ).…”

Section: Need To Clarify the Prevention Of Neurotoxicitymentioning

confidence: 99%

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

et al. 2018

View full text Add to dashboard Cite

Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy are the common cancer treatments. However, the development of adverse effects resulting from chemotherapy and radiotherapy hinders the clinical use, and negatively reduces the quality of life in cancer patients. Natural products including crude extracts, bioactive components-enriched fractions and pure compounds prepared from herbs as well as herbal formulas have been proved to prevent and treat cancer. Of significant interest, some natural products can reduce chemotherapy and radiotherapy-induced oral mucositis, gastrointestinal toxicity, hepatotoxicity, nephrotoxicity, hematopoietic system injury, cardiotoxicity, and neurotoxicity. This review focuses in detail on the effectiveness of these natural products, and describes the possible mechanisms of the actions in reducing chemotherapy and radiotherapy-induced side effects. Recent advances in the efficacy of natural dietary supplements to counteract these side effects are highlighted. In addition, we draw particular attention to gut microbiotan in the context of prebiotic potential of natural products for the protection against cancer therapy-induced toxicities. We conclude that some natural products are potential therapeutic perspective for the prevention and treatment of chemotherapy and radiotherapy-induced side effects. Further studies are required to validate the efficacy of natural products in cancer patients, and elucidate potential underlying mechanisms.

show abstract

Section: Need To Clarify the Prevention Of Neurotoxicitymentioning

confidence: 99%

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

et al. 2018

View full text Add to dashboard Cite

show abstract

“…GJG significantly decreased glycated hemoglobin and progression of neuropathy (ankle reflex) when compared with the control. GJG is also used to prevent and relieve peripheral neuropathy due to chemotherapy (115).…”

Section: Neuropathic Painmentioning

confidence: 99%

Kampo Medicine for Various Aging-Related Symptoms: A Review of Geriatric Syndrome

et al. 2020

View full text Add to dashboard Cite

With the continued growth of the aging population in Japan, geriatric syndrome (GS), which is associated with aging-related symptoms, has become a social problem. GS is caused by physiological and pathological aging and may manifest various symptoms. Physicians use multidisciplinary approaches to provide treatment for individual GS symptoms. Kampo medicine, a Japanese traditional medicine that uses multiple pharmacologically active substances, is useful for many syndromes, conditions, disorders, and diseases associated with GS. Evidence of the effectiveness of Kampo medicine for GS has accumulated in recent years. The effects of Kampo treatment for symptoms related to functional decline of the cardiovascular, respiratory, and digestive systems, cognitive impairment and related disorders, pain and other sensory issues, among others, support the use of Kampo medicine for the management of GS. The role of Kampo medicine for GS is summarized in this review.

show abstract

“…Another 3 studies focused on oxaliplatin (evidence of low quality). In terms of the incidence of grade ≥2 OIPN, Tian et al 23 37,38 Incidence of Grade ≥3 CIPN/OIPN. A total of 7 studies summarized evidence on this outcome (evidence of low quality).…”

Section: Quality Of Evidence In the Included Systematic Reviews Assesmentioning

confidence: 99%

“…Two studies reported on safety outcomes with regard to incidence of adverse events and hematological toxicities. 29,37 One also reported on the rate of response to chemotherapy. Hoshino et al 37 , but there was no statistically significant difference in severe thrombocytopenia and severe kidney injury.…”

Section: Quality Of Evidence In the Included Systematic Reviews Assesmentioning

confidence: 99%

“…29,37 One also reported on the rate of response to chemotherapy. Hoshino et al 37 , but there was no statistically significant difference in severe thrombocytopenia and severe kidney injury. As well, no significant differences were observed on incidence of skin allergies between herbal hand and foot bath and control.…”

Section: Quality Of Evidence In the Included Systematic Reviews Assesmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Nonpharmacological Interventions in Chemotherapy-Induced Peripheral Neuropathy: An Overview of Systematic Reviews and Meta-Analyses

2020

View full text Add to dashboard Cite

Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) is one of the prevalent and disabling side effects of cancer treatment. However, management strategies for CIPN currently remain elusive, with treatment restricted to neuropathic pain medications, supportive care, and chemotherapy dosing adjustments. This overview explores evidence on the potential benefits and safety of nonpharmacological interventions in preventing and treating CIPN in cancer patients. Methods: Seven databases were searched for systematic reviews of randomized controlled trials (RCTs). The methodological quality of the selected reviews was assessed by AMSTAR 2, and the quality of evidence was judged by GRADE. Twenty-eight systematic reviews were considered eligible for this review. Results: It was found that nonpharmacological interventions (acupuncture, exercise, herbal medicine, nutritional supplements) provided potential benefits for patients with CIPN. Furthermore, Chinese herbal medicine, administered orally or externally, significantly prevented and/or relieved the incidence and severity of CIPN in comparison to control groups (no additional treatment, placebo, and conventional western medicine). However, the quality of evidence and strength of recommendations were compromised by the inconsistencies and imprecision of included studies. The main concerns regarding the quality of systematic reviews included the lack of sufficiently rigorous a priori protocols, and the lack of protocol registration adopted in the included studies. Conclusions: Though looking across reviews, Chinese herbal medicine appear generally effective in CIPN, uncertainty remains about the effects of many other nonpharmacological interventions. The evidence on what works was particularly compromised by reporting and methodological limitations, which requires further investigation to be more certain of their effects.

show abstract

Goshajinkigan for reducing chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis

Abstract: Goshajinkigan tended to prevent persistence but not severity of CIPN. Higher quality trials using multiple measures are needed in the future to clarify the preventive effect of Goshajinkigan and to assess the various aspects of CIPN.

Cited by 22 publications

References 23 publications

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

Kampo Medicine for Various Aging-Related Symptoms: A Review of Geriatric Syndrome

Effects of Nonpharmacological Interventions in Chemotherapy-Induced Peripheral Neuropathy: An Overview of Systematic Reviews and Meta-Analyses

Contact Info

Product

Resources

About