Background/Aim. Monitoring the renal function following donor or radical
nephrectomy due to kidney tumors is considered to be essential. The aim of
this study was to compare pre-operative and post-operative renal function in
patients who underwent donor nephrectomy in relation to patients who
underwent radical nephrectomy due to renal malignancy. Methods. A
retrospective case-control study was performed, which included 199 patients
divided into two groups: Group 1 (105 patients) were patients who underwent
donor nephrectomy due to living related/unrelated kidney transplantation,
while group 2 (94 patients) was a control group and included patients who
underwent radical nephrectomy due to clear cell renal cell carcinoma in the
T1bNoM0 clinical stage, where this surgical procedure was the final form of
treatment. Results. Pre-operative eGFR EPI in the donor group was 94.95
ml/min/1.73m2, while in the radical nephrectomy patient group it was 71.00
ml/min/1.73m2. Patients who underwent radical nephrectomy tended to have GFR
below 60 ml/min/1.73m2 after ten years of follow-up compared with patients
who underwent donor nephrectomy. In the donor nephrectomy group, the average
GFR was 80.40 ml/min/1.73m2 and in the radical nephrectomy group it was
56.00 ml/min/1.73m2. A higher incidence of diabetes and hypertension was
also observed in the donor nephrectomy group of patients compared to the
radical nephrectomy group (HTA: 44.3% vs. 21.3%; diabetes: 22.6% vs. 9.6%,
respectively). Conclusion. Comparative monitoring of these two groups showed
that in both groups the recovery of renal reserve was achieved one year
after nephrectomy, due to the known adaptive mechanisms. Regardless of the
fact that with live transplantation in a kidney donor, we reduce the initial
renal reserve (nephrectomy, permanent loss of renal mass), due to the
adaptive mechanisms, kidney donors recover the kidney function within the
first year after surgery.