Gout: Clinical, Pathologic and Roentgenographs Observations

Rosenberg, Edward F.; Arens, Robert A.

doi:10.1148/49.2.169

Cited by 19 publications

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“…Structural joint damage is frequently observed in people with advanced gout 1. Both catabolic changes such as bone erosion and cartilage loss, and anabolic new bone formation (NBF) occur in affected joints 2–5.…”

Section: Introductionmentioning

confidence: 99%

Relationship between structural joint damage and urate deposition in gout: a plain radiography and dual-energy CT study

Dalbeth

Aati

Kalluru

et al. 2015

Annals of the Rheumatic Diseases

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Section: Introductionmentioning

confidence: 99%

Relationship between structural joint damage and urate deposition in gout: a plain radiography and dual-energy CT study

Dalbeth

Aati

Kalluru

et al. 2015

Annals of the Rheumatic Diseases

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“…This system may also assist in understanding the mechanisms and impact of joint damage in patients with gout. Although the relationship between tophaceous disease and bone erosion is well documented, the underlying cause of joint damage in gout remains speculative; a number of mechanisms have been suggested, including direct damage through proximity to the tophus, associated synovitis, and release of proinflammatory cytokines or matrix metalloproteases in response to uric acid crystals (25–28). Similarly, although radiographic damage has been well described as a prognostic factor in other forms of erosive arthritis, its relative importance in the prognosis of gout is uncertain.…”

Section: Discussionmentioning

confidence: 99%

Validation of a radiographic damage index in chronic gout

Dalbeth

Clark

McQueen

et al. 2007

Arthritis & Rheumatism

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Objective. To identify a valid method to measure radiographic damage in patients with chronic gout. Methods. The scoring method that best represented radiographic damage in individual joints was analyzed by comparing a gold standard rheumatologist consensus global score with recognized scoring methods, including the Sharp/van der Heijde erosion and narrowing scores, Ratingen destruction score, and Steinbrocker score. Ninety-five proximal interphalangeal joints from 12 patients with gout were included in this analysis. Scoring of hand and feet radiographs from an additional 35 patients with gout was used to analyze the sites to be included in a scoring system and the additional features to be recorded. Results. For individual joints, the combination of the Sharp/van der Heijde erosion and narrowing scores correlated best with the consensus global score. In addition, the limits of agreement were narrowest for the combined Sharp/van der Heijde erosion and narrowing score. All joint areas in the Sharp/van der Heijde rheumatoid arthritis score and the distal interphalangeal joints were affected by chronic gout and contributed to the total score. Additional features (extraarticular erosions, joint space widening, and ankylosis) occurred infrequently, and scoring of these features did not increase the reliability of the total score. The reliability of the total score was high: intraclass correlation coefficient for intraobserver reproducibility was 0.993-0.998 and for interobserver reproducibility was 0.963-0.966. The modified Sharp/van der Heijde score was able to discriminate between early and advanced disease. Conclusion. A modified Sharp/van der Heijde system accurately and reliably represents radiographic joint damage in chronic gout.

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Stoffwechsel- und Speicherkrankheiten

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Gout: Clinical, Pathologic and Roentgenographs Observations

Cited by 19 publications

References 0 publications

Relationship between structural joint damage and urate deposition in gout: a plain radiography and dual-energy CT study

Relationship between structural joint damage and urate deposition in gout: a plain radiography and dual-energy CT study

Validation of a radiographic damage index in chronic gout

Stoffwechsel- und Speicherkrankheiten

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