Gout, hyperuricemia and chronic kidney disease: New treatment possibilities

Kochman, Pawel; Stompór, Tomasz

doi:10.1016/j.poamed.2016.04.001

Cited by 6 publications

(7 citation statements)

References 37 publications

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“…Gout is a common arthritic disease associated with joint pain, fatigue, and high fever [ 1 ]. The prevalence of gout is estimated at 2%; it is especially observed among men over 40 years of age with concomitant metabolic syndrome [ 2 ]. The increasing trend of gout is likely to lead to increasingly large social costs, including direct costs related to medical treatment and indirect costs associated with absenteeism and presenteeism [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Gouty Arthritis and Antihyperuricemia Effects of Sunflower (Helianthus annuus) Head Extract in Gouty and Hyperuricemia Animal Models

Teng

Liu

et al. 2017

BioMed Research International

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This study was performed to investigate the therapeutic effects and possible mechanisms of sunflower (Helianthus annuus) head extract (SHE) on gout. First, the components of sunflower head powder and SHE were analyzed systematically. SHE, especially SHEB (extracted with 20% ethanol and 80% double-distilled water), strongly suppressed the swelling of the ankles in rats with acute gout induced by monosodium urate (MSU) crystals and reduced the levels of uric acid and xanthine oxidase (XO) in mice with hyperuricemia induced by oteracil potassium and yeast extract powder. Hematoxylin and eosin staining indicated that SHEB reduced inflammation cells and increased the joint space in the ankle compared with the control rats with MSU-induced gout. In the rats with acute gout, among 13 detected inflammatory cytokines, SHEB significantly enhanced the serum levels of interleukin-10 and the monocyte chemoattractant protein 1 . In the mice with hyperuricemia, SHEB reduced the levels of glutathione peroxidase, superoxide dismutase, malondialdehyde, and nitrogen monoxide in liver tissues. The potential therapeutic effects of SHE on gout are probably due to the production of anti-inflammatory cytokines and the suppression of XO activity via the modulation of oxidative stress status.

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Section: Introductionmentioning

confidence: 99%

Anti-Gouty Arthritis and Antihyperuricemia Effects of Sunflower (Helianthus annuus) Head Extract in Gouty and Hyperuricemia Animal Models

Teng

Liu

et al. 2017

BioMed Research International

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Section: Discussionmentioning

confidence: 73%

“…An average efficacy above 65% is a good value for clinicians in order to ensure the reduction in SUA level and thus the incidence of hyperuricemia associated damages and manifestations. The use of HD in combination with diet modification and UALT could best increase its efficacy to prevent hyperuricemia as reported for allopurinol and febuxostat [ 15 , 28 , 29 ]. Although our findings are important, they should be considered and interpreted in light of some limitations: (1) the small sample size which may be improved in a multicenter study; (2) the long-term outcome regarding the efficacy of hemodialysis on uric acid clearance which is lacking and may be enhanced by multiple measurements of SUA levels, given that SUA may vary with time, and a long term evaluation of the effects of hemodialysis parameters; (3) the lack of strong criteria assessing diet which is a great source of purine and thus has an impact on SUA levels.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of the efficacy of hemodialysis on uric acid clearance in a sub-Saharan African population at the end stage kidney disease

et al. 2020

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Background: Uricemia dramatically rises with the stage of chronic kidney disease (CKD) and correlates with its mortality. Hemodialysis (HD) being the most used treatment at the end stage in sub-Saharan Africa, we sought to evaluate its efficacy on the clearance of uric acid (UAc) when used alone and twice per week. Methods: A cross-sectional study of all consenting patients with CKD stage 5 recruited at random during HD sessions in a reference Centre in Cameroon from January to April 2017. We collected socio-demographic data, relevant clinical information, HD related variables, and measured serum uric acid (SUA) levels before and after the dialysis to assess the uric acid clearance. A clearance between 65 and 80% and above 80% was considered as low and good efficacy of HD respectively. Statistical analysis was performed using SPSS version 21.0. Factors associated with HD efficacy were assessed using Fisher's exact test and are presented with their odds ratios (OR) and 95% confidence levels. Results: One hundred four patients (53 females) were included. The mean age was 49.9 ± 13.3 years. Hypertension (25%) and chronic glomerulonephritis (16%) were the main suspected etiologies of CKD. The median time on renal replacement therapy by HD was 3 years [1; 6]. The prevalence of hyperuricemia was 81.9%. The means of SUA levels were 78.8 ± 13.8 mg/L and 26.4 ± 6.6 mg/L respectively before and after dialysis. Mean SUA clearance was 66% ± 10%. The efficacy of HD on UAc was moderate in 92 (63.9%) and good in 2 (1.4%) patients. Excess weight (OR 0.4 [0.2; 0.9]) and Kt/Vurea < 1.2 (OR 0.1 [0.04; 0.2]) significantly reduces the efficacy of HD. Conclusion: HD used alone for 2 sessions per week has a moderate efficacy on uric acid clearance in CKD. Therefore, we should improve the Kt/V (> 1.2), and combine HD to uric acid lowering drugs and diet modifications to increase its efficacy.

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“…Its incidence is associated with increased longevity, lifestyle changes, ( 4 ) diet, ( 7 ) and increased prevalence of metabolic syndrome. ( 8 , 9 )…”

Section: Introductionmentioning

confidence: 99%

Articular mobilization promotes improvement in functional and inflammatory parameters in a gouty arthritis model

Hoss,

Pradal,

Leal

et al. 2023

Einstein (São Paulo)

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Gout, hyperuricemia and chronic kidney disease: New treatment possibilities

Cited by 6 publications

References 37 publications

Anti-Gouty Arthritis and Antihyperuricemia Effects of Sunflower (Helianthus annuus) Head Extract in Gouty and Hyperuricemia Animal Models

Anti-Gouty Arthritis and Antihyperuricemia Effects of Sunflower (Helianthus annuus) Head Extract in Gouty and Hyperuricemia Animal Models

Assessment of the efficacy of hemodialysis on uric acid clearance in a sub-Saharan African population at the end stage kidney disease

Articular mobilization promotes improvement in functional and inflammatory parameters in a gouty arthritis model

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