Gradenigo Syndrome Caused by Nontuberculous Mycobacteria

Chen, Pey-Yu; Wu, Chen‐Chi; Yang, Tsung‐Lin; Hsu, Chuan‐Jen; Lin, Young-Tso; Lin, Kai‐Wei

doi:10.1159/000360413

Cited by 13 publications

(7 citation statements)

References 33 publications

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“…Petrous apicitis is an extension of infection from the mastoid air cells into a pneumatized petrous apex [4]. Most of the Gradenigo's syndrome cases are caused by pyogenic bacteria but nontuberculous mycobacteria (NTM) has also been implicated [5].However, no organism could be grown in this case. Majority of the patients are seen by ENT specialist as they have a history of otalgia or otorohea.…”

Section: Discussionmentioning

confidence: 94%

A Case of Abducens Nerve Palsy: Gradenigo's Syndrome

Thakur¹

2018

Intern Med

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A 51-year-old male presented with history of long standing on and off discharge from his left ear with increasing purulent discharge from the left ear since 30 days and double vision since last 7 days. He also had pain in left fronto-temporal area. Clinical examination revealed left abducens nerve palsy and perforation in left tympanic membrane. CT head showed left apical petrositis. He was diagnosed as a case of Gradenigo's syndrome.

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Section: Discussionmentioning

confidence: 94%

A Case of Abducens Nerve Palsy: Gradenigo's Syndrome

Thakur¹

2018

Intern Med

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“…Two patients had NTM temporal bone osteomyelitis, and had presented with otalgia, otorrhoea, facial palsy and granulation tissue and previous history of tympanic membrane perforation. Gardenigo syndrome caused by NTM has also been reported [ 24 ]. Our case fitted the definition of Gardenigo syndrome, diagnosed as temporal bone osteomyelitis caused by NTM.…”

Section: Discussionmentioning

confidence: 99%

Spectrum of mycobacterial pathogens responsible for head and neck tuberculosis-like presentation

Bala

Kumari

Monga

et al. 2021

Access Microbiology

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Tuberculosis (TB) of the head and neck can be contained in the lymph nodes, larynx, oropharynx, salivary glands, nose and paranasal sinuses, ear, skin and skull. Head and neck TB presentations are varied in nature and thus difficult to diagnose. The clinical features, radiological findings, microbiological diagnostic modalities, surgical and medical management and outcomes of nine cases of head and neck TB are discussed in detail here, together with a thorough review of the literature. Patients presented with atypical symptoms such as discharging sinus, ear lobule swelling, otitis media, vision loss and facial weakness, long refractory otorrhoea and granulation tissue in the ear canal. We diagnosed tubercular skull base osteomyelitis (one case) and laryngeal tuberculosis (two cases), mastoid tuberculosis (one case) and non-tubercular mycobacterial infection involving the temporal bone (two cases), sino-nasal region (one case), maxilla (one cases) and ear lobule (one case) over a period of 8 months. All patients were managed successfully with a combination of surgery and a well-planned treatment regimen for non-tuberculous mycobacteria (NTM) or anti-tubercular drugs for TB. All had successful outcomes except one patient with tubercular skull base osteomyelitis who expired before the initiation of anti-tubercular therapy (ATT). High clinical suspicion followed by thorough diagnostic work-up for both TB and NTM would enable early diagnosis and complete treatment.

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“…Clinically, it is characterized by the triad of suppurative otitis media, deep facial pain, and abducens palsy. Most of the Gradenigo syndrome cases that have been reported in the literature were caused by pyogenic bacteria [4] .…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

Gradenigo’s Syndrome a Rare Complication of Acute Otitis Media: Case Report and Literature Revue

Monia

Gdissa

Bellakhdher

et al. 2020

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

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Introduction: Gradenigo's syndrome is a rare complication of otitis media and mastoiditis involving the apex of the petrous temporal bone. This syndrome is characterized by a clinical triad of deep facial pain, sixth cranial nerve palsy, and acute otitis media (AOM). Case report: We report a case of a six-year-old girl, with no past medical history, who presented with a sudden diplopia following six days of headache and otorrhea. The diagnosis of gradenigo's syndrome was confirmed by clinical examination and imaging. She made a full recovery after 9 weeks of antibiotics. Discussion: Gradenigo's syndrome is a rare but life threatening complication of AOM. The inflammatory process starts in the middle ear, and spreads from the base to the top of the petrous portion of the temporal bone, producing several diagnostic symptoms. Careful clinical history and physical examination, including imaging, are necessary to make the diagnosis. Appropriate management requires antibiotic treatment and possible surgical intervention.

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Gradenigo Syndrome Caused by Nontuberculous Mycobacteria

Cited by 13 publications

References 33 publications

A Case of Abducens Nerve Palsy: Gradenigo's Syndrome

A Case of Abducens Nerve Palsy: Gradenigo's Syndrome

Spectrum of mycobacterial pathogens responsible for head and neck tuberculosis-like presentation

Gradenigo’s Syndrome a Rare Complication of Acute Otitis Media: Case Report and Literature Revue

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