2014
DOI: 10.1089/aid.2014.5309.abstract
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gp120/CD4 Blocking Antibodies Are Frequently Elicited in ART-naïve Chronically HIV-1 Infected Individuals

Abstract: Antibodies with the ability to block the interaction of HIV-1 envelope glycoprotein (Env) gp120 with CD4, including those overlapping the CD4 binding site (CD4bs antibodies), can protect from infection by HIV-1, and their elicitation may be an interesting goal for any vaccination strategy. To identify gp120/CD4 blocking antibodies in plasma samples from HIV-1 infected individuals we have developed a competitive flow cytometry-based functional assay. In a cohort of treatment-naïve chronically infected patients,… Show more

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