Grafting of niclosamide and salicylanilide onto hydrophilic polyurethane for the control of fungal and barnacle growth

Chung, Yong‐Chan; Kim, Jin Chul; Kim, Dong Eui; Choi, Jae Won; Chun, Byoung Chul

doi:10.1007/s00289-018-2481-0

Cited by 4 publications

(1 citation statement)

References 37 publications

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“…Several topical formulations of niclosamide were also described and can be possible strategies to treat fungal skin infections [ 44 , 45 , 46 ]. Moreover, the grafting of niclosamide onto polymers such as hydrophilic polyurethane was described as a suitable strategy to obtain antifungal polymers [ 47 ]. However, these formulations require thorough clinical evaluation since they can also change adverse pharmacological properties of niclosamide, such as toxicities and other side effects [ 15 ].…”

Section: Niclosamide: Chemistry Pharmacology and Antifungal Activitymentioning

confidence: 99%

The Antifungal Potential of Niclosamide and Structurally Related Salicylanilides

Biersack

2024

IJMS

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Human mycoses cover a diverse field of fungal diseases from skin disorders to systemic invasive infections and pose an increasing global health problem based on ineffective treatment options, the hampered development of new efficient drugs, and the emergence of resistant fungal strains. Niclosamide is currently applied for the treatment of worm infections. Its mechanisms of action, which include the suppression of mitochondrial oxidative phosphorylation (also known as mitochondrial uncoupling), among others, has led to a repurposing of this promising anthelmintic drug for the therapy of further human diseases such as cancer, diabetes, and microbial infections. Given the urgent need to develop new drugs against fungal infections, the considerable antifungal properties of niclosamide are highlighted in this review. Its chemical and pharmacological properties relevant for drug development are also briefly mentioned, and the described mitochondria-targeting mechanisms of action add to the current arsenal of approved antifungal drugs. In addition, the activities of further salicylanilide-based niclosamide analogs against fungal pathogens, including agents applied in veterinary medicine for many years, are described and discussed for their feasibility as new antifungals for humans. Preliminary structure–activity relationships are determined and discussed. Various salicylanilide derivatives with antifungal activities showed increased oral bioavailabilities when compared with niclosamide. The simple synthesis of salicylanilide-based drugs also vouchsafes a broad and cost-effective availability for poorer patient groups. Pertinent literature is covered until 2024.

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Section: Niclosamide: Chemistry Pharmacology and Antifungal Activitymentioning

confidence: 99%

The Antifungal Potential of Niclosamide and Structurally Related Salicylanilides

Biersack

2024

IJMS

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Grafted Polyurethane Copolymers with Notable Changes in Tensile and Shape Memory Properties upon Addition of Acid and Base

et al. 2020

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Vascularized adipose construction via low-fouling shape memory scaffold

Zhang

et al. 2023

Chemical Engineering Journal

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Grafting of niclosamide and salicylanilide onto hydrophilic polyurethane for the control of fungal and barnacle growth

Cited by 4 publications

References 37 publications

The Antifungal Potential of Niclosamide and Structurally Related Salicylanilides

The Antifungal Potential of Niclosamide and Structurally Related Salicylanilides

Grafted Polyurethane Copolymers with Notable Changes in Tensile and Shape Memory Properties upon Addition of Acid and Base

Vascularized adipose construction via low-fouling shape memory scaffold

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