Graft function and incidence of cardiac allograft vasculopathy in donation after circulatory-determined death heart transplant recipients

Cheshire, Caitlin; Messer, Simon; Martinez, Luis; Vokshi, Ismail; Ali, Jason M.; Cernic, Sendi; Page, A.; Andal, Ryan; Berman, Marius; Kaul, Pratibha; Osman, Mohamed; Rafiq, Muhammad Umar; Goddard, Martin; Tweed, Katherine; Jenkins, David P.; Tsui, Steven; Large, Stephen; Kydd, Anna; Lewis, Clive J.; Parameshwar, Jayan; Pettit, Stephen; Bhagra, Sai

doi:10.1016/j.ajt.2023.07.003

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…Ex-situ machine perfusion, an alternative to NRP for DCD-heart retrieval, was discussed. It provides an alternative in countries where TA-NRP is currently prohibited, offering a successful mode of transplant in the medium term in both adults ( 31 ) and children ( 32 ). However, the use of available devices, such as the OCS system for donor hearts, is currently restricted to donors >50 kg and recipients >30 kg ( 33 ), and furthermore the licenced devices are expensive.…”

Section: Discussionmentioning

confidence: 99%

Normothermic regional perfusion in paediatric donation after circulatory determination of death—the Oxford position statement from ELPAT

Brierley,

Pérez-Blanco,

Stojanovic

et al. 2024

Front. Transplant.

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Section: Discussionmentioning

confidence: 99%

Normothermic regional perfusion in paediatric donation after circulatory determination of death—the Oxford position statement from ELPAT

Brierley,

Pérez-Blanco,

Stojanovic

et al. 2024

Front. Transplant.

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Cardiac allograft vasculopathy outcomes among donation after circulatory death heart transplant recipients

Birs,

Bui,

Gernhofer

et al. 2024

JHLT Open

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Outcomes of Heart Transplantation From Donation After Circulatory Death: An Up-to-date Systematic Meta-analysis

Zong,

Ye,

et al. 2024

Transplantation

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Background. Donation after circulatory death (DCD) heart transplantation (HTx) significantly expands the donor pool and reduces waitlist mortality. However, high-level evidence-based data on its safety and effectiveness are lacking. This meta-analysis aimed to compare the outcomes between DCD and donation after brain death (DBD) HTxs. Methods. Databases, including MEDLINE, Embase, CINAHL, and the Cochrane Central Register of Controlled Trials, were systematically searched for randomized controlled trials and observational studies reporting the outcomes of DCD and DBD HTxs published from 2014 onward. The data were pooled using random-effects models. Risk ratios (RRs) with 95% confidence intervals (CIs) were used as the summary measures for categorical outcomes and mean differences were used for continuous outcomes. Results. Twelve eligible studies were included in the meta-analysis. DCD HTx was associated with lower 1-y mortality rate (DCD 8.13% versus DBD 10.24%; RR = 0.75; 95% CI, 0.59-0.96; P = 0.02) and 5-y mortality rate (DCD 14.61% versus DBD 20.57%; RR = 0.72; 95% CI, 0.54-0.97; P = 0.03) compared with DBD HTx. Conclusions. Using the current DCD criteria, HTx emerges as a promising alternative to DBD transplantation. The safety and feasibility of DCD hearts deserve further exploration and investigation.

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Graft function and incidence of cardiac allograft vasculopathy in donation after circulatory-determined death heart transplant recipients

Cited by 3 publications

References 25 publications

Normothermic regional perfusion in paediatric donation after circulatory determination of death—the Oxford position statement from ELPAT

Normothermic regional perfusion in paediatric donation after circulatory determination of death—the Oxford position statement from ELPAT

Cardiac allograft vasculopathy outcomes among donation after circulatory death heart transplant recipients

Outcomes of Heart Transplantation From Donation After Circulatory Death: An Up-to-date Systematic Meta-analysis

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