Gram-scale synthesis of highly biocompatible and intravenous injectable hafnium oxide nanocrystal with enhanced radiotherapy efficacy for cancer theranostic

Li, Yangyang; Qi, Yuchen; Zhang, Hongbo; Xia, Zhihao; Xie, Tingting; Li, Wanlin; Zhong, Danni; Zhu, Huanle; Zhou, Min

doi:10.1016/j.biomaterials.2019.119538

Cited by 74 publications

(61 citation statements)

References 50 publications

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“…Importantly, the high‐Z metal Hf in Hb@Hf‐Ce6 NPs can be used as a radiosensitizer to enhance RT‐RDT performance by ROS generation. [ 18 ] Intracellular ROS production in 4T1 cells was detected via the 2,7‐dichlorofluorescin diacetate (DCFH‐DA) fluorescent probe. As showed in Figure 3d, the intracellular fluorescence intensities of dichlorodihydrofluorescein (DCF) in cells treated with Hb@Hf‐Ce6 NPs under X‐ray irradiation (NP+X‐ray) were obviously higher than other groups, indicating that Hb@Hf‐Ce6 NPs exhibited the best performance on RT‐RDT effectiveness by augmenting the ROS production.…”

Section: Resultsmentioning

confidence: 99%

Oxygen‐Enriched Metal‐Phenolic X‐Ray Nanoprocessor for Cancer Radio‐Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy

et al. 2020

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Radiotherapy (RT) based on DNA damage and reactive oxygen species (ROS) generation has been clinically validated in various types of cancer. However, high dose-dependent induced toxicity to tissues, non-selectivity, and radioresistance greatly limit the application of RT. Herein, an oxygen-enriched X-ray nanoprocessor Hb@Hf-Ce6 nanoparticle is developed for improving the therapeutic effect of RT-radiodynamic therapy (RDT), enhancing modulation of hypoxia tumor microenvironment (TME) and promoting antitumor immune response in combination with programmed cell death protein 1 (PD-1) immune checkpoint blockade. All functional molecules are integrated into the nanoparticle based on metal-phenolic coordination, wherein one high-Z radiosensitizer (hafnium, Hf) coordinated with chlorin e6 (Ce6) modified polyphenols and a promising oxygen carrier (hemoglobin, Hb) is encapsulated for modulation of oxygen balance in the hypoxia TME. Specifically, under single X-ray irradiation, radioluminescence excited by Hf can activate photosensitizer Ce6 for ROS generation by RDT. Therefore, this combinatory strategy induces comprehensive antitumor immune response for cancer eradication and metastasis inhibition. This work presents a multifunctional metal-phenolic nanoplatform for efficient X-ray mediated RT-RDT in combination with immunotherapy and may provide a new therapeutic option for cancer treatment.

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Section: Resultsmentioning

confidence: 99%

Oxygen‐Enriched Metal‐Phenolic X‐Ray Nanoprocessor for Cancer Radio‐Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy

et al. 2020

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“…One of the manifestations of COVID-19 is fulminant disease characterized by sepsis [ 49 ]. For example, COVID-19 can cause uncontrolled inflammatory response characterized by prominent pro-inflammatory cytokine release in patients with severe COVID-19 [ 50 , 51 ]. Ivan Cekerevac et al evaluated the concentrations of RONS, as well as the activity of enzymes of the antioxidative defense system in COVID-19 patients, and confirmed that the levels of O2·-, NO, and catalase activity are differently change in the different severity of COVID-19 infection [ 52 ].…”

Section: The Correlation Between Covid-19 and Sepsismentioning

confidence: 99%

Nanotherapies for sepsis by regulating inflammatory signals and reactive oxygen and nitrogen species: New insight for treating COVID-19

et al. 2021

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SARS-CoV-2 has caused up to 127 million cases of COVID-19. Approximately 5% of COVID-19 patients develop severe illness, and approximately 40% of those with severe illness eventually die, corresponding to more than 2.78 million people. The pathological characteristics of COVID-19 resemble typical sepsis, and severe COVID-19 has been identified as viral sepsis. Progress in sepsis research is important for improving the clinical care of these patients. Recent advances in understanding the pathogenesis of sepsis have led to the view that an uncontrolled inflammatory response and oxidative stress are core factors. However, in the traditional treatment of sepsis, it is difficult to achieve a balance between the inflammation, pathogens (viruses, bacteria, and fungi), and patient tolerance, resulting in high mortality of patients with sepsis. In recent years, nanomaterials mediating reactive oxygen and nitrogen species (RONS) and the inflammatory response have shown previously unattainable therapeutic effects on sepsis. Despite these advantages, RONS and inflammatory response-based nanomaterials have yet to be extensively adopted as sepsis therapy. To the best of our knowledge, no review has yet discussed the pathogenesis of sepsis and the application of nanomaterials. To help bridge this gap, we discuss the pathogenesis of sepsis related to inflammation and the overproduction RONS, which activate pathogen-associated molecular pattern (PAMP)-pattern recognition receptor (PRR) and damage-associated molecular pattern (DAMP)-PRR signaling pathways. We also summarize the application of nanomaterials in the treatment of sepsis. As highlighted here, this strategy could synergistically improve the therapeutic efficacy against both RONS and inflammation in sepsis and may prolong survival. Current challenges and future developments for sepsis treatment are also summarized.

