Gottron papules: a pathognomonic sign of dermatomyositis

Ricceri, Federica; Prignano, Francesca

doi:10.1503/cmaj.111791

Cited by 6 publications

(6 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with erythroderma show an erythematous and exfoliating diffuse rash, which is often pruritic. The diagnosis can be confirmed by performing a skin biopsy [ 3 , 4 ].…”

Section: Differential Diagnosismentioning

confidence: 99%

An unusual presentation of a case of human psittacosis

Weygaerde

Versteele

Thijs

et al. 2018

Respiratory Medicine Case Reports

View full text Add to dashboard Cite

BackgroundChlamydia psittaci is a gram-negative, obligate intracellular organism. Birds are the main reservoir, but also non-avian domestic animals and humans can be infected. In humans it mostly causes respiratory infections due to occupational exposure with varying severity. Sensitive and specific diagnostic tests are needed to define psittacosis in humans as these tests also allow rapid tracing of the animal source. However, diagnosis in humans is often based on time-consuming culture techniques and antibody detection assays as in many countries, the existing molecular diagnostic tests for psittacosis are not reimbursed by the public health insurance.Case presentationAn 82-year old female was referred to the hospital with a non-productive cough since four weeks and since one week fever up to 39 °C, myalgia, generalized skin rash, acral edema and generalized weakness under treatment with moxifloxacin. Blood analysis showed signs of inflammation with mild eosinophilia. Chest CT showed multiple peripheral ground glass opacities with consolidation in both lungs. Pulmonary function testing only showed a mild decrease in diffusion capacity. Viral and bacterial serology were negative. As the patient kept a pet parakeet for over ten years, a nested PCR for C. psittaci was performed on a nasopharyngeal swab of the patient and on feces of the parakeet. Both returned positive for the same genotype. Genotyping was performed by a genotype-specific real-time PCR. The patient fully recovered after a ten-day course of azithromycin.ConclusionDue to non-specific signs during psittacosis, early detection of the infection and differentiation from hypersensitivity pneumonitis can be challenging. Culture and antibody titers for C. psittaci have a lower sensitivity than PCR-testing due to several factors. We present a case of human psittacosis (presenting as pneumonia) with diagnosis based on clinical findings confirmed by means of nested PCR. This case suggests the added value of PCR in suspect cases despite negative serology. Our current paper underlines the need for a broader implementation of PCR for early diagnosis of human psittacosis and thus early initiation of correct antibiotic treatment with reduction of morbidity and mortality.

show abstract

“…Patients with erythroderma show an erythematous and exfoliating diffuse rash, which is often pruritic. The diagnosis can be confirmed by performing a skin biopsy [ 3 , 4 ].…”

Section: Differential Diagnosismentioning

confidence: 99%

An unusual presentation of a case of human psittacosis

Weygaerde

Versteele

Thijs

et al. 2018

Respiratory Medicine Case Reports

View full text Add to dashboard Cite

show abstract

“…Psoriasis is occasionally difficult to distinguish from eczema and atopic dermatitis [2]. Gottron's papule also resembles psoriasis [3,4]. Owing to its rarity in children, pediatricians have difficulties diagnosing psoriasis [5].…”

Section: Discussionmentioning

confidence: 99%

Juvenile psoriatic arthritis with rash on the hands and knees: diagnostic dilemma

et al. 2021

View full text Add to dashboard Cite

“…Dermatomyositis is an immunological disease, the pathogenesis resulting from various degrees of immunogenesis and the production of autoantibodies as suggested by evidence-based medicine. Autoantibodies commonly associated with dermatomyositis include: [10,12,13].…”

Section: Autoantibodies In Dermatomyositismentioning

confidence: 99%

“…Various forms of classification have been documented in the literature depending on the region and specialization of the authors. The six subtypes itemized below, however, describe the most common classification [2,3,13].…”

Section: Classificationmentioning

confidence: 99%

Dermatomyositis: A Case Report and Review of a Rare Autoimmune Inflammatory Disease

Okikiade

Afolayan-Oloye

Browne-Caesar³

et al. 2023

AIR

View full text Add to dashboard Cite

Dermatomyositis is a chronic progressive autoimmune disease of unknown etiology and rare occurrence worldwide. It is an immunologically mediated idiopathic inflammatory disease in which damage to small blood vessels contributes to injury and inflammation of muscle and skin. Dermatomyositis belongs to a heterogeneous group of three autoimmune rheumatological diseases termed idiopathic inflammatory non-suppurative myopathies, with polymyositis and inclusion body myositis as other component diseases. Dermatomyositis and polymyositis typically show characteristic clinical features of autoimmune inflammatory diseases and association with autoantibodies, HLA-DR genotype, and other autoimmune diseases. While it is known that inflammation plays a significant role in the pathogenesis of these diseases, its role in inclusion body myositis remains unclear. Overlapping forms of inflammatory myopathies that are poorly differentiated and defy a precise classification have also been identified. However, the clinical response to steroids and other immunosuppressive agents may help distinguish the subtypes of inflammatory myopathies from one another. Dermatomyositis is further described as a multisystemic rheumatologic disease presenting with muscular and cutaneous symptoms. It is associated with malignancy in 20 – 25% of patients. Dermatomyositis occurs in children and adults, with a higher incidence observed in women. Diagnosis is usually made from clinical manifestations, elevated blood enzymes, autoantibody testing, electromyography (EMG), and muscle biopsy. The diagnosis, however, remains challenging in third-world countries. There is no known cure for dermatomyositis. However, corticosteroids and other immunosuppressive agents, and intravenous immunoglobins are routinely used for treatment. The index patient in this review is a 22-year-old Afro-Caribbean woman whose presentation met the probable-to-definite criteria for diagnosis based on the Bohan and Peter Classification Criteria. This article is a case report and a detailed review of the autoimmune inflammatory disease known as dermatomyositis that can be used to teach about the disease condition.

show abstract

Gottron papules: a pathognomonic sign of dermatomyositis

Cited by 6 publications

References 3 publications

An unusual presentation of a case of human psittacosis

An unusual presentation of a case of human psittacosis

Juvenile psoriatic arthritis with rash on the hands and knees: diagnostic dilemma

Dermatomyositis: A Case Report and Review of a Rare Autoimmune Inflammatory Disease

Contact Info

Product

Resources

About