In the digital world, the demand for better interactions between subscribers and companies is growing, creating the need for personalized and individualized experiences. With the exponential growth of email usage over the years, broad flows of campaigns are sent and received by subscribers, which reveals itself to be a problem for both companies and subscribers. In this work, subscribers are segmented by their behaviors and profiles, such as (i) open rates, (ii) click-through rates, (iii) frequency, and (iv) period of interactions with the companies. Different regressions are used: (i) Random Forest Regressor, (ii) Multiple Linear Regression, (iii) K-Neighbors Regressor, and (iv) Support Vector Regressor. All these regressions’ results were aggregated into a final prediction achieved by an ensemble approach, which uses averaging and stacking methods. The use of Long Short-Term Memory is also considered in the presented case. The stacking model obtained the best performance, with an R2 score of 0.91 and a Mean Absolute Error of 0.204. This allows us to estimate the week’s days with a half-day error difference. This work presents promising results for subscriber segmentation based on profile information for predicting the best period for email marketing. In the future, subscribers can be segmented using the Recency, Frequency and Monetary value, the Lifetime Value, or Stream Clustering approaches that allow more personalized and tailored experiences for subscribers. The latter tracks segments over time without costly recalculations and handles continuous streams of new observations without the necessity to recompile the entire model.