Graham Little–Piccardi–Lassueur syndrome associated with androgen insensitivity syndrome (testicular feminization)

Gutiérrez, Jesús Vega; Miranda‐Romero, A.; Milán, F Pérez; García, Gerardo

doi:10.1111/j.1468-3083.2004.00945.x

Cited by 25 publications

(24 citation statements)

References 9 publications

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“…Genetic, viral, and hormonal hypotheses have been proposed. 15,17,18 The overlap observed between FFA and PLGLS (specifically in our case) suggests that FFA and PLGLS may share characteristics that could suggest they may be phenotypically related. Based on this, we recommend that any patient who presents with FFA should undergo a full body examination to check for the presence of follicular lesions and nonscarring alopecia.…”

Section: Discussionmentioning

confidence: 89%

Frontal fibrosing alopecia presenting with components of Piccardi-Lassueur-Graham-Little syndrome

Abbas

Chedraoui

Ghosn

2007

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 89%

Frontal fibrosing alopecia presenting with components of Piccardi-Lassueur-Graham-Little syndrome

Abbas

Chedraoui

Ghosn

2007

Journal of the American Academy of Dermatology

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“…In a search of MEDLINE literature in any language published during 1951–2009, Walsh found fewer than 40 cases of GLPLS 7 . I searched MEDLINE, Google Scholar, and Web of Science and found seven published cases of GLPLS in men 1,8–13 . The onset of disease occurred at 26–52 years of age.…”

Section: Discussionmentioning

confidence: 99%

Graham‐Little–Piccardi–Lasseur syndrome: case report and review of the syndrome in men

Laszlo

2013

Int J Dermatology

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Graham-Little-Piccardi-Lasseur syndrome (GLPLS) is a rare lichenoid dermatosis characterized by progressive cicatricial alopecia of the scalp, the loss of pubic and axillary hair, and keratosis pilaris. The syndrome is considered a form of follicular lichen planus. 1 Clinically, GLPLS is characterized by a triad of features that include scarring alopecia of the scalp, non-cicatricial alopecia of the axillae and pubis, and a lichenoid follicular eruption. It was initially described by Piccardi in 1913 and in 1915, Graham-Little published a similar case observed by Lassueur. 2 Case reportA 38-year-old man presented with a pruritic eruption that involved the trunk and upper extremities and had appeared over the previous three weeks. At the consultation, follicular, dark red, spiny, hard, and adherent papules measuring 1-3 mm in diameter were observed. Some of these papules were massed in groups located on the inside of both arms and on the patient's back (Fig. 1a, b). Linear excoriations and some pustules, probably arising in response to a secondary infection caused by itching, were also observed. Over the past five years, the patient had noted patchy hair loss that developed and progressed slowly, without any local or general symptoms. On examination, patches of non-scarring alopecia were observed in the right axilla and the suprapubic area (Fig. 1c, d). This axillary and pubic hair loss had developed over the previous two years.Patches of scarring alopecia without erythema were apparent on the scalp (Fig. 2). The patchy hair loss on the scalp had been diagnosed as alopecia areata, and the patient had been treated with local steroids and vasodilators without effect. He had not been treated for the hair loss in the axillary and pubic areas. However, in the year immediately prior to presentation, the patient had not taken any medication for the disease. He was not concerned about the disease but was distressed about the severe pruritus caused by the most recent cutaneous eruption. The patient denied any constitutional symptoms. His medical history was unremarkable. A general clinical examination of systems and organs found nothing relevant. No specific laboratory data were found. A biopsy of one of the new eruptive lesions revealed a follicular lichen planus. Histopathology described a dense perifollicular lymphocytic infiltrate, extending into the basal layer, with a focal vacuolar alteration of the follicular basement membrane (Fig. 3). Based on the clinical presentation of cicatricial alopecia on the scalp and non-cicatricial alopecia in the axillary and pubic areas, and the histopathologic confirmation of follicular lichen planus, GLPLS was diagnosed. DiscussionGraham-Little-Piccardi-Lasseur syndrome is a rare lichenoid dermatosis. Most patients present with clinical findings commonly considered to represent the triad of findings in GLPLS in the following order: multifocal cica-1019 ª

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“…[4] Few isolated cases with a familial pattern, association with hepatitis B vaccination, and phenotypically female (genetically XY) patient with androgen insensitivity syndrome (testicular feminization) have been documented. [5–7] Altered integrin expression, which has been shown in active LPP lesions, could explain the phenomenon of anagen hair on pull test. [2]…”

Section: Discussionmentioning

confidence: 99%

Graham-Little Piccardi Lassueur syndrome: An unusual variant of follicular lichen planus

et al. 2011

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Graham Little-Piccardi-Lassueur syndrome is a type of lichen planopilaris (follicular lichen planus) characterized by the triad of patchy cicatricial alopecia of the scalp, noncicatricial alopecia of the axilla and groin, and a follicular spinous papule on the body, scalp, or both. It is four times more common in females in the age group of 30-70 years. Only a few cases have been reported in literature wherein the disease has affected males. Herein we report a young male who presented with features of Graham Little-Piccardi-Lassueur syndrome.

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Graham Little–Piccardi–Lassueur syndrome associated with androgen insensitivity syndrome (testicular feminization)

Cited by 25 publications

References 9 publications

Frontal fibrosing alopecia presenting with components of Piccardi-Lassueur-Graham-Little syndrome

Frontal fibrosing alopecia presenting with components of Piccardi-Lassueur-Graham-Little syndrome

Graham‐Little–Piccardi–Lasseur syndrome: case report and review of the syndrome in men

Graham-Little Piccardi Lassueur syndrome: An unusual variant of follicular lichen planus

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