Grafting of [64Cu]-TPPF20 porphyrin complex on Functionalized nano-porous MCM-41 silica as a potential cancer imaging agent

Fazaeli, Yousef; Feizi, Shahzad; Jalilian, Amir Reza; Hejrani, Ali

doi:10.1016/j.apradiso.2016.03.003

Cited by 34 publications

(14 citation statements)

References 39 publications

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“…These nanoparticles showed high contrast and tumour uptake in xenograft models with fewer tendencies to accumulate in the macrophage system. Mesoporous silica nanoparticles (MSNs) are a type of silica particles with significant porous structure and can be labelled with both chelator‐free and chelator‐based reactions with several radiochemicals like 89 Zr, 96 18 F, 97,98 and 165 Ho, 99m Tc, and 64 Cu 99–101 . 89 Zr particularly shows strong affinity for binding to MSNs and dense silica (dSiO 2 ).…”

Section: Different Nanoparticle Systems Used For Delivery Of Radiophamentioning

confidence: 99%

Nanoparticulate formulations of radiopharmaceuticals: Strategy to improve targeting and biodistribution properties

Datta

Ray

2020

Labelled Comp Radiopharmac

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Application of nanotechnology principles in drug delivery has created opportunities for treatment of several diseases. Nanotechnology offers the advantage of overcoming the adverse biopharmaceutics or pharmacokinetic properties of drug molecules, to be determined by the transport properties of the particles themselves. Through the manipulation of size, shape, charge, and type of nanoparticle delivery system, variety of distribution profiles may be obtained. However, there still exists greater need to derive and standardize definitive structure property relationships for the distribution profiles of the delivery system. When applied to radiopharmaceuticals, the delivery systems assume greater significance. For the safety and efficacy of both diagnostics and therapeutic radiopharmaceuticals, selective localization in target tissue is even more important. At the same time, the synthesis and fabrication reactions of radiolabelled nanoparticles need to be completed in much shorter time. Moreover, the extensive understanding of the several interesting optical and magnetic properties of materials in nanoscale provides for achieving multiple objectives in nuclear medicine. This review discusses the various nanoparticle systems, which are applied for radionuclides and analyses the important bottlenecks that are required to be overcome for their more widespread clinical adaptation.

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Section: Different Nanoparticle Systems Used For Delivery Of Radiophamentioning

confidence: 99%

Nanoparticulate formulations of radiopharmaceuticals: Strategy to improve targeting and biodistribution properties

Datta

Ray

2020

Labelled Comp Radiopharmac

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“…The most commonly used radionuclide in SPECT/MRI is 99m Tc because of its excellent physical properties and extended availability through 99 Mo/ 99m Tc generators. It has been shown by many scientific groups that in vivo administration of 99m Tc-radiolabeled NPs can provide accurate biodistribution profiles and visualization of excretion route of radioactivity in vivo for a period of up to 24 h. In recent years, an increased interest for 99m Tc conjugated Fe 3 O 4 NPs has prompted researchers to design radiopharmaceuticals in SPECT/MRI dual-modality tumor imaging.…”

Section: D Nanocarriersmentioning

confidence: 99%

An overview of nanoscale radionuclides and radiolabeled nanomaterials commonly used for nuclear molecular imaging and therapeutic functions

Farzin¹,

Sheibani²,

Moassesi³

et al. 2018

J Biomedical Materials Res

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“…Common applications for Cu(I) complexes include OLEDs [12][13][14][15], catalysts [16][17][18], bioimages [19][20][21], gas sensors [22][23][24][25], vapochromic sensors [26][27][28][29], and solvatochromic sensors [30,31]. For the two lattermost applications, the compounds exhibit color changes and, in some cases, changes in emission properties when exposed to vapors of volatile organic compounds (VOCs) [32][33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

New emissive mononuclear copper (I) complex: Structural and photophysical characterization focusing on solvatochromism, rigidochromism and oxygen sensing in mesoporous solid matrix

Ravaro

Mafud

et al. 2018

Dyes and Pigments

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We report the structural and photophysical property analyses of a new emissive copper (I) complex CuI(PPh3)(L) (1, L = 4,4'-dimethoxy-2,2'-bipyridine) which demonstrates solvatochromism. When recrystallized from acetonitrile, the originally orange color of 1 becomes yellow and demonstrates a blue-shifted, broad emission spectrum. This process is reversed when the yellow solid is redissolved in dichloromethane and recrystallized. The lattice parameters and angles found were a = 17.769 Å, β = 114.05 o and a = 11.555 Å, angle β = 92.70 o for the orange and yellow forms of 1, respectively, and there are notable structure differences for CuI(PPh3)(L) in these two solids. When loaded into a mesoporous silica, the emission blue shift becomes greater, indicating a strong rigidochromic effect at room temperature. The emission from such copper complex loaded mesoporous silica matrix is quenched by oxygen and this quenching has been quantified.

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Grafting of [64Cu]-TPPF20 porphyrin complex on Functionalized nano-porous MCM-41 silica as a potential cancer imaging agent

Cited by 34 publications

References 39 publications

Nanoparticulate formulations of radiopharmaceuticals: Strategy to improve targeting and biodistribution properties

Nanoparticulate formulations of radiopharmaceuticals: Strategy to improve targeting and biodistribution properties

An overview of nanoscale radionuclides and radiolabeled nanomaterials commonly used for nuclear molecular imaging and therapeutic functions

New emissive mononuclear copper (I) complex: Structural and photophysical characterization focusing on solvatochromism, rigidochromism and oxygen sensing in mesoporous solid matrix

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