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“…To date, many kinds of Bi‐based radiation‐driven ROS‐ECBs have been used in RT, such as Bi nanoparticles (Yu et al, 2017), silica‐based bismuth‐gadolinium nanoparticles (Detappe et al, 2017), BiOI quantum dots (Wang, An, Lin, Tian, & Yang, 2020), BSA‐Coated BiOI@Bi 2 S 3 heterojunction nanoparticles (Guo et al, 2017), Au‐Bi 2 S 3 hetero‐nanostructure nanoparticles (Wang et al, 2019), BSA‐Bi 2 Se 3 nanodots (Mao et al, 2016), poly(vinylpyrollidone)‐and selenocysteine‐modified Bi 2 Se 3 nanoparticles (Du et al, 2017), FeSe 2 /Bi 2 Se 3 nanoparticles (Cheng et al, 2016), and MnSe@Bi 2 Se 3 nanoparticles (Song et al, 2015). Besides, tungsten (W)‐, hafnium (Hf)‐, tantalum (Ta)‐, or rhenium (Re)‐based radiation‐driven ROS‐ECBs, such as WO 3‐x nanodots (Wen et al, 2016), WS 2 quantum dots (Wang, Song, Zhang, & Zhang, 2019), HfO 2 nanoparticles (Li et al, 2020), TaO x nanospheres (Peng et al, 2020), and ReS 2 ‐PEG nanosheets (Shen et al, 2017) have also been fabricated and investigated for enhanced the therapeutic outcomes.…”

Section: Energy‐converting Biomaterials For Cancer Therapymentioning

confidence: 99%

Energy‐converting biomaterials for cancer therapy: Category, efficiency, and biosafety

Dong

Sun

et al. 2020

WIREs Nanomed Nanobiotechnol

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Energy‐converting biomaterials (ECBs)‐mediated cancer‐therapeutic modalities have been extensively explored, which have achieved remarkable benefits to overwhelm the obstacles of traditional cancer‐treatment modalities. Energy‐driven cancer‐therapeutic modalities feature their distinctive merits, including noninvasiveness, low mammalian toxicity, adequate therapeutic outcome, and optimistical synergistic therapeutics. In this advanced review, the prevailing mainstream ECBs can be divided into two sections: Reactive oxygen species (ROS)‐associated energy‐converting biomaterials (ROS‐ECBs) and hyperthermia‐related energy‐converting biomaterials (H‐ECBs). On the one hand, ROS‐ECBs can transfer exogenous or endogenous energy (such as light, radiation, ultrasound, or chemical) to generate and release highly toxic ROS for inducing tumor cell apoptosis/necrosis, including photo‐driven ROS‐ECBs for photodynamic therapy, radiation‐driven ROS‐ECBs for radiotherapy, ultrasound‐driven ROS‐ECBs for sonodynamic therapy, and chemical‐driven ROS‐ECBs for chemodynamic therapy. On the other hand, H‐ECBs could translate the external energy (such as light and magnetic) into heat for killing tumor cells, including photo‐converted H‐ECBs for photothermal therapy and magnetic‐converted H‐ECBs for magnetic hyperthermia therapy. Additionally, the biosafety issues of ECBs are expounded preliminarily, guaranteeing the ever‐stringent requirements of clinical translation. Finally, we discussed the prospects and facing challenges for constructing the new‐generation ECBs for establishing intriguing energy‐driven cancer‐therapeutic modalities. This article is categorized under: Nanotechnology Approaches to Biology >Nanoscale Systems in Biology

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Gram-scale synthesis of highly biocompatible and intravenous injectable hafnium oxide nanocrystal with enhanced radiotherapy efficacy for cancer theranostic

Cited by 74 publications

References 50 publications

Oxygen‐Enriched Metal‐Phenolic X‐Ray Nanoprocessor for Cancer Radio‐Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy

Oxygen‐Enriched Metal‐Phenolic X‐Ray Nanoprocessor for Cancer Radio‐Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy

Nanotherapies for sepsis by regulating inflammatory signals and reactive oxygen and nitrogen species: New insight for treating COVID-19

Energy‐converting biomaterials for cancer therapy: Category, efficiency, and biosafety

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