GPR107, a G-protein-coupled Receptor Essential for Intoxication by Pseudomonas aeruginosa Exotoxin A, Localizes to the Golgi and Is Cleaved by Furin

Tafesse, Fikadu G.; Guimarães, Carla P.; Maruyama, Takeshi; Carette, Jan E.; Lory, Stephen; Brummelkamp, Thijn R.; Ploegh, Hidde L.

doi:10.1074/jbc.m114.589275

Cited by 59 publications

(53 citation statements)

References 62 publications

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“…The only human protein containing this domain is GPR107. GPR107 localizes to the Golgi and is essential for intracellular vesicular transport (127) and proglucagon mRNA synthesis in pancreatic α-cells (128). The FNR domain within C3 from Neognathae can be traced back to proteins found already in ancient anaerobic bacteria and cyanobacteria.…”

Section: Early Coevolution Of Complement and Metabolismmentioning

confidence: 99%

Keeping It All Going—Complement Meets Metabolism

Kolev

Kemper²

2017

Front. Immunol.

380

553

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The complement system is an evolutionary old and crucial component of innate immunity, which is key to the detection and removal of invading pathogens. It was initially discovered as a liver-derived sentinel system circulating in serum, the lymph, and interstitial fluids that mediate the opsonization and lytic killing of bacteria, fungi, and viruses and the initiation of the general inflammatory responses. Although work performed specifically in the last five decades identified complement also as a critical instructor of adaptive immunity—indicating that complement’s function is likely broader than initially anticipated—the dominant opinion among researchers and clinicians was that the key complement functions were in principle defined. However, there is now a growing realization that complement activity goes well beyond “classic” immune functions and that this system is also required for normal (neuronal) development and activity and general cell and tissue integrity and homeostasis. Furthermore, the recent discovery that complement activation is not confined to the extracellular space but occurs within cells led to the surprising understanding that complement is involved in the regulation of basic processes of the cell, particularly those of metabolic nature—mostly via novel crosstalks between complement and intracellular sensor, and effector, pathways that had been overlooked because of their spatial separation. These paradigm shifts in the field led to a renaissance in complement research and provide new platforms to now better understand the molecular pathways underlying the wide-reaching effects of complement functions in immunity and beyond. In this review, we will cover the current knowledge about complement’s emerging relationship with the cellular metabolism machinery with a focus on the functional differences between serum-circulating versus intracellularly active complement during normal cell survival and induction of effector functions. We will also discuss how taking a closer look into the evolution of key complement components not only made the functional connection between complement and metabolism rather “predictable” but how it may also give clues for the discovery of additional roles for complement in basic cellular processes.

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Section: Early Coevolution Of Complement and Metabolismmentioning

confidence: 99%

Keeping It All Going—Complement Meets Metabolism

Kolev

Kemper²

2017

Front. Immunol.

380

553

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“…Similar to cholera toxin [38], the A domain of ETA is secreted from the lumen of the ER into the cytosol by Sec63, a complex that eliminates improperly folded proteins from the lumen of the ER [39], where direct interaction between ETA and Sec63 has been reported [40]. A genomewide genetic screen has recently identified host factors used by ETA to traffic into mammalian cells [41]. The A domain ADP-ribosylates EF-2, blocking messenger RNA (mRNA) translocation within the ribosome complex and inhibiting eukaryotic cell protein synthesis [42].…”

Section: Eta Intoxicates Mammalian Cellsmentioning

confidence: 98%

Pseudomonas aeruginosa toxins

Rolsma

Frank

Barbieri

2015

The Comprehensive Sourcebook of Bacterial Protein Toxins

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“…2-aminoacetophenone virulence factor [223] alkylquinoline signaling molecule [224] CFTR inhibitory factor virulence factor [225,226] elastase [227] ETA [228] ExoS virulence factor [228][229][230][231] ExoT virulence factor [228,229] Exotoxin A virulence factor [227,232] ExoU virulence factor [233][234][235][236][237] L-2-amino-4-methoxy-3-butenoic acid [238] lipopolysaccharide (LPS) endotoxin [239,240] Database on potential toxigenic capacities of microorganisms used for industrial production…”

Section: Pseudomonas Aeruginosamentioning

confidence: 99%

Database on the taxonomical characterisation and potential toxigenic capacities of microorganisms used for the industrial production of food enzymes and feed additives, which do not have a recommendation for Qualified Presumption of Safety

Benito

Ibáñez

Moncho

et al. 2017

EFSA Supporting Publications

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The present work constitutes the external scientific report of the EFSA open call OC/EFSA/FEED/2015/01. The aim of the call was to provide EFSA with a database from a review on the taxonomical description and potential toxigenic capacities of microorganisms used for the industrial production of feed additives and food enzymes. The review includes microorganisms used as source of feed additives and food enzymes for which EFSA has received or can potentially receive applications for safety assessment, and which have not been recommended for Qualified Presumption of Safety status. The database also comprises the molecular taxonomical identifiers and biosynthetic pathways involved in the production of toxic compounds and the responsible genes. The main result of the project is shown as a database developed according to the EFSA data structure. The methodological aspects and the queries used in the systematic search, as well as the procedure applied for the screening of scientific documents retrieved are described in this report. Details are available in supplementary appendices.In total, 22970 scientific documents were screened in the literature search, from which 411 were initially selected for providing pertinent data for the scope of the project. From the review of the selected articles, 474 bioactive secondary metabolites were recorded and 59 compounds were further studied in order to obtain data on their toxicology and the conditions in which they are produced by the microorganisms used in industrial fermentations. The database generated in this project comprises details that characterise, when available, the production conditions, genes involved and toxicity of these 59 compounds. This provides information that can be used to establish safety measures when using potentially toxigenic microorganisms in industrial fermentations Disclaimer: The present document has been produced and adopted by the bodies identified above as author(s). This task has been carried out exclusively by the author(s) in the context of a contract between the European Food Safety Authority and the author(s), awarded following a tender procedure. The present document is published complying with the transparency principle to which the Authority is subject. It may not be considered as an output adopted by the Authority. The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors. Acknowledgements:We thank the following EFSA satff: Jaime Aguilera, Margarita Aguilera-Gómez, Jane Richardson, Mario Monguidi and Davide Gibin for their valuable help and collaboration throughout the project. We also would like to thank the members of AINIA: Sonia Porta, Lidia Tomás, Joaquin Espí and Juan Antonio Nieto for providing expertise in biotechnology and molecular biology and contributing with their efforts to achieve the goals of this project, and Violeta Gómez from the University of Navarra for her colla...

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GPR107, a G-protein-coupled Receptor Essential for Intoxication by Pseudomonas aeruginosa Exotoxin A, Localizes to the Golgi and Is Cleaved by Furin

Cited by 59 publications

References 62 publications

Keeping It All Going—Complement Meets Metabolism

Keeping It All Going—Complement Meets Metabolism

Pseudomonas aeruginosa toxins

Database on the taxonomical characterisation and potential toxigenic capacities of microorganisms used for the industrial production of food enzymes and feed additives, which do not have a recommendation for Qualified Presumption of Safety

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