Grading and prognosis of weight loss before and after treatment with optimal cutoff values in nasopharyngeal carcinoma

Ou, Qiaowen; Cui, Chunyan; Zeng, Xinchen; Dong, Annan; Wei, Xiaoyü; Chen, Mingyang; Liu, Lizhi; Zhao, Yongyi; Li, Haojiang; Lin, Weiqun

doi:10.1016/j.nut.2020.110943

Cited by 3 publications

(4 citation statements)

References 32 publications

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“…Previous studies have shown that weight loss due to radiotherapy has adverse effects on the prognosis of NPC patients. 30 , 31 Our study found that there was no significant difference in the degree of weight loss during radiotherapy between the two groups。Although there were significant differences in the severity of oral mucositis and oral pain between the two groups, the patient's swallowing function, and gastrointestinal digestion, and absorption function were less damaged by radiation in the two groups. What's more, thanks to the nutritional education during treatment, the patients were basically able to follow the doctor's advice to supplement nutrition.…”

Section: Discussionmentioning

confidence: 59%

Scheduling radiotherapy for patients with nasopharyngeal carcinoma in the corresponding time window can reduce radiation‐induced oral mucositis: A randomized, prospective study

Liao

et al. 2023

Cancer Medicine

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BackgroundTo explore a new method to reduce radiation‐induced oral mucositis by scheduling radiotherapy for patients with nasopharyngeal carcinoma (NPC) in the corresponding time window of the cycle of oral mucosal cells.MethodsEighty‐two NPC patients were randomly divided into a day group (n = 41) and a night group (n = 41). The radiotherapy was scheduled at noon (11:30–15:30) for the day group, while at night (19:00–23:00) for the night group. Oral mucositis and oral pain were recorded in both groups after each radiotherapy fraction. The short‐term efficacy of primary tumor regression, weight loss, and bone marrow suppression was recorded.ResultsThe incidence of Grade 2 oral mucositis was 87.8% (36/41) and 63.4% (26/41) in the night group and day group, respectively (p = 0.010). The incidence of Grade 3 oral mucositis was 65.9% (27/41) and 22.0% (9/41) in the night group and day group, respectively (p < 0.001). The mean number of radiotherapy for patients to develop Grade 2 oral mucositis was 15.67 ± 5.05 and 20.92 ± 6.21 in the night group and day group, respectively. The incidence of Grade 2 oral pain was 48.8% (20/41) and 22.0% (9/41) in the night group and day group, respectively (p = 0.011). There were no significant differences in tumor regression, weight loss, and bone marrow suppression between the two groups.ConclusionBy scheduling radiotherapy based on the corresponding time window of the cycle of oral mucosal cells, the severity of oral mucositis in NPC patients was reduced.

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Section: Discussionmentioning

confidence: 59%

Scheduling radiotherapy for patients with nasopharyngeal carcinoma in the corresponding time window can reduce radiation‐induced oral mucositis: A randomized, prospective study

Liao

et al. 2023

Cancer Medicine

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“…24,26 Additionally, our results confirm the recently published findings of a comprehensive study by Ou et al, who proposed the pretreatment percent weight loss as a vigorous prognostic marker after treatment in a group of 681 NPC patients. 27 The most remarkable finding of this current study was the successful demonstration of the significant prognostic influence of the pretreatment PAR values on the survival outcomes of LANPC patients treated with radical CCRT. Such that, a pretreatment PAR cutoff of 5.2 was able to stratify the study cohort into two gatherings with significantly different median and long-term PFS and OS results (Table 3).…”

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

High Pretreatment Platelet-to-Albumin Ratio Predicts Poor Survival Results in Locally Advanced Nasopharyngeal Cancers Treated with Chemoradiotherapy

Haksöyler¹,

Topkan²

2021

TCRM

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In a lack of similar research, we assessed the prognostic utility of pretreatment platelet-to-albumin ratio (PAR) in locally advanced nasopharyngeal carcinoma (LANPC) patients managed with concurrent chemoradiotherapy (CCRT). Patients and Methods: Present retrospective analysis included a sum of 128 consecutively treated LANPC patients who underwent cisplatinum-based radical CCRT. Availability of an ideal pretreatment PAR cutoff that may stratify the study population into two cohorts with significantly distinct survival outcomes was sought by utilizing the receiver operating characteristic (ROC) curve analysis. The primary and secondary endpoints were overall survival (OS) and progression-free survival (PFS), respectively. Results: A rounded 5.2 [area under the curve (AUC): 68.9%; sensitivity: 67.4%; and specificity: 65.2%] value was identified as the ideal PAR cutoff that grouped patients into two gatherings [PAR≥5.2 (N=60) versus <5.2 (N=68)]. The median follow-up duration was 86.4 months (range: 9-147). Kaplan-Meier comparisons between the two PAR groups revealed significantly diminished median PFS (69.4 versus 106.8 months for PAR<5.2; P< 0.012) and OS (88.3 versus not reached yet for PAR<5.2; P= 0.023) for the PAR ≥ 5.2 group. The results of multivariate analyses affirmed the pretreatment PAR≥5.2 as an independent prognostic factor that indicates diminished PFS (P= 0.016) and OS (P= 0.019) together with the respective N 2-3 nodal stage (versus N 0-1 ; P<0.05 for PFS and OS, respectively) and weight loss >5% at past six months (≤5%; P<0.05 for PFS and OS, respectively). Conclusion:The results of the current retrospective analysis provided a robust and independent adverse prognostic value for pretreatment PAR ≥ 5.2 in terms of median and longterm PFS and OS outcomes in LA-NPC patients this patient group treated with conclusive CCRT.

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“…However, these patients were found to have more positive outcomes, such as improved treatment response, greater overall survival, and increased progression-free survival. On the other hand, HNC patients with a normal and underweight pretreatment BMI were at greater risk of poor overall survival [20][21][22][23], prognosis [24,25], and extended hospital stays for underweight patients [26].…”

Section: Discussionmentioning

confidence: 99%

Predictive Factors for Critical Weight Loss in Saudi Head and Neck Cancer Patients Undergoing (Chemo)Radiotherapy

Redwan,

Kattan,

Alidrisi

et al. 2024

Cancers

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Weight loss is a significant health problem among patients with head and neck cancer (HNC) that is attributable primarily to the tumor or tumor therapy. Critical weight loss (CWL) is defined as the unintentional loss of ≥5% of weight. Therefore, this study’s goal was to investigate and determine the possible factors influencing CWL among patients with HNC who have received radiotherapy or concurrent chemoradiotherapy (CCRT). We conducted a retrospective analysis of 175 patients who received radiotherapy or CCRT as either their primary, adjuvant, or combined treatment at the Oncology Center in King Abdullah Medical City. All patients were ≥18 years of age and diagnosed with HNC with no metastasis. The study results showed that 107 patients (61%) had CWL, while 68 (39%) did not. The following factors were significantly predictive of CWL with a multivariate regression analysis: pretreatment BMI (AOR = 1.1, 95% CI = 1.02–1.17), oral cavity cancer (AOR = 10.36, 95% CI = 1.13–94.55), and male sex (AOR = 3.15, 95% CI = 1.39–7.11). In conclusion, weight loss is highly prevalent among HNC patients during treatment. Accordingly, pretreatment BMI, cancer in the oral cavity, and being male can be considered predictive factors for CWL.

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Grading and prognosis of weight loss before and after treatment with optimal cutoff values in nasopharyngeal carcinoma

Cited by 3 publications

References 32 publications

Scheduling radiotherapy for patients with nasopharyngeal carcinoma in the corresponding time window can reduce radiation‐induced oral mucositis: A randomized, prospective study

Scheduling radiotherapy for patients with nasopharyngeal carcinoma in the corresponding time window can reduce radiation‐induced oral mucositis: A randomized, prospective study

High Pretreatment Platelet-to-Albumin Ratio Predicts Poor Survival Results in Locally Advanced Nasopharyngeal Cancers Treated with Chemoradiotherapy

Predictive Factors for Critical Weight Loss in Saudi Head and Neck Cancer Patients Undergoing (Chemo)Radiotherapy

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