2021
DOI: 10.3390/molecules26082358
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Grafting Dendrons onto Pillar[5]Arene Scaffolds

Abstract: With their ten peripheral substituents, pillar[5]arenes are attractive compact scaffolds for the construction of nanomaterials with a controlled number of functional groups distributed around the macrocyclic core. This review paper is focused on the functionalization of pillar[5]arene derivatives with small dendrons to generate dendrimer-like nanomaterials and bioactive compounds. Examples include non-viral gene vectors, bioactive glycoclusters, and liquid-crystalline materials.

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Cited by 4 publications
(2 citation statements)
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References 99 publications
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“…During the last two decades, molecular recognition via intermolecular weak interactions, involving hostguest inclusion complex formation with supramolecular macrocyclic compounds, such as cucurbit[n]urils, calix[n]arenes, cyclodextrins, cyclophanes, cyclopeptides, and pillar[n]arenes, has become an interesting new route to construct sophisticated and precisely modelled biological systems with multiple functions [1][2][3][4][5][6]. In particular, pillar [n]arenes which were rst reported in 2008 [7] have attracted considerable attention due to their signi cant importance in biomedical applications, biology, chemistry, physics, material science, nanotechnology, and environmental applications [8][9][10][11][12][13][14][15]. There exists evergrowing interest toward the usage of macrocyclic molecules as hosts to encapsulate drugs, which inherently provides more resistance to the drug degradation [16,17].…”
Section: Introductionmentioning
confidence: 99%
“…During the last two decades, molecular recognition via intermolecular weak interactions, involving hostguest inclusion complex formation with supramolecular macrocyclic compounds, such as cucurbit[n]urils, calix[n]arenes, cyclodextrins, cyclophanes, cyclopeptides, and pillar[n]arenes, has become an interesting new route to construct sophisticated and precisely modelled biological systems with multiple functions [1][2][3][4][5][6]. In particular, pillar [n]arenes which were rst reported in 2008 [7] have attracted considerable attention due to their signi cant importance in biomedical applications, biology, chemistry, physics, material science, nanotechnology, and environmental applications [8][9][10][11][12][13][14][15]. There exists evergrowing interest toward the usage of macrocyclic molecules as hosts to encapsulate drugs, which inherently provides more resistance to the drug degradation [16,17].…”
Section: Introductionmentioning
confidence: 99%
“…Different from meta-bridged calixarenes, the highly symmetrical scaffolds of pillararenes consist of para-linked hydroquinone units [56]. In particular, per-functionalized pillar [5]arenes (P [5]) with ten identical substituents on both rims are especially easy to be synthesized and functionalized, allowing for the construction of a wide range of supramolecular architectures [57][58][59][60]. Intensive investigations on the lectin binding properties of deca-glycosylated P [5]s, as well as glyco [2]rotaxanes featuring per-glycosylated P[5] ring components, have been reported.…”
mentioning
confidence: 99%