Granisetron and Ondansetron on Post Operative Nausea and Vomiting in Laparoscopic Cholecystectomy Under General Anesthesia At Bir Hospital Kathmandu, Nepal

Abstract

IntroductionLaparoscopic cholecystectomy has higher incidence of postoperative nausea