GPR56 and the Developing Cerebral Cortex: Cells, Matrix, and Neuronal Migration

Singer, Kathleen; Luo, Rong; Jeong, Sung‐Jin; Piao, Xiangshu

doi:10.1007/s12035-012-8343-0

Cited by 54 publications

(60 citation statements)

References 81 publications

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Section: Abstract: Neuron Gpcr Nerve Net Synapse Evolutionmentioning

confidence: 99%

“…Adhesion GPCRs are a growing research field, and several of these receptors have shown an important role in the CNS (Araç et al, 2012a; Langenhan et al, 2013;Strokes and Piao, 2010). For example, the brain-specific angiogenesis inhibitor (BAI) subfamily is involved in the control of synaptogenesis (Duman et al, 2013;Stephenson et al, 2014), whereas the latrophilins have been implicated in the control of synaptic transmission (O'Sullivan et al, 2012;O'Sullivan et al, 2014) and GPR56 is associated with brain development (Jeong et al, 2012;Luo et al, 2011;Singer et al, 2013).GPCRs are well represented in several primitive metazoans, as well as in some pre-metazoan species (de Mendoza et al, 2014; Krishnan et al, 2012;Nordström et al, 2011). Interestingly, several of the pre-bilaterian metazoans, which lack most of the cell types that are commonly found in the bilaterians, still constitute a rich repertoire of GPCRs (Patel, 2012;Technau and Steele, 2011).…”

mentioning

confidence: 99%

“…Moreover, knockout of CELSR2 and CELSR3 in mice leads to hydrocephalus (a lethal condition that accumulates excessive cerebrospinal fluid in the brain), suggesting that CELSR2 and CELSR3 are required for the development and function of ependymal cilia (Tissir et al, 2010). In addition, GPR56, which belongs to subfamily VIII is another adhesion GPCR that is involved in brain development (Singer et al, 2013). In humans, a mutation in GPR56 causes bilateral frontoparietal polymicrogyria (BFPP) syndrome, a condition where the cerebral cortex is malformed (Piao et al, 2004).…”

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confidence: 99%

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The role of G protein-coupled receptors in the early evolution of neurotransmission and the nervous system

Krishnan

Schiöth

2015

Journal of Experimental Biology

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The origin and evolution of the nervous system is one of the most intriguing and enigmatic events in biology. The recent sequencing of complete genomes from early metazoan organisms provides a new platform to study the origins of neuronal gene families. This review explores the early metazoan expansion of the largest integral transmembrane protein family, the G protein-coupled receptors (GPCRs), which serve as molecular targets for a large subset of neurotransmitters and neuropeptides in higher animals. GPCR repertories from four pre-bilaterian metazoan genomes were compared. This includes the cnidarian Nematostella vectensis and the ctenophore Mnemiopsis leidyi, which have primitive nervous systems (nerve nets), the demosponge Amphimedon queenslandica and the placozoan Trichoplax adhaerens, which lack nerve and muscle cells. Comparative genomics demonstrate that the rhodopsin and glutamate receptor families, known to be involved in neurotransmission in higher animals are also widely found in prebilaterian metazoans and possess substantial expansions of rhodopsin-family-like GPCRs. Furthermore, the emerging knowledge on the functions of adhesion GPCRs in the vertebrate nervous system provides a platform to examine possible analogous roles of their closest homologues in pre-bilaterians. Intriguingly, the presence of molecular components required for GPCR-mediated neurotransmission in pre-bilaterians reveals that they exist in both primitive nervous systems and nerve-cell-free environments, providing essential comparative models to better understand the origins of the nervous system and neurotransmission. KEY WORDS: Neuron, GPCR, Nerve net, Synapse, EvolutionIntroduction G protein-coupled receptors (GPCRs) constitute the largest superfamily among membrane bound proteins that control key physiological functions, such as, neurotransmission, hormone releases, and immune responses among others (Katritch et al., 2013; Lagerström and Schiöth, 2008;Rosenbaum et al., 2009). As such, the large range of integral transmembrane proteins in this family respond to subsequent, diverse array of ligands: including neurotransmitters, hormones, lipids, and odorants (Civelli et al., 2013;Shoichet and Kobilka, 2012). GPCRs in mammals are classified into the five main families according to the GRAFS classification: glutamate, rhodopsin, adhesion, frizzled and secretin (Fredriksson et al., 2003). These five GPCR families are associated with various physiological functions, but the roles of the glutamate and the rhodopsin families are particularly well documented for REVIEW Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, Box 593,751 24, Uppsala, Sweden.*Authors for correspondence (arunkumar.krishnan@neuro.uu.se; helgi.schioth@neuro.uu.se) neurotransmission and regulation of the nervous system (Niswender and Conn, 2010;Schoepp, 2001). Some functions include synaptic transmission, synapse formation, axon guidance and development of neuronal circuits (Collingridge et al., 2004;Hnasko and Edwards, 2012)...

