gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells

Nishikawa, Kimi; Millis, Albert J.T.

doi:10.1016/s0014-4827(03)00069-7

Cited by 188 publications

(160 citation statements)

References 42 publications

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“…All non-neoplastic adjacent liver tissues, primary HCC tissues, and metastatic lesions shown were obtained from the same patient ( Â 100 magnification). 1999) and VSMC (Nishikawa and Millis, 2003). In this study, expression profiling revealed a dramatic overexpression of YKL-40 in H2P-CLU cells.…”

Section: Discussionsupporting

confidence: 53%

Clusterin plays an important role in hepatocellular carcinoma metastasis

et al. 2005

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To identify genes associated with tumor metastasis in hepatocellular carcinoma (HCC), gene expression profiles between a pair of primary HCC (H2-P) and their matched metastatic HCC (H2-M) were compared. Overexpression of clusterin (CLU) was found in H2-M cells. To determine the roles CLU played in HCC metastasis, CLU was transfected into H2-P cells. Overexpression of CLU in H2-P cells increased cell migration by twofold in vitro and formation of metastatic tumor nodules in liver by eightfold in vivo. To evaluate the correlation of CLU expression with HCC metastasis, the expression levels of CLU in HCCs were investigated using a tissue microarray (TMA) containing 104 pairs of primary HCCs and their matched metastases. The frequency of CLU overexpression increased significantly in metastatic HCCs (59.1%) compared with that in primary tumors (32.6%, Po0.001). To gain additional insight into the function of CLU, the expression profile of H2P-CLU was compared with vector-transfected H2-P cells by cDNA microarray. A total of 35 upregulated and 14 downregulated genes were detected in H2P-CLU. One of the upregulated genes known as YKL-40, which is implicated in matrix-remodeling and metastasis, was further studied using TMA. A significant correlation (Po0.001) between the expression levels of YKL-40 and CLU was observed, implying that the CLU-YKL-40 pathway may play an important role in HCC metastasis.

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Section: Discussionsupporting

confidence: 53%

Clusterin plays an important role in hepatocellular carcinoma metastasis

et al. 2005

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“…Clinical studies revealed elevated YKL-40 levels particularly in diseases characterized with inflammation, extra-cellular remodeling and ongoing fibrosis (11). YKL-40 is also an adhesion and migration factor for vascular cells and is secreted by differentiated vascular smooth muscle cells (27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study

Kocaman¹,

Çetin²,

Durakoğlugil³

et al. 2013

Anadolu Kardiyol Derg

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Objective: YKL-40, a new biomarker of localized inflammation, is secreted by macrophages within the atherosclerotic plaques. Coronary artery ectasia (CAE) is a clinical entity with unclear etiopathogenesis. Some studies have revealed that CAE may be a form of atherosclerosis that has more localized and intense inflammatory properties than atherosclerosis. The goal of this study was to investigate YKL-40 and C-reactive protein (CRP) levels in patients with isolated CAE compared to patients with normal coronary arteries (NCA) and coronary artery disease (CAD). Methods: Our study has an observational and cross-sectional design. Forty-nine patients with isolated CAE (mean age: 60±10 years), 30 age-and gender-matched control participants with NCA (30 patients, mean age: 58±12 years) and 30 patients with CAD (mean age: 61±10 years), were included in the study. The relationship between YKL-40, CRP levels and the presence of CAE was investigated. Univariate and multiple logistic regression analysis were used for analysis of independent variables to predict CAE. Results: Serum YKL-40 levels were significantly different among study groups (NCA: 110±53 μg/L, CAE: 144±68 and CAD: 180±117, p=0.005). CAD group and CAE group had significantly higher YKL-40 levels than NCA group (p=0.004 and p=0.015, respectively). CRP was not significantly different between three groups. In addition, there were no any statistically significant differences, with respect to age, gender, the presence of hypertension or diabetes mellitus, and the smoking status (p>0.05). Logistic regression analysis revealed only YKL-40 level as the determinant of CAE (OR: 1.010, 95% CI: 1.001-1.019, p=0.027). Conclusion: YKL-40 levels in patients with isolated CAE compared to patients with NCA were found significantly high and only YKL-40 level was established as the determinant of CAE. We believe that further studies are needed to clarify the possible causative roles of YKL-40 in patients with isolated CAE. (

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“…YKL-40 may also have a role in angiogenesis, since it acts as a chemoattractant for umbilical vein endothelial cells, stimulates migration of these cells at a level comparable to that achieved by basic fibroblast growth factor, and modulates their morphology by promoting the formation of branching tubules [16]. It has also been demonstrated that YKL-40 is a novel adhesion and migration factor for vascular smooth muscle cells [17].…”

Section: Discussionmentioning

confidence: 99%

“…YKL-40 is a heparin and chitin-binding lectin [3,13] without chitinase activity [1,13]. The biological function of YKL-40 in cancer diseases is not known, but YKL-40 is a growth factor for connective tissue cells [14,15] and a potent migration factor for endothelial cells [16] and vascular smooth muscle cells [17].…”

Section: Introductionmentioning

confidence: 99%

High serum YKL-40 level in patients with small cell lung cancer is related to early death

et al. 2004

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Summary YKL-40, a growth factor for connective tissue cells, is secreted by cancer cells and macrophages. Elevated serum YKL-40 in patients with metastatic carcinoma has been associated with poor prognosis. We evaluated serum YKL-40 in 131 patients with small cell lung cancer (SCLC). Twenty-two percent of the patients with limited disease and 40% of the patients with extensive disease had elevated serum YKL-40. The median survival was 5.1 months for patients with elevated serum YKL-40 and 9.0 months for patients with normal serum YKL-40. Patients with elevated serum YKL-40 had increased hazard for death within the first 6 months after the start of chemotherapy compared to patients with normal serum YKL-40 (HR = 2.06, P = 0.009). Multivariate Cox analysis including routine prognostic variables showed that serum YKL-40 (P = 0.02) is independent of prognostic variables for survival within the first 6 months. Studies are needed to determine the function of YKL-40 in SCLC.

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gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells

Cited by 188 publications

References 42 publications

Clusterin plays an important role in hepatocellular carcinoma metastasis

Clusterin plays an important role in hepatocellular carcinoma metastasis

Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study

High serum YKL-40 level in patients with small cell lung cancer is related to early death

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