Grafting a Safeguard against Cocaine Abuse

Mingxu,; Wu, Xiaoyang

doi:10.4303/jdar/236066

Cited by 1 publication

(2 citation statements)

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“…Now, in Molecular Psychiatry [ 15 ], we reported that one skin stem cell-based gene delivery platform for treating AUD and/or polysubstance abuse with cocaine. This work expands the application of the cutaneous gene delivery platform for treating cocaine abuse and overdose related deaths [ 16 – 18 ] to additional drug abuse and co-abuse.…”

Section: Introductionmentioning

confidence: 99%

“…This designed enzyme can also decompose cocaethylene. We found that hBChE-expressing skin grafts could effectively metabolize cocaine in circulation at a fast rate and decrease DA levels in the NAc in the brain as quantified by using microdialysis followed by liquid chromatography–mass spectrometry (LC–MS), and protect mice from development of cocaine-taking and cocaine-induced drug-seeking, as measured by the conditioned place preference behavioral method, as well as cocaine overdose-related deaths [ 16 , 17 ], thus potentially providing a long-term solution for safeguarding against key features of cocaine abuse [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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A Genetically Modified Skin Graft for Treating Alcohol Use Disorder and/or Polysubstance Abuse With Cocaine

Kong¹,

Wu²,

Xu³

2021

Adv. Drug Alcohol Res.

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Alcohol use disorder (AUD) is one of the foremost public health problems. Alcohol is also frequently co-abused with cocaine. There is a huge unmet need for the treatment of AUD and/or cocaine co-abuse. We have developed and used a skin stem cell-based gene delivery platform and found that production of the glucagon-like peptide-1 (GLP1) from the grafted genetically modified skin reduced development and reinstatement of alcohol-induced drug-taking and seeking, voluntary oral alcohol consumption and alcohol-induced increase in dopamine (DA) levels in the nucleus accumbens (NAc). Moreover, we have developed a novel co-grafting procedure for both modified human butyrylcholinesterase (hBChE)- and GLP1-expressing cells. Skin grafts-derived hBChE and GLP1 reduced acquisition of drug-taking and toxicity induced by concurrent alcohol and cocaine injections. These results imply that gene delivery through skin transplants may add a new option to treat drug abuse and co-abuse.

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Section: Introductionmentioning

confidence: 99%