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Section: Abstract: Neuron Gpcr Nerve Net Synapse Evolutionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The role of G protein-coupled receptors in the early evolution of neurotransmission and the nervous system

Krishnan

Schiöth

2015

Journal of Experimental Biology

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“…This subfamily is further characterized by an extremely long extracellular domain that contains a typical GPCR proteolytic site. GPR56 is expressed by meningeal fibroblasts, oligodendrocytes, melanoma cells, natural killer cells and cytotoxic T cells (Singer et al 2013;Yang et al 2014b). The GPR56 receptor binds to type III collagen but also to transglutaminase 2.…”

Section: Gpr56mentioning

confidence: 99%

Contribution of collagen adhesion receptors to tissue fibrosis

Coelho

McCulloch

2016

Cell Tissue Res

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Fibrosis is the result of a wound-healing response that fails to restore normal tissue structure function. One of the critical hallmarks of fibrosis is disrupted collagen remodeling. In tissue homeostasis, the production, deposition and organization of collagen is balanced by the degradation and remodeling of collagen within the existing matrix. After injury or chronic infection, tissues initiate a wound-healing response that is intended to create a new ECM for restoring tissue structure and function. If the wound-healing response is dysregulated or if the tissue injury or infection is severe or long-lasting, collagen deposition exceeds collagen degradation and the tissue repair process leads to fibrosis. The fibrotic repair response is extraordinarily complex and involves a wide spectrum of cells, signaling pathways and regulatory systems, some of which can be readily disrupted and thereby contribute to fibrotic lesions. The dysregulated collagen remodeling is a common end-point of all fibrotic disorders, and one of the rate-limiting steps of collagen remodeling is the binding of cells to collagen fibrils by specific cell adhesion receptors. In this review, we describe how the expression and function of collagen adhesion receptors contribute to collagen processing events that contribute to tissue fibrosis. Graphical abstract Balance between collagen remodeling in health and disease.

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“…93 It should also be mentioned here that tetraspanins associate with adhesion-Gprotein-coupled receptors (adhesion-GPCRs), a large family of GPCRs with extremely long extracellular N-terminals that contain a wide variety of domains, capable of interacting with many transmembrane and matrix-associated molecules. 94 Thus, taken together, tetraspanins may be important components in the architecture of contact-dependent intercellular signaling.…”

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confidence: 99%

Contact-dependent Signaling

Denef

2014

Cell Communication Insights

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ABSTRACT:It is becoming increasingly clear that communication between cells is carried out not only by the signaling molecules themselves, but also by many contextual and positional cues that arise from the way the signal is distributed and presented to the receptor. Many cells express transmembrane growth factors that use their extracellular domain for signaling to cells connected by adhesion. Some of these growth factors can also be receptors for a reverse signal from the adhesion partner. Secreted growth factors or their receptors can engage in contact-dependent signaling by associating with extracellular matrix (ECM) components and integrins. Signaling molecules can also reach cells at a distance via cytonemes that contact and activate the target cell through synapse-like structures.

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GPR56 and the Developing Cerebral Cortex: Cells, Matrix, and Neuronal Migration

Cited by 54 publications

References 81 publications

The role of G protein-coupled receptors in the early evolution of neurotransmission and the nervous system

The role of G protein-coupled receptors in the early evolution of neurotransmission and the nervous system

Contribution of collagen adhesion receptors to tissue fibrosis

Contact-dependent Signaling

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