One of the goals of the American Academy of Sleep Medicine (AASM) is to provide clear, evidence-based recommendations in our clinical practice guidelines. Periodically, the AASM will assess and update the process by which these guidelines are developed so that it is in line with the standards currently being used for guideline development. The AASM is now taking the next step forward by fully adopting GRADE (Grading of Recommendation Assessment, Development and Evaluation) as the methodology used for evaluating evidence and forming clinical practice guidelines recommendations. Starting this year, AASM recommendations will be based on the following four interdependent domains: 1. quality of evidence; 2. balance of desirable and undesirable consequences; 3. patients' values and preferences; and 4. resource use (when known). AASM strengths of recommendations will be dichotomized into two categories: "Strong" and "Weak," either for or against a patient-care strategy. In an effort to provide clarity and transparency, all AASM recommendations will be actionable statements that include the specific patient population for which the patient-care strategy is recommended, and clearly define the comparator against which the patient-care strategy was evaluated. In some recommendations, the comparator will be an alternative patient-care strategy (e.g., a "gold standard" or previously available alternative), while in other recommendations the comparator will be a placebo or no treatment; this is determined by the availability of evidence, and analyses decisions made by the AASM task force. Implementation of the complete GRADE criteria by the AASM allows us the best path forward towards continuing to provide high quality clinical practice guidelines.
I NTRO DUCTI O NAmerican Academy of Sleep Medicine clinical practice guidelines (and the prior Practice Parameters and Best Practice Guides) are developed to bring the fruits of clinical and basic research into practice, offering guidance to practicing sleep specialists and other health care professionals who work with patients and families who suffer from sleep disorders. These guidelines have influenced clinical practice in the office and at the bedside, on a national and international level. It is therefore imperative that the very best efforts and techniques be applied to produce guidelines that are accurate, clear, and reliable. This document will describe some recent evolutionary changes to how recommendations will be developed by the AASM and how they will appear in AASM clinical practice guidelines, beginning this year.In 2009, the AASM began adopting GRADE (Grading of Recommendations Assessment, Development, and Evaluation) as the methodology for evaluating evidence and forming clinical practice guideline recommendations.1 The major impetus for this change was that, compared to the prior employed methodologies which heavily emphasized study design, GRADE placed weight on the systematic evaluation of a wider spectrum of characteristics of the evidence (e.g., not only study...