Graft and diblock copolymer multifunctional micelles for cancer chemotherapy and imaging

Preparation and characterization of thermosensitive pluronic F127-b-poly(ɛ-caprolactone) mixed micelles

“…The use of mixed micelles obtained from a mixture of two or more block copolymers, with distinctly different properties can be a plausible candidate that is capable of tuning the resulting properties and meeting various requirements for specific application. To date, well studied examples for mixed micelles driven by non-covalent interactions include the mix of thermo-responsive/pH-responsive molecular [14], amphiphilic polymers/thermo-responsive polymers, amphiphilic polymers/pH-responsive molecules [15,16], amphiphilic polymers/diagnosis and targeting polymers [17][18][19][20], and so on. Through mixing the polymers with different functions, the mixed micelles have complementary effects in adjusting to external environmental changes, such as in temperature and diluted concentration, target-protein [21].…”

Terminal modification of polymeric micelles with π-conjugated moieties for efficient anticancer drug delivery

“…As most anticancer drugs are hydrophobic molecules with complex aromatic π-π conjugated structure, the π-π stacking interaction evoked between anticancer drugs and polymeric micelles would be favorable for drug loading. Recently, carbon nanomaterials of nanospheres [21], carbon nanotube [22], and graphene [23] were used to absorb anticancer drugs via π-π stacking interaction. Inspired by the M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 3 drug loading pattern in carbon nanomaterials, π-π stacking interaction between anticancer drug and carriers was introduced in polymeric nanoparticles.…”

Les nanoparticules polymères pour la délivrance de principes actifs anticancéreux

“…La fonctionnalisation des nanoparticules de PLA-b-PEG a notamment été décrite avec différents ligands de ciblage, tels que l'acide folique (vitamine B9), la biotine (vitamine B7), des peptides, des hydrates de carbone, des lectines 6 , de l'albumine, etc. En particulier, in vitro, la capture de nanoparticules fonctionnalisées avec l'acide folique par les cellules cancéreuses est supérieure à celle de nanoparticules dépourvues de la vitamine [20]. Des études réalisées in vivo ont également montré un ciblage actif de tumeurs cancéreuses et une inhibition efficace de la croissance tumorale.…”