Gout and a Subsequent Increased Risk of Erectile Dysfunction in Men Aged 64 and Under: A Nationwide Cohort Study in Taiwan

Chen, Yung-Fu; Lin, Hung Hsin; Lu, Chao Tsang; Hung, Chin-Tung; Lee, Ming-Huei; Hsu, Chao‐Yu; Chung, Wei‐Sheng

doi:10.3899/jrheum.141105

Cited by 37 publications

(54 citation statements)

References 46 publications

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“…Of the remaining 8 articles, one was duplicate, one was editorial and one study only enrolled one patient with gout. Finally, a total of five studies [24–28] were deemed eligible for inclusion in this review.…”

Section: Resultsmentioning

confidence: 99%

“…Three published articles [24, 27, 28] and two conference publications [25, 26] were included in this work. The study design were either cross-sectional or cohort study.…”

Section: Resultsmentioning

confidence: 99%

“…Studies were categorized into low (scored 8–9), medium (scored 6–7), and high risk of bias groups (scored ≤5). Two cohort studies [27, 28] gained nine stars (Table 2). …”

Section: Resultsmentioning

confidence: 99%

“…Except for advanced age, other comorbidities were also recognized to be factors associated with the odds of getting ED. Chen et al reported that the incidence rate of ED for patients who had no gout but had 1 or more comorbidities was much higher than those who had gout but without comorbidities [28]. All the included studies reported lower adjusted OR than crude OR, suggesting that age and comorbidities could be risk factors of developing ED.…”

Section: Discussionmentioning

confidence: 99%

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Association between Gout and Erectile Dysfunction: A Systematic Review and Meta-Analysis

Liu

Song

et al. 2016

PLoS ONE

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BackgroundThe aim of this systematic review and meta-analysis was to assess the possible association between gout and erectile dysfunction (ED).MethodsStudies were identified by extensively searching EMBASE, Pubmed, CENTRAL and ISI Web of Science. Four electronic databases were searched from their inception date to the latest issue (March 2016), without language restriction. Each reviewer screened articles independently and was blinded to the findings of the other reviewer. Data was extracted in adherence to the predetermined data collection form and meta-analysis was conducted via RevMan 5.3.ResultsFive studies involving 56465 patients (mean age: 49.11 years) with gout and 155636 non-gout subjects (mean age: 48.76 years) were selected. The combination of unadjusted odds ratio (OR) showed that patients with gout were 1.44 times more likely to be diagnosed with ED when compared with control (95% confidence interval (95%CI) 1.20, 1.72). After adjustment for age and comorbidities, the heightened risk to develop ED was still present (1.18, 95%CI 1.02, 1.38). Subgroup-analysis by age showed statistically significant association of gout and ED in all age groups. However, evidence supporting a causal effect of gout on ED was insufficient.ConclusionThe findings of this review indicated a positive association of gout and ED, but this work is hampered by the heterogeneity among included studies, to some extent. Future studies with larger community-based homogeneous population and randomized controlled trials aimed to evaluate the effect of gout treatment on ED associated outcomes are needed at this point.

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Section: Resultsmentioning

confidence: 99%

“…Three published articles [24, 27, 28] and two conference publications [25, 26] were included in this work. The study design were either cross-sectional or cohort study.…”

Section: Resultsmentioning

confidence: 99%

“…Studies were categorized into low (scored 8–9), medium (scored 6–7), and high risk of bias groups (scored ≤5). Two cohort studies [27, 28] gained nine stars (Table 2). …”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association between Gout and Erectile Dysfunction: A Systematic Review and Meta-Analysis

Liu

Song

et al. 2016

PLoS ONE

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“…In the first of 2 related reports, the incidence of erectile dysfunction in Taiwan was compared in a nationwide cohort study among 19,368 men with gout compared to 77,472 age-matched controls 11 . Four controls without gout were identi fied for each man with gout.…”

mentioning

confidence: 99%

Gout and Association with Erectile Dysfunction

Gelber

2015

J Rheumatol

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Defining Depression and Anxiety in Individuals With Rheumatic Diseases Using Administrative Health Databases: A Systematic Review

Howren

Aviña‐Zubieta

Puyat

et al. 2020

Arthritis Care & Research

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Objective. To conduct a systematic review to describe how administrative health databases have been used to study depression and anxiety in patients with rheumatic diseases and to synthesize the case definitions that have been applied.Methods. Search strategies to identify articles evaluating depression and anxiety among individuals with rheumatic diseases were employed in Medline, Embase, CINAHL, Cochrane Database of Systematic Reviews, and Psy-cINFO. Studies included were those using administrative health data and reporting case definitions for depression and anxiety using International Classification of Diseases (ICD) codes. We extracted information on study design and objectives, administrative health database, specific data sources (e.g., inpatient, pharmacy records), ICD codes, operational definitions, and validity of case definitions.Results. Of the 36 studies included in this review, all studies assessed depression, and 13 studies (36.1%) evaluated anxiety. A number of specific ICD-9/10 codes were consistently applied to identify depression and anxiety, but the overall combination of ICD codes and operational definitions varied across studies. Twenty-four studies reported operational definitions, and 19 of these studies (79.2%) combined claims from more than 1 type of administrative data source (e.g., inpatient, outpatient). Validated case definitions were used by 6 studies (16.7%), with sensitivity estimates for depression and anxiety case definitions ranging from 33% to 74% and 42% to 76%, respectively.Conclusion. We identified numerous case definitions used to evaluate depression and anxiety among individuals with rheumatic diseases within administrative health databases. Recommendations include using case definitions with demonstrated validity as well as operationalizing case definitions within multiple data sources.

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Gout and a Subsequent Increased Risk of Erectile Dysfunction in Men Aged 64 and Under: A Nationwide Cohort Study in Taiwan

Abstract: This nationwide cohort study revealed that ED risk is significantly higher in patients with gout than in the general population.

Cited by 37 publications

References 46 publications

Association between Gout and Erectile Dysfunction: A Systematic Review and Meta-Analysis

Association between Gout and Erectile Dysfunction: A Systematic Review and Meta-Analysis

Gout and Association with Erectile Dysfunction

Defining Depression and Anxiety in Individuals With Rheumatic Diseases Using Administrative Health Databases: A Systematic Review

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