GPHS‐RTG performance on the Galileo mission

Hemler, Richard J.; Cockfield, Robert D.

doi:10.1063/1.40170

Cited by 4 publications

(5 citation statements)

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“…VLA-2 was one of the first VLA proteins to be described. It was first identified on cytotoxic Tcell clones by the anti-VLA-p MoAb A-1A5, which recognized the 130 kD p'-subunit noncovalently linked to the 210 kDa'-and the 165 kD a'-chain (3). The identity of the VLA-2 molecule was confirmed by the MoAb 12FI.…”

Section: Discussionmentioning

confidence: 99%

“…Screening of tissues, cells and cell lines showed that 12F1 reacted with platelets, fibroblasts. the T-cell leukaemic line HSB, neuroblastoma cells and most adherent cell lines tested (3,7,8). VLA-2 has been identified as a collagen receptor (9,10) and corresponds to the glycoprotein-complex Ia-Ila on platelets (20).…”

Section: Discussionmentioning

confidence: 99%

“…It is one of five VLA molecules, with VLA-1, 3, 5 and 6, expressed on HUVE (13.14). VLA-2 has been identified as the major laminin receptor on HUVE although VLA-3 and VLA-6 (both laminin receptors) are also expressed on these cells (4).…”

Section: Discussionmentioning

confidence: 99%

“…They appear to be functionally distinct and have differing cell distributions (1). VLA-2, being one of the first VLA receptors to be identified, was so named because of its appearance 'very late' on mitogen-stimulatcd T cells and T cell clones (2,3). It was identified as a non-covalently linked heterodimer with a 165 kD a-chain and a 130 kD P-chain (4,5).…”

Section: Introductionmentioning

confidence: 99%

“…VLA-2, being one of the first VLA receptors to be identified, was so named because of its appearance 'very late' on mitogen-stimulatcd T cells and T cell clones (2,3). It was identified as a non-covalently linked heterodimer with a 165 kD a-chain and a 130 kD P-chain (4,5). With the production of a^ specific MoAb, such as 12F1 (5) and 5E8(6andM.…”

Section: Introductionmentioning

confidence: 99%

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VLA‐2 is a collagen receptor on endothelial cells

OʼConnell

Faull

Russ

et al. 1991

Immunology & Cell Biology

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Summary In order to identify cell-substrate adhesion receptors on vascular endothelium, murine monoclonal antibodies (MoAb) were raised against human umbilical vein endotheiial cells (HUVE). One anli-HUVE MoAb, RMACl 1. identified the adhesion receptor VLA-2 as it immunoprecipitated a non-covalently linked heterodimer of 160 kD and 130 kD. which was identical to the heterodimer immunoprecipitated by the anti-VLA-2 MoAb. 12F1 and 5E8. Furthermore, proteolytic peptide maps of the VLA-2 a-and [i-chains were highly homologous with those of the RMACl l-recognized molecule. However, unlike other VLA-2 MoAb. RMACl I also identified an 85 kD band which migrated to 90 kD under reducing conditions. This band was most likely a fragment of the 160 kD a-chain as a similar u-chain derived fragment has been demonstrated in the immunoprecipilates of some VLA-4 reactive monoclonals. However the possibility that this may be a novel molecule associated with VLA-2 has not been excluded. M viirn assays of HUVE adhesion to collagen types I and 4, lamininand fibronectin showed that RMACl I blocked adhesion to collagen (types 1 and 4) and laminin, but had no effect on HUVE adhesion to fibronectin. confirming that VLA-2 is a collagen and laminin reeeptor for HUVE.

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Section: Discussionmentioning

confidence: 99%