Grafting Onto Biopolymers

Soni, Saundray Raj; Ghosh, Animesh

doi:10.1016/b978-0-12-810462-0.00009-0

Cited by 7 publications

(1 citation statement)

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“…Polymeric nanoparticles exhibit suitable physical, chemical, and biological properties for applications as nanocarriers 5 . Biopolymers are an excellent source to develop biomaterials that can be used as drug delivery systems 6 . Collagen is the most abundant protein in animals and it is located in connective tissue of the human body.…”

Section: Introductionmentioning

confidence: 99%

Desarrollo De Nanopartículas De Quitosano-Gelatina Y Quitosano-Colágeno Para Liberación De Fármacos

Carlos Salazar,

Vega Chacón,

Amaro Martins

et al. 2023

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Polymeric nanoparticles have demonstrated a great potential for biomedical application, especially in drug delivery systems acting as nanocarriers. The polymers obtained from living organisms, known as biopolymers, are promising materials for these purposes since they present biodegradability, biocompatibility and low immunogenicity, which are features required for in vivo applications. In this work, polymeric nanoparticles were prepared from mixtures of biopolymers such as chitosan, collagen and gelatin by ionic reticulation with sodium tripolyphosphate. Picric acid as a model drug was encapsulated into the nanoparticles. Chitosan of 50.4 kDa of molecular weight and 81 % of deacetylation degree was prepared through the deacetylation and depolymerization of chitin extracted from squid pens (Loligo sp). The composition, size distribution, and surface charge of the prepared nanoparticles were evaluated. Moreover, the influence of the nanoparticles mass and picric acid concentration were analyzed during the loading process by determining of the loaded content and the incorporation efficiency. Maximum loaded contents of picric acid were 7.16 % and 6.45 % for chitosan/gelatin nanoparticles and chitosan/collagen nanoparticles, respectively. In vitro release tests showed a quick picric acid release in chitosan/gelatin nanoparticles. The nanoparticles prepared with collagen took longer time to release the picric acid. Kinetic studies, using mathematical models, revealed that the release takes place through a diffusion mechanism.

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Section: Introductionmentioning

confidence: 99%

Desarrollo De Nanopartículas De Quitosano-Gelatina Y Quitosano-Colágeno Para Liberación De Fármacos

Carlos Salazar,

Vega Chacón,

Amaro Martins

et al. 2023

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Saccharide‐based nanocarriers for targeted therapeutic and diagnostic applications

Mukwaya

Wang

Dou

2018

Polymer International

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Many therapeutic and diagnostic agents suffer from short circulation times or poor selectivity resulting in the need for frequent drug administration and adverse side‐effects. On this basis, selective nanocarriers have been used to address most of the drawbacks via the encapsulation or conjugation of therapeutic and diagnostic agents to allow the targeted release of cargo to diseased sites or tumours, while maintaining low levels of cytotoxicity. Saccharides, which can be classified as monosaccharides, disaccharides and oligo/polysaccharides, have demonstrated great potential in the construction of nanocarriers, as well as the targeted guidance of the nanocarriers to diseased tissues. The fabrication of nanocarriers from natural materials such as polysaccharides affords biodegradability and biocompatibility, and in some instances confers targeting capabilities. The most recent progress in saccharide‐based targeted nanocarriers fabricated via facile one‐pot routes or complex two‐pot synthetic routes is reviewed here, with a particular focus on the high efficiency and flexibility of the one‐pot approach. In addition, inspired by the self‐assembly processes involving saccharides that occur in living organisms, particular emphasis is placed on disease‐targeting nanocarriers that are constructed from or modified by saccharides. © 2018 Society of Chemical Industry

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Carbohydrate Therapeutics Based on Polymer-Grafted Glyconanoparticles: Synthetic Methods and Applications

Kunduru

Jana

2019

Materials Horizons: From Nature to Nanomaterials

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Grafting Onto Biopolymers

Cited by 7 publications

References 151 publications

Desarrollo De Nanopartículas De Quitosano-Gelatina Y Quitosano-Colágeno Para Liberación De Fármacos

Desarrollo De Nanopartículas De Quitosano-Gelatina Y Quitosano-Colágeno Para Liberación De Fármacos

Saccharide‐based nanocarriers for targeted therapeutic and diagnostic applications

Carbohydrate Therapeutics Based on Polymer-Grafted Glyconanoparticles: Synthetic Methods and Applications

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