A tuned liquid column damper (TLCD) is a more effective form of passive control for structural vibration suppression and may be promising for floating platform applications. To achieve good damping effects for a TLCD under actual working conditions, factors that influence the damping characteristics need to be identified. In this study, the relationships between head loss coefficients and other factors such as the total length of the liquid column, opening ratio, Reynolds number, Kc number, and horizontal length of the liquid column were experimentally investigated. By using a hydraulic vibration table, a vibration test system with largeamplitude motion simulation, low-frequency performance, and large stroke force (displacement) control is devised with a simple operation and at low cost. Based on the experimental method of uniform design, a series of experimental studies were conducted to determine the quantitative relationships between the head loss coefficient and other factors. In addition, regression analyses indicated the importance of each factor affecting the head loss coefficient. A rapid design strategy of TLCD head loss coefficient is proposed. This strategy can help people conveniently and efficiently adjust the head loss coefficient to a specified value to effectively suppress vibration.