Graft copolymerization of glycerol 1,3-diglycerolate diacrylate onto poly(3-hydroxyoctanoate) to improve physical properties and biocompatibility

Kim, Hyung Woo; Chung, Moon Gyu; Kim, Young Baek; Rhee, Young Ha

doi:10.1016/j.ijbiomac.2008.07.002

Cited by 17 publications

(14 citation statements)

References 34 publications

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“…PHO was isolated and purified from lyophilized cells by hot chloroform extraction as described previously [4]. The purified PHO consisted of 4% 3-hydroxyhexanoate, 89% 3-hydroxyoctanoate, and 7% 3-hydroxydecanoate as determined by gas chromatography.…”

Section: Methodsmentioning

confidence: 99%

“…A large number of research groups have studied the interaction between biological species and materials with different wettabilities and have correlated the relationship between surface wettability and blood-or tissue-compatibility [10,14,15]. Cells adhere, spread, and grow more on surfaces with moderate hydrophilicity than on surfaces with higher or lower hydrophilicity [4]. Water contact angle measurements are widely used as a simple, sensitive technique to quantify the hydrophilic/hydrophobic properties of a surface [10].…”

Section: Characterization Of Vi-g-pho Copolymersmentioning

confidence: 99%

“…Actually, glycerol 1,3-diglycerolate diacrylate-grafted poly(3-hydroxyoctanoate) (GDD-g-PHO) has been prepared by heating homogeneous solutions of PHO with GDD. The resulting copolymers exhibit enhanced hydrophilicity and improved thermal and mechanical properties, as the GDD grafting density in the polymer chains increased [4].…”

Section: Introductionmentioning

confidence: 99%

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Biocompatibility and antimicrobial activity of poly(3-hydroxyoctanoate) grafted with vinylimidazole

Chung

Kim

et al. 2012

International Journal of Biological Macromolecules

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Section: Methodsmentioning

confidence: 99%

Section: Characterization Of Vi-g-pho Copolymersmentioning

confidence: 99%

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Biocompatibility and antimicrobial activity of poly(3-hydroxyoctanoate) grafted with vinylimidazole

Chung

Kim

et al. 2012

International Journal of Biological Macromolecules

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“…Chlorination can be done by either the addition to double bonds of the unsaturated PHA obtained from soybean oil (PHA-Sy) or substitution reactions with saturated hydrocarbon groups [67, 68]. Chlorination provides polyester with hard, brittle and crystalline physical properties depending on the chlorine content and also glass transition temperature has been shifted from − 40°C to +2°C [68]. For further functionalization, quaternization reactions of the chlorinated PHA with triethylamine (or triethanol amine) can be performed.…”

Section: Quaternization and Sulfonation Of The Phasmentioning

confidence: 99%

Pseudomonassp. as a Source of Medium Chain Length Polyhydroxyalkanoates for Controlled Drug Delivery: Perspective

Sujatha

Mahalakshmi

Sridhar

et al. 2012

International Journal of Microbiology

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Controlled drug delivery technology represents one of the most rapidly advancing areas of science. They offer numerous advantages compared to conventional dosage forms including improved efficacy, reduced toxicity, improved patient compliance and convenience. Over the past several decades, many delivery tools or methods were developed such as viral vector, liposome-based delivery system, polymer-based delivery system, and intelligent delivery system. Recently, nonviral vectors, especially those based on biodegradable polymers, have been widely investigated as vectors. Unlike the other polymers tested, polyhydroxyalkanoates (PHAs) have been intensively investigated as a family of biodegradable and biocompatible materials forin vivoapplications as implantable tissue engineering material as well as release vectors for various drugs. On the other hand, the direct use of these polyesters has been hampered by their hydrophobic character and some physical shortcomings, while its random copolymers fulfilled the expectation of biomedical researchers by exhibiting significant mechanical and thermal properties. This paper reviews the strategies adapted to make functional polymer to be utilized as delivery system.

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“…The results showed that cell attachment and proliferation were facilitated due to the presence of positively charged amino groups on their surfaces. Glycerol 1,3-diglycerol diacrylate-grafted poly(3-hydroxyoctanoate) (GDD-g-PHO) copolymers were prepared by Kim et al [28], and they reported that the GDD-g-PHO copolymers became more hydrophilic as the GDD grafting density in the copolymer increased, and biocompatibility was also enhanced by grafting of GDD groups.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of hydrophilic and spherical poly(glycerol dimethacrylate-co-glycerol-1,3-diglycerolate diacrylate) microbeads

Uğuzdoğan

2012

Designed Monomers and Polymers

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To cite this article: Erdal Uguzdogan (2013) Synthesis and characterization of hydrophilic and spherical poly(glycerol dimethacrylate-co-glycerol-1,3-diglycerolate diacrylate) microbeads, Designed Monomers and Polymers, 16:3, 250-262, DOI: 10.1080/15685551.2012 A new class of spherical and swellable microbeads was obtained by a newly proposed suspension polymerization protocol. Hydrophilic monomers in the form of crosslinking agent, glycerol dimethacrylate (GDMA), and glycerol 1,3-diglycerolate diacrylate (GDGDA) were copolymerized in an aqueous suspension medium. Poly(GDMA-co-GDGDA) microbeads were highly hydrophilic due to hydroxyl functionality from both crosslinking agents. In the proposed method, the organic phase including monomers and diluent (i.e. cyclohexanol) was dispersed in an aqueous medium by using poly(vinyl alcohol) as the stabilizer. Poly(GDMA-co-GDGDA) microbeads were obtained by changing GDMA/GDGDA ratio, monomer/diluent ratio, and stirring rate. The average size and size distribution properties, microbead yields, and the equilibrium swelling behavior of the gel beads were presented. Spherical and swellable bifunctional microbeads carrying hydroxyl-carboxyl or hydroxyl-amine groups were also obtained by including amine and carboxyl carrying functional monomers, 2-(dimethylamino)ethyl methacrylate, and methacrylic acid, respectively, in the suspension copolymerization proposed.

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Graft copolymerization of glycerol 1,3-diglycerolate diacrylate onto poly(3-hydroxyoctanoate) to improve physical properties and biocompatibility

Cited by 17 publications

References 34 publications

Biocompatibility and antimicrobial activity of poly(3-hydroxyoctanoate) grafted with vinylimidazole

Biocompatibility and antimicrobial activity of poly(3-hydroxyoctanoate) grafted with vinylimidazole

Pseudomonassp. as a Source of Medium Chain Length Polyhydroxyalkanoates for Controlled Drug Delivery: Perspective

Synthesis and characterization of hydrophilic and spherical poly(glycerol dimethacrylate-co-glycerol-1,3-diglycerolate diacrylate) microbeads

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