Gossypol inhibits proliferation of endometrioma cells in culture

Badawy, Shawky Z.A.; Souid, Abdul‐Kader; Cuenca, Violeta; Montalto, Nicholas; Shue, Frances

doi:10.1111/j.1745-7262.2007.00168.x

Cited by 11 publications

(4 citation statements)

References 18 publications

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“…Indeed, GP has been shown to inhibit cell growth in a dose-dependent manner in various species, including human. The majority of the studies evaluating the toxic effects of GP at the cellular level have been performed on cancer cells, including those of leukaemia [33], prostate cancer [34], breast cancer [35], ovarian cancer [36], carcinoma [37] and other malignancies [38], with the focus of preventing cancer metastasis. As a result, it has been reported that the proliferation of cancer cells is inhibited by GP toxicity.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Changes in Porcine Granulosa Cells in Response to Gossypol Cytotoxicity

Hong¹,

Choi²,

Kim³

et al. 2021

Preprint

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Background: Gossypol (GP) is a polyphenolic compound in cottonseed. In porcine, GP affects female reproduction and the respiratory system. The aim of this study was to identify differentially expressed genes in porcine granulosa cells (GCs) treated with GP (6.25 and 12.5 μM) for 72 h, in vitro . Results: In GP-treated groups (6.25 and 12.5 μM), the expressions of a number of genes were found to be significantly changed. Gene ontology analysis indicated that the identified DEGs were primarily related to the mitotic cell cycle, chromosome, centromeric region and protein binding. Kyoto Encyclopedia of Genes and Genomes pathway analysis of the GP6.25 group revealed that pathways related to the cell cycle, oocyte meiosis, progesterone-mediated oocyte maturation and p53 signaling were the most changed, while that of the GP12.5 group revealed that pathways related to the PI3K-Akt signaling, focal adhesion, HIF-1 signaling, cell cycle and ECM-receptor interaction were the most changed. Genes associated with female reproductive function ( CDK1 , CCNB1 , CPEB1 and MMP3 ), cellular component organization ( BIRC5 , CYP1A1 , TGFβ3 and COL1A2 ) and oxidation-reduction processes ( PRDX6 , MGST1 and SOD3 ) were confirmed to be differently expressed in GP-treated groups. Conclusion: Our findings provide insight regarding changes in GC gene expression in porcine exposed to GP.

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Section: Discussionmentioning

confidence: 99%

Transcriptome Changes in Porcine Granulosa Cells in Response to Gossypol Cytotoxicity

Hong¹,

Choi²,

Kim³

et al. 2021

Preprint

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“…The active groups of gossypol also contribute to its reactivity and biological activity. Gossypol -for the treatment of leukemia [1], lymphoma [2], colon carcinoma [3,4], breast cancer [5,6], myoma, prostate cancer [7] and other malignant tumors is a promising agent [8][9][10][11][12] and has broad-spectrum antiviral, antitumor, and antifungal activity.…”

Section: Introductionmentioning

confidence: 99%

Complexes of Water-Soluble Local Plant Polyphenol Derivatives and Their Biological Activity

Rezhepov,

Alimbayeva

2024

JCPRM

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The article is devoted to obtaining water-soluble complexes of iminoazo derivatives of gossypol, studying their physicochemical properties and biological activity. Aromatic, heterocyclic amines and sulfanilamide preparations were used as amine components in obtaining iminoazo derivatives of gossypol and their water-soluble complexes. The maximum values of wavelengths and the corresponding optical densities were determined in the UV spectra of compounds in acetone solvent. In order to determine the structure of the compounds, the infrared spectrum was taken and analyzed: the shift of the fundamental vibrational frequencies up to 31 cm-1 showed that the water-poly-N-vinylpyrrolidone in the compound is connected to a lesser extent as a result of hydrogen bonding. Obtaining complexes of azoderivatives of gossypol imines with poly-N-vinylpyrrolidone is related to the multi-functionality of the reactive groups of the ligand compound; formed hydrogen bonds due to the oxygen of the cycloamide group. For the first time, six new water-soluble complexes iminoazo derivatives of gossypol with poly-N-vinylpyrrolidone were obtained. The results of determination of interferon-inducing activity of compounds were analyzed. The activity was compared with the effectiveness of azo-, iminoazo derivatives of gossypol. According to the obtained results, it was shown that the effectiveness of water-soluble complexes iminoazo derivatives of gossypol.

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“…For agricultural application, gossypol ( Kong et al., 2010 ; Krempl et al., 2016 ) is used to control crop diseases and insect pests due to its good insect resistant characteristic and also for the control of rodent damage in the field due to its fertility resistance ( Hahn et al., 1981 ). In pharmaceutics, the antifertile trait of gossypol is made use of in the manufacturing of contraceptives ( Qian and Wang, 1984 ), drugs that inhibit the growth and proliferation of tumor cells ( Badawy et al., 2007 ; Ni et al., 2013 ), and it has obvious effect on the treatment of gynecological diseases ( Hsieh et al., 2020 ). However, the toxicity of gossypol limits its wide application as an important oil and feed raw material.…”

Section: Introductionmentioning

confidence: 99%

Detection and counting of pigment glands in cotton leaves using improved U-Net

She

Wang

et al. 2023

Front. Plant Sci.

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Gossypol, as an important oil and raw material for feed, is mainly produced by cotton pigment gland, and has a wide range of applications in the fields of pharmaceutics, agriculture and industry. Accurate knowledge of the distribution of pigment gland in cotton leaves is important for estimating gossypol content. However, pigment glands are extremely small and densely distributed, manual counting is laborious and time-consuming, and difficult to count quickly and accurately. It is thus necessary to design a fast and accurate gland counting method. In this paper, the machine vision imaging technology is used to establish an image acquisition platform to obtain cotton leaf images, and a network structure is proposed based on deep learning, named as Interpolation-pooling net, to segment the pigment glands in the cotton leaf images. The network adopts the structure of first interpolation and then pooling, which is more conducive to the extraction of pigment gland features. The accuracy of segmentation of the model in cotton leaf image set is 96.7%, and the mIoU (Mean Intersection over Union), Recall, Precision and F1-score is 0.8181, 0.8004, 0.8004 and 0.8004 respectively. In addition, the number of pigment glands in cotton leaves of three different densities was measured. Compared with manual measurements, the square of the correlation coefficient (R2) of the three density pigment glands reached 0.966, 0.942 and 0.91, respectively. The results show that the proposed semantic segmentation network based on deep learning has good performance in the detection and counting of cotton pigment glands, and has important value for evaluating the gossypol content of different cotton varieties. Compared with the traditional chemical reagent determination method, this method is safer and more economical.

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Gossypol inhibits proliferation of endometrioma cells in culture

Abstract: Gossypol invokes a potent toxicity on cultured endometrioma cells.

Cited by 11 publications

References 18 publications

Transcriptome Changes in Porcine Granulosa Cells in Response to Gossypol Cytotoxicity

Transcriptome Changes in Porcine Granulosa Cells in Response to Gossypol Cytotoxicity

Complexes of Water-Soluble Local Plant Polyphenol Derivatives and Their Biological Activity

Detection and counting of pigment glands in cotton leaves using improved U-Net

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