GOx-Functionalized Platelet Membranes-Camouflaging Nanoreactors for Enhanced Multimodal Tumor Treatment

Du, Ying; Wang, Shujun; Luan, Jianfeng; Zhang, Meilin; Chen, Baoan; Shen, Yanfei

doi:10.2147/ijn.s358138

Cited by 6 publications

(4 citation statements)

References 35 publications

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“…Specifically, GOx‐functionalized PMs have been made to coat manganese dioxide which is a nanoshell assembling DOX‐loaded nanoparticles. This results in enhanced and more targeted tumor‐killing effects 194 . Li et al 195 .…”

Section: Platelets and Cancer Treatmentmentioning

confidence: 99%

“…This can effectively damage vessels and disrupt tumor angiogenesis 193 . PM has also been applied to novel cancer treatment, such as glucose oxidase (GOx)‐based starvation therapy 194 . Specifically, GOx‐functionalized PMs have been made to coat manganese dioxide which is a nanoshell assembling DOX‐loaded nanoparticles.…”

Section: Platelets and Cancer Treatmentmentioning

confidence: 99%

“…This results in enhanced and more targeted tumor-killing effects. 194 Li et al 195 discovered that compared with free DOX, DOX attached to nanodiamonds coated with PM showed a longer time staying in blood circulation and stronger inhibition of tumor growth. PM has been used to camouflage single-atom nanozyme.…”

Section: Application Of Nano-modified Platelet Carriers In Anticancer...mentioning

confidence: 99%

“… 193 PM has also been applied to novel cancer treatment, such as glucose oxidase (GOx)‐based starvation therapy. 194 Specifically, GOx‐functionalized PMs have been made to coat manganese dioxide which is a nanoshell assembling DOX‐loaded nanoparticles. This results in enhanced and more targeted tumor‐killing effects.…”

Section: Platelets and Cancer Treatmentmentioning

confidence: 99%

See 3 more Smart Citations

The role of platelets in the regulation of tumor growth and metastasis: the mechanisms and targeted therapy

Liao,

Zhang,

Liu

et al. 2023

MedComm

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Platelets are a class of pluripotent cells that, in addition to hemostasis and maintaining vascular endothelial integrity, are also involved in tumor growth and distant metastasis. The tumor microenvironment is a complex and comprehensive system composed of tumor cells and their surrounding immune and inflammatory cells, tumor‐related fibroblasts, nearby interstitial tissues, microvessels, and various cytokines and chemokines. As an important member of the tumor microenvironment, platelets can promote tumor invasion and metastasis through various mechanisms. Understanding the role of platelets in tumor metastasis is important for diagnosing the risk of metastasis and prolonging survival. In this study, we more fully elucidate the underlying mechanisms by which platelets promote tumor growth and metastasis by modulating processes, such as immune escape, angiogenesis, tumor cell homing, and tumor cell exudation, and further summarize the effects of platelet−tumor cell interactions in the tumor microenvironment and possible tumor treatment strategies based on platelet studies. Our summary will more comprehensively and clearly demonstrate the role of platelets in tumor metastasis, so as to help clinical judgment of the potential risk of metastasis in cancer patients, with a view to improving the prognosis of patients.

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Section: Platelets and Cancer Treatmentmentioning

confidence: 99%

Section: Platelets and Cancer Treatmentmentioning

confidence: 99%

Section: Application Of Nano-modified Platelet Carriers In Anticancer...mentioning

confidence: 99%

Section: Platelets and Cancer Treatmentmentioning

confidence: 99%

See 2 more Smart Citations

The role of platelets in the regulation of tumor growth and metastasis: the mechanisms and targeted therapy

Liao,

Zhang,

Liu

et al. 2023

MedComm

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Charting a Path to Tumor Therapy: Mastery of Luminescent Metal–Organic Frameworks for Precise Spatiotemporal Control

Gao,

Xu,

Wang

et al. 2024

Adv Funct Materials

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The field of drug delivery has significantly advanced tumor therapy, yet challenges such as the predictability of treatment outcomes and the real‐time monitoring of tumor progression, such as recurrence or metastasis. Luminescent metal–organic frameworks (L‐MOFs) are a promising solution to overcome these issues. This review offers a comprehensive exploration of the design and synthesis of L‐MOFs, presenting their crucial optical properties. The review highlights the pivotal role of L‐MOFs in enabling precision medicine for tumor treatment driven by their performance. Through strategically harnessing light‐manipulated metal–organic frameworks (MOFs), real‐time therapeutic monitoring and precise spatiotemporal control in tumor treatment can be achieved. Moreover, this review meticulously examines the influence of photomanipulating MOFs on in situ drug synthesis, introducing the catalytic role in light‐manipulated gas therapy. Additionally, the role of L‐MOFs as gene therapy vectors that utilize light to trigger gene expression responses is also comprehensively explored in the article, aiming to highlight their role in enabling tumor therapy through gene therapy. The review concludes by proposing an artificial intelligence (AI)‐mediated blueprint for tumor treatment with L‐MOFs, aiming to pave the way for innovative approaches through light manipulation.

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Cell membrane-based biomimetic technology for cancer phototherapy: Mechanisms, recent advances and perspectives

Li,

Meng,

Peng

et al. 2024

Acta Biomaterialia

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GOx-Functionalized Platelet Membranes-Camouflaging Nanoreactors for Enhanced Multimodal Tumor Treatment

Cited by 6 publications

References 35 publications

The role of platelets in the regulation of tumor growth and metastasis: the mechanisms and targeted therapy

The role of platelets in the regulation of tumor growth and metastasis: the mechanisms and targeted therapy

Charting a Path to Tumor Therapy: Mastery of Luminescent Metal–Organic Frameworks for Precise Spatiotemporal Control

Cell membrane-based biomimetic technology for cancer phototherapy: Mechanisms, recent advances and perspectives

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