The dominant approach to the study of international political economy assumes that the policy preferences of individuals and groups reflect economic self-interest. Recent research has called this assumption into question by suggesting that voters do not have economically self-interested preferences about trade policy. We investigate one potential explanation for this puzzling finding: economic ignorance. We show that most voters do not understand the economic consequences of protectionism. We then use experiments to study how voters would respond if they had more information about how trade barriers affect the distribution of income. We find that distributional cues generate two opposing effects: they make people more likely to express self-serving policy preferences, but they also make people more sensitive to the interests of others. In our study both reactions were evident, but selfish responses outweighed altruistic ones. Thus, if people knew more about the distributional effects of trade, the correlation between personal interests and policy preferences would tighten. By showing how the explanatory power of economic self-interest depends on beliefs about causality, this research provides a foundation for more realistic, behaviorally informed theories of international political economy.Over the past two decades, open-economy politics (OEP) has emerged as the dominant paradigm in the field of international political economy. Scholars working in this tradition reason "from the most micro-to the most macro-level." 1 They use economic theory to derive the policy preferences of individuals and groups within a country, and then investigate how political institutions and international bargaining translate preferences into actual policies. Initially developed to explain trade policy, OEP has been extended to many other issues, including international monetary policy, capital controls, foreign investment, foreign aid, and immigration. 2 Today OEP is recognized as the principal approach to international political economy in the United States, and it has transformed scholarship in other parts of the world as well. 3 We are grateful for helpful comments from many colleagues, including