GRADE-Leitlinien: 1. Einführung – GRADE-Evidenzprofile und Summary-of-Findings-Tabellen

Langer, Gero; Meerpohl, Joerg J; Perleth, Matthias; Gartlehner, Gerald; Kaminski‐Hartenthaler, Angela; Schünemann, Holger J.

doi:10.1016/j.zefq.2012.05.017

Cited by 78 publications

(41 citation statements)

References 16 publications

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“…In addition, we carried out multiple subgroup analyses by different study characteristics. Finally, the overall quality of the evidence at each outcome level was assessed by the GRADE approach . Analyses were performed with Stata Version 12.0 (StataCorp LP, College Station, TX).…”

Section: Methodsmentioning

confidence: 99%

Cytomegalovirus Infection and Relative Risk of Cardiovascular Disease (Ischemic Heart Disease, Stroke, and Cardiovascular Death): A Meta‐Analysis of Prospective Studies Up to 2016

Wang

Geng

Bai

et al. 2017

JAHA

150

126

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BackgroundSeveral studies have suggested that cytomegalovirus infection is likely associated with an increased relative risk of cardiovascular disease (CVD); however, the results are inconsistent. We aimed to provide a systematic review and meta‐analysis of community‐based prospective studies assessing the association between cytomegalovirus infection and relative risk of CVD.Methods and ResultsWe searched Medline and EMBASE to retrieve prospective studies that reported risk estimates of the association between cytomegalovirus infection and relative risk of CVD. The search yielded 10 articles including a total of 34 564 participants and 4789 CVD patients. Overall, exposure to cytomegalovirus infection was associated with a 22% (relative risk: 1.22, 95% CI: 1.07–1.38, P=0.002) increased relative risk of future CVD. We estimated that 13.4% of CVD incidence could be attributable to cytomegalovirus infection.ConclusionsIn conclusion, cytomegalovirus infection is associated with a significantly increased relative risk of CVD.

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Section: Methodsmentioning

confidence: 99%

Cytomegalovirus Infection and Relative Risk of Cardiovascular Disease (Ischemic Heart Disease, Stroke, and Cardiovascular Death): A Meta‐Analysis of Prospective Studies Up to 2016

Wang

Geng

Bai

et al. 2017

JAHA

150

126

View full text Add to dashboard Cite

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“…As is known, RCTs are regarded as high-quality evidence unless they are limited by serious defects of bias due to the impact on study quality, inconsistency, indirectness, imprecise or sparse data, or high probability of reporting bias [29]. If any of the items mentioned above existed, the rating quality of evidence grade could be downgraded to moderate, low, or very low [30].…”

Section: Assessment Of Methodological Quality Of Included Studiesmentioning

confidence: 99%

“…The relative risk (RR) was calculated along with its 95 % confidence intervals (CIs) for binary outcomes and mean difference (MD) for continuous outcomes. Statistical heterogeneity between studies was assessed by means of chi-square, and the extent of inconsistency was assessed by the I 2 statistic [30]. If I 2 <50 %, we used the fixed-effects model, and the random-effects model was chosen with I 2 >50 %.…”

Section: Methodsmentioning

confidence: 99%

Hand-Sewn Versus Stapled Esophagogastric Anastomosis in the Neck: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Wang

Shi

et al. 2013

Indian J Surg

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The application of cervical esophagogastric anastomoses was of great concern. However, between circular stapler (CS) and hand-sewn (HS) methods with anastomosis in the neck, which one has better postoperative effects still puzzles surgeons. This study aims to systematically evaluate the effectiveness, security, practicality, and applicability of CS compared with the HS method for the esophagogastric anastomosis after esophageal resection. A systematic literature search, as well as other additional resources, was performed which was completed in January 2013. The relevant randomized controlled trials (RCTs) about the surgical technique for esophageal resection were included. Trial data was reviewed and extracted independently by two reviewers. The quality of the included studies was assessed by the recommended standards basing on Cochrane handbook 5.1.0, and the data was analyzed via RevMan 5 software (version 5.2.0). Nine studies with 870 patients were included. The results showed that in comparing HS to CS methods with cervical anastomosis, no significant differences were found in the risk of developing anastomotic leakages (relative risk (RR)=1.30, 95 % confidence intervals (CI) 0.87-1.92, p =0.20), as well as the anastomosis stricture (RR=0.97, 95 % CI 0.47-1.99, p =0.93), postoperative mortality (RR = 0.83, 95 % CI 0.43-1.58, p =0.57), blood loss (mean difference (MD)=39.68; 95 % CI −6.97, 86.33; p =0.10) and operative time (MD=18.05; 95 % CI −3.22, 39.33; p =0.10). However, the results also illustrated that the CS methods with cervical anastomosis might be less time-consuming and have shorter hospital stay and higher costs. Based upon this meta-analysis, there were no differences in the postoperative outcomes between HS and CS techniques. And the ideal technique of cervical esophagogastric anastomosis following esophagectomy remains under controversy.

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“…Eine Leitlinie soll evidenzbasierte Aussagen enthalten, um Ärzte und Patienten bei Entscheidungen über eine angemessene Versorgung in spezifischen klinischen Bedingungen zu unterstützen [13]. Um die Umsetzbarkeit von Empfehlungen möglich zu machen, sollen diese präzise formuliert sein [13].…”

Section: Einführungunclassified

Die DVO Osteoporose Leitlinie: eine Analyse der Evidenzlage zu Bisphosphonaten

2019

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ZusammenfassungIm Jahr 2017 veröffentlichte der Dachverband Osteologie (DVO) eine S3-Leitlinie zur Prophylaxe, Diagnose und Therapie der Osteoporose. Die Leitlinie war eine Aktualisierung der Version 2014 und basierte auf der Leitlinie der Scottish Intercollegiate Guidelines Network (SIGN) aus dem Jahr 2015. Die Update-Suche für 2014 bis 2016 wurde anhand der Methoden des AMWF (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften) durchgeführt.Wir haben die Evidenz der DVO-Leitlinie 2017 hinsichtlich der Empfehlungen für Bisphosphonat-Therapie überprüft. Insbesondere ging es uns darum, die Anzahl der Studien, ihre Größe und die Studiendauer zu ermitteln, weiters die definierten Endpunkte, um die Evidenzgrundlage der Empfehlungen für die klinische Praxis zu beurteilen. Wir untersuchten dies mit Hilfe des Leitfadens und des zugehörigen Methodenberichts sowie der Web-Appendices.Wir extrahierten die zitierten Studien der DVO-Leitlinie 2017 für Bisphosphonat-Therapie in eine MS Excel-Tabelle. Zusätzlich wurden Referenzen ergänzt, die in der SIGN-Leitlinie 2015 und im Rahmen der Update-Suche für die DVO-Leitlinie 2017 zitiert wurden. Neben den beiden Leitlinienberichten identifizierten wir im Web-Appendix „Anhang A“ Evidenztabellen für einige der zitierten Studien. Wir haben dann eine Studienart (randomisierte kontrollierte Studie oder systematische Übersichtsarbeit) zugeordnet und die Evidenzstufe für jedes Zitat notiert.Wir fanden insgesamt 72 Zitate bezüglich der Wirksamkeit der Biphosphonat-Therapie. Davon waren in der DVO-Leitlinie 49 Zitate enthalten, in der SIGN-Leitlinie 21 (davon 9 Duplikate) sowie 11 Zitate, die im Rahmen der Update-Suche zitiert wurden, jedoch in der Leitlinie 2017 selbst nicht enthalten waren. Weiters identifizierten wir 62 Artikel, die unerwünschte Ereignisse untersuchten. 56 wurden in der DVO-Leitlinie genannt, sieben in der SIGN-Leitlinie (davon zwei Duplikate) und ein Artikel in der Updatesuche. Da die ursprüngliche DVO-Richtlinie keine Evidenztabellen verwendet hat, standen lediglich Informationen über die Anzahl und Art der TeilnehmerInnen, die Art der Interventionen (einschließlich Dosis) und die Ergebnisse der Artikel der Update-Suche zur Verfügung. Es lagen keine Zusammenfassungen von Ergebnistabellen- oder GRADE-Evidenzprofile vor. Wir verwendeten den Ansatz der besten Evidenz und beschrieben die vorliegende Evidenz der Bisphosphonat-Therapie anhand der berichteten Evidenzgrade (SIGN oder Oxford-System) und der Evidenzhierarchie.

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GRADE-Leitlinien: 1. Einführung – GRADE-Evidenzprofile und Summary-of-Findings-Tabellen

Cited by 78 publications

References 16 publications

Cytomegalovirus Infection and Relative Risk of Cardiovascular Disease (Ischemic Heart Disease, Stroke, and Cardiovascular Death): A Meta‐Analysis of Prospective Studies Up to 2016

Cytomegalovirus Infection and Relative Risk of Cardiovascular Disease (Ischemic Heart Disease, Stroke, and Cardiovascular Death): A Meta‐Analysis of Prospective Studies Up to 2016

Hand-Sewn Versus Stapled Esophagogastric Anastomosis in the Neck: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Die DVO Osteoporose Leitlinie: eine Analyse der Evidenzlage zu Bisphosphonaten

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