Grafting of vinyl monomers on the surface of a poly(ethylene terephthalate) film using Ar plasma-post polymerization technique to increase biocompatibility

Sugiyama, Kazuo; Kato, K.; Kido, Masakazu; Shiraishi, Kohei; Ohga, Koji; Okada, Kiyotaka; Matsuo, Osamu

doi:10.1002/macp.1998.021990636

Cited by 4 publications

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“…The generated peroxides on the surface of poly(ethylene terephthalate) film were detected by the 2,2-diphenyl-1-picrylhydrazyl method described in a previous paper. [1] From the results of preliminary experiments carried out in various condition according to previous work for poly(ethylene terephthalate) films [1] , the conditions determined as optimum for the Ar plasma treatment are as follows; initial pressure: 1.3 Pa, RF power: 5 W, Ar flow rate: 0.04 sccm, irradiation time: 2 min. The water soluble polymer grafted polyethylene (g-PE) films were obtained as described in the Experimental part.…”

Section: Preparation and Characterization Of G-pe Filmsmentioning

confidence: 99%

“…[10,27] It can be said from these results that a few proteins are adsorbed on the PMPC-g-PE film based on a hydrogel structure formed by PMPC segments. [1] …”

Section: Adsorption Of Protein On the Modified Pe Filmmentioning

confidence: 99%

“…The biocompatibility of polymer materials was evaluated by several ways such as the adsorption of plasma protein, [28] inhibition activity of fibrin formation using the activated partial thromboplastin reagent, [1] the platelet aggregation by the addition of adenosine 59-diphosphate sodium salt, [29] the enzymatic reaction of thrombin and synthetic choromogenic substrate S-2238 [20] as well as platelet adhesion and activation. [30,31] In this paper, as the enzymatic method is the most suitable way for the evaluation of water soluble polymer, the biocompatibility was evaluated from the degree of inhibition of thrombin activity by the addition of S-2238 in the presence of 1 wt.-% of water soluble polymer described in Fig.…”

Section: Enzymatic Reaction Of Thrombin and S-2238 In The Presence Ofmentioning

confidence: 99%

“…A variety of concepts have been described to improve the biocompatibility of polymers: a) introduction of a hydrogel structure to a polymer surface, [1][2][3] b) fabrication of a microphase separation structure, [4,5] and c) immobilization of a potent natural anticoagulant to polymer. [6][7][8][9] In particular, since a hydrogel has physical properties similar to human tissue and may exhibit an excellent biocompatibility, a number of workers have made a significant effort to modify the surface of polymer substrates with hydrogel forming polymers such as poly [2-(methacryloyloxy)ethyl phosphorylcholine] (PMPC), [1,[10][11] poly [2-(glucosyloxy)ethyl methacrylate] (PGEMA), [2,3] polyoxyethylene (POE), [12] poly(N-isopropylacrylamide) (PNIPAAm) [13] and poly[N-(2-hydroxypropyl) methacrylamide] (PHPMA), [14,15] the structures are shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

“…[1,[16][17][18][19] We already reported the grafting of PMPC and PGEMA segments on the surface of a poly(ethylene terephthalate) film using Ar plasma-post polymerization technique to increase biocompatibility. [1] As a part of our work on biocompatible polymers such as PMPC, [1] PGEMA [2] and PHPMA, [14] our interest was focused on the graft copolymerization of biocompatible monomers onto the polyethylene surface by means of Ar plasma-post polymerization technique. The purpose of the present work is to evaluate the biocompatibility of the polyethylene (g-PE) films modified with PMPC, PGEMA, PNIPAAm and PHPMA segments by measurements of the adsorption of serum proteins and the rate of enzymatic reaction of thrombin with a synthetic substrate S-2238.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of biocompatibility of the surface of polyethylene films modified with various water soluble polymers using Ar plasma-post polymerization technique

Sugiyama

Matsumoto

Yamazaki

2000

Macromol. Mater. Eng.

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Section: Preparation and Characterization Of G-pe Filmsmentioning

confidence: 99%

“…[10,27] It can be said from these results that a few proteins are adsorbed on the PMPC-g-PE film based on a hydrogel structure formed by PMPC segments. [1] …”

Section: Adsorption Of Protein On the Modified Pe Filmmentioning

confidence: 99%

Section: Enzymatic Reaction Of Thrombin and S-2238 In The Presence Ofmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of biocompatibility of the surface of polyethylene films modified with various water soluble polymers using Ar plasma-post polymerization technique

Sugiyama

Matsumoto

Yamazaki

2000

Macromol. Mater. Eng.

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UV‐Assisted Surface Modification of Polybutadiene with Phosphorus‐Containing Groups

Buchgraber

Svagera

Ebel

et al. 2007

Macro Chemistry & Physics

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A new method for the modification of polymer surfaces with phosphorus‐containing groups is described. Films of polybutadiene were UV‐irradiated in the presence of PBr3 vapor as a photoreactive agent. After subsequent reaction with water under aerobic conditions, phosphonic acid groups were present at the surface. Similarly, methanolysis yielded phosphonic acid esters at the polymer surface. These conversions have been evidenced by IR and XPS. Using contact masks, a patterned modification with phosphorus‐containing groups was achieved. The UV‐induced attachment of phosphonic acid groups onto polymer surfaces is a way towards biocompatible surfaces, e.g. for prosthetic materials.magnified image

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The synthesis and evaluation of pendant oligosaccharide-lipid side chain copolymer

et al. 2003

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In this research, the in vitro anti-thrombogenecity of artificial materials was evaluated using hydrophilic/ hydrophobic copolymers containing oligosaccharide as hydrophilic moiety and phospholipid as hydrophobic moiety respectively. N-(p-vinylbenzyl)-[O-α-D-glucopyranosyl-(1 →4)] n-1 -D-glucoamide (VM7A) was adopted as hydrophilic oligosaccharide and 2-acryloxybutyl-2-(triethylammonium)ethyl phosphoric acid (HBA-choline) was adopted as hydrophobic phospholipid. Copolymers having various monomer feeding molar ratios were synthesized through radical polymerization. The synthesized copolymers were identified using FT-IR, 1 H-NMR, XPS, and DSC. The surface energy of the copolymers were evaluated by dynamic contact angle (DCA) method and checked different roles of VM7A as hydrophilic moiety and HBA-choline as hydrophobic moiety on surface. The surface morphological differences between hydrated and unhydrated surfaces of copolymers were observed and evaluated using AFM. The platelets were separated from canine whole blood by centrifugation and adopted to the anti-thromobogenecity test of the copolymers. From the results, we find out that as VM7A ratio increases, so did anti-thrombogenecity. Such results show the possibility of using these copolymers as blood compatible materials in living body.

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Grafting of vinyl monomers on the surface of a poly(ethylene terephthalate) film using Ar plasma-post polymerization technique to increase biocompatibility

Cited by 4 publications

References 0 publications

Evaluation of biocompatibility of the surface of polyethylene films modified with various water soluble polymers using Ar plasma-post polymerization technique

Evaluation of biocompatibility of the surface of polyethylene films modified with various water soluble polymers using Ar plasma-post polymerization technique

UV‐Assisted Surface Modification of Polybutadiene with Phosphorus‐Containing Groups

The synthesis and evaluation of pendant oligosaccharide-lipid side chain copolymer

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