One-way coupling often occurs in multi-dimensional stochastic models in finance. In this paper, we develop a highly efficient Monte Carlo (MC) method for pricing European options under a N -dimensional one-way coupled model, where N is arbitrary. The method is based on a combination of (i) the powerful dimension and variance reduction technique, referred to as drMC, developed in Dang et. al (2014), that exploits this structure, and (ii) the highly effective multilevel MC (mlMC) approach developed by Giles (2008). By first applying Step (i), the dimension of the problem is reduced from N to 1, and as a result, Step (ii) is essentially an application of mlMC on a 1-dimensional problem. Numerical results show that, through a careful construction of the ml-dr estimator, improved efficiency expected from the Milstein timestepping with first order strong convergence can be achieved. Moreover, our numerical results show that the proposed ml-drMC method is significantly more efficient than the mlMC methods currently available for multi-dimensional stochastic problems.