Gradenigo's syndrome: A common infection with uncommon consequences

Vitale, Matthew P.; Misra, Amrit; Arora, Rajan; Lata, Julie

doi:10.1016/j.ajem.2017.07.020

Cited by 12 publications

(9 citation statements)

References 3 publications

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“…9). Petrous apicitis occurring in association with sixth nerve palsy, deep retroorbital/facial pain in the trigeminal distribution, and otomastoiditis is termed Gradinego syndrome [12,13]. Air cell opacity and bone erosion are best seen on CT (Fig.…”

Section: Mastoidmentioning

confidence: 99%

Cross Sectional Imaging of the Ear and Temporal Bone

Juliano

2018

Head and Neck Pathol

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CT and MR imaging are essential cross-sectional imaging modalities for assessment of temporal bone anatomy and pathology. The choice of CT versus MR depends on the structures and the disease processes that require assessment, delineation, and characterization. A thorough knowledge of the two imaging modalities' capabilities and of temporal bone anatomy greatly facilitates imaging interpretation of pathologic conditions.

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Section: Mastoidmentioning

confidence: 99%

Cross Sectional Imaging of the Ear and Temporal Bone

Juliano

2018

Head and Neck Pathol

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“…81 Alternatively (and very rarely), local spread of infection to the temporal bone apex may cause Gradenigo's syndrome. 82 This syndrome is associated with ipsilateral retro-orbital pain, abducens nerve palsy (unable to abduct the eyeball) and otorrhoea. Local infection can also spread into the inner ear, resulting in acute vertigo and, in some cases, sensorineural hearing loss.…”

Section: Treatment Of Otitis Media Complicationsmentioning

confidence: 99%

“…Rarely, a Bezold's abscess (due to infection tracking inferomedially in muscles of the neck) may result 81 . Alternatively (and very rarely), local spread of infection to the temporal bone apex may cause Gradenigo's syndrome 82 . This syndrome is associated with ipsilateral retro-orbital pain, abducens nerve palsy (unable to abduct the eyeball) and otorrhoea.…”

Section: Treatment Of Otitis Media Complicationsmentioning

confidence: 99%

Preventative and medical treatment of ear disease in remote or resource-constrained environments

et al. 2019

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BackgroundImportant ear problems can affect the outer ear, the middle ear and the inner ear. Globally, the greatest burden of disease is due to ear conditions that are associated with otorrhoea and hearing loss.MethodsThis study reviewed the literature on the prevention and treatment of common ear conditions that are most relevant to settings with high rates of ear disease and limited resources. The grading of recommendations assessment, development and evaluation (‘GRADE’) approach was utilised to assess interventions.ResultsAccurate diagnosis of ear disease is challenging. Much of the preventable burden of ear disease is associated with otitis media. Nine otitis media interventions for which there is moderate to high certainty of effect were identified. While most interventions only provide modest benefit, the impact of treatment is more substantial in children with acute otitis media with perforation and chronic suppurative otitis media.ConclusionDisease prevention through good hygiene practices, breastfeeding, reducing smoke exposure, immunisation and limiting noise exposure is recommended. Children with acute otitis media with perforation, chronic suppurative otitis media, complications of otitis media, and significant hearing loss should be prioritised for medical treatment.

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“…The condition primarily arises because of the extension of infection from the middle ear to the petrous apex of the temporal bone. The anatomical proximity of the petrous apex to crucial neurovascular structures contributes to the unique clinical features of Gradenigo's syndrome, making its early recognition and intervention imperative for optimal patient outcomes [1,2]. The syndrome's name pays homage to Giuseppe Gradenigo, an Italian otologist who first described this clinical entity in the early 20th century [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…The anatomical proximity of the petrous apex to crucial neurovascular structures contributes to the unique clinical features of Gradenigo's syndrome, making its early recognition and intervention imperative for optimal patient outcomes [1,2]. The syndrome's name pays homage to Giuseppe Gradenigo, an Italian otologist who first described this clinical entity in the early 20th century [1,2]. While Gradenigo's syndrome is a rare manifestation, understanding its pathophysiology and clinical presentation is crucial for healthcare providers, as delayed diagnosis and management may lead to severe complications, including intracranial involvement.…”

Section: Introductionmentioning

confidence: 99%

Gradenigo Syndrome: A Case Report of a Rare Complication of Otitis Media

Ali,

Alhantoosh,

Albaqal

et al. 2024

Cureus

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Otitis media, a common inflammation of the middle ear, frequently complicates upper respiratory infections. Gradenigo's syndrome, a rare complication, manifests as suppurative otitis media, abducens nerve palsy, and severe trigeminal nerve pain. Prompt recognition is vital because of the proximity of the infection to critical neurovascular structures. We present the case of a 38-year-old female who presented with facial pain, otalgia, and diplopia following an upper respiratory infection. Examination revealed facial weakness and abducens nerve palsy. Laboratory results showed elevated inflammatory markers. Imaging confirmed middle ear involvement. Antibiotics were initiated, and myringotomy was performed, resulting in a successful outcome. This case report contributes to understanding Gradenigo's syndrome's clinical nuances, emphasizing the necessity of a structured diagnostic and therapeutic approach. Ongoing research is crucial for refining diagnostic criteria, optimizing treatment, and enhancing pathophysiological understanding. Increased medical education is imperative to ensure early detection and improved patient outcomes.

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Gradenigo's syndrome: A common infection with uncommon consequences

Cited by 12 publications

References 3 publications

Cross Sectional Imaging of the Ear and Temporal Bone

Cross Sectional Imaging of the Ear and Temporal Bone

Preventative and medical treatment of ear disease in remote or resource-constrained environments

Gradenigo Syndrome: A Case Report of a Rare Complication of Otitis Media

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