Gradual hydrophobization of silica aerogel for controlled drug release

Ganonyan, Nir; Bar, Galit; Gvishi, Raz; Avnir, David

doi:10.1039/d1ra00671a

Cited by 21 publications

(9 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although this relationship does not provide any direct mechanistic insights into the release process, first order kinetic models have been used to describe drug and nutrient release from controlled delivery systems. 80,81 Furthermore, it is well known that hydrophobic modifications can alter release of active ingredients from a matrix, 41,82,83 as these modifications alter solubility of bioactive compounds and delivery matrices in various media and other surface properties. [84][85][86][87] The rate Environmental Science: Nano Paper constants for phosphorus and potassium release for all of the control and gas phase (GP) modified CNF samples studied can be found in Table 2, along with adjusted correlation coefficients (R 2 ), calculated in Excel.…”

Section: Kinetic Analysis Of P and K Releasementioning

confidence: 99%

Modifying soluble NPK release with hydrophobized nanocellulose-based hydrogels for sustainable enhanced efficiency fertilizers

Gómez-Maldonado

Phillips

Vaidya

et al. 2024

Environ. Sci.: Nano

View full text Add to dashboard Cite

show abstract

Section: Kinetic Analysis Of P and K Releasementioning

confidence: 99%

Modifying soluble NPK release with hydrophobized nanocellulose-based hydrogels for sustainable enhanced efficiency fertilizers

Gómez-Maldonado

Phillips

Vaidya

et al. 2024

Environ. Sci.: Nano

View full text Add to dashboard Cite

show abstract

“…Further, alginate-based adsorbents are exploited for the removal of toxic metal ions from water . Typically, for the hydrophobic transition of aerogels, silanization, , pyrolysis − plasma treatment − are the commonly sought out routes. Alginate based aerogels offer a facile and inexpensive way of fabrication due to their ease of hydrogel formation with ionic cross-linkers.…”

Section: Applicationsmentioning

confidence: 99%

A Review on Hydrophobically Associated Alginates: Approaches and Applications

Akshaya,

Nathanael

2024

ACS Omega

View full text Add to dashboard Cite

Alginates are linear anionic polysaccharides, which are well-known for their biocompatible, nontoxic, and biodegradable nature. The polymer consists of alternating units of β-(1 → 4)-linked D-mannuronic acid (M) and α-(1 → 4)-linked L-guluronic acid (G) that have hydroxyl and carboxyl groups as the main functional groups. As a large number of free carboxyl and hydroxyl groups are present in the polymeric chain, the polymer is predominantly hydrophilic. The food and pharmaceutical industries have been the most extensive utilizers of alginates to produce gelling and thickening agents. However, by imparting hydrophobicity to alginates, the range of applications can be widened. Although there are reviews on alginate and its chemical modifications, reviews focusing on hydrophobically associated alginates have not been presented. The commonly used chemical modifications to incorporate hydrophobicity include esterification, Ugi reaction, reductive amination, and graft copolymerization. The hydrophobically modified alginates play an important role in delivery of hydrophobic drugs and pesticides as the modification increases the affinity toward hydrophobic components and helps in their sustained release. Due to their nontoxic and edible nature, they find use in the food industry as emulsion stabilizer to stabilize oil-in-water emulsions and to improve creaming ability. Further, alginate-based materials such as membranes, aerogels, and films are hydrophobically modified to improve their functionality and applicability to water treatment and food packaging. This Review aims to highlight the important chemical modifications and methods that are done to impart hydrophobicity to alginate, and the applications of hydrophobically modified alginates in different sectors ranging from drug delivery to food packaging are discussed.

show abstract

“…More recently, through a sol–gel technique and freeze-drying, sodium alginate–silica aerogels with good absorption rate were produced from rice husk waste [ 64 ]. Moreover, the manufacturing processes largely impact the characteristics and prices of these aerogels.…”

Section: Synthesis and Preparation Of Aerogelsmentioning

confidence: 99%

Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications

et al. 2023

View full text Add to dashboard Cite

At present, aerogel is one of the most interesting materials globally. The network of aerogel consists of pores with nanometer widths, which leads to a variety of functional properties and broad applications. Aerogel is categorized as inorganic, organic, carbon, and biopolymers, and can be modified by the addition of advanced materials and nanofillers. Herein, this review critically discusses the basic preparation of aerogel from the sol–gel reaction with derivation and modification of a standard method to produce various aerogels for diverse functionalities. In addition, the biocompatibility of various types of aerogels were elaborated. Then, biomedical applications of aerogel were focused on this review as a drug delivery carrier, wound healing agent, antioxidant, anti-toxicity, bone regenerative, cartilage tissue activities and in dental fields. The clinical status of aerogel in the biomedical sector is shown to be similarly far from adequate. Moreover, due to their remarkable properties, aerogels are found to be preferably used as tissue scaffolds and drug delivery systems. The advanced studies in areas including self-healing, additive manufacturing (AM) technology, toxicity, and fluorescent-based aerogel are crucially important and are further addressed.

show abstract

Gradual hydrophobization of silica aerogel for controlled drug release

Abstract: A gradual hydrophobization process of silica aerogel is presented, with minimal impact on porosity and transparency. Applicability is demonstrated in gradual tailoring the release rate of soluble and insoluble variants of a model drug, chlorhexidine.

Cited by 21 publications

References 51 publications

Modifying soluble NPK release with hydrophobized nanocellulose-based hydrogels for sustainable enhanced efficiency fertilizers

Modifying soluble NPK release with hydrophobized nanocellulose-based hydrogels for sustainable enhanced efficiency fertilizers

A Review on Hydrophobically Associated Alginates: Approaches and Applications

Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications

Contact Info

Product

Resources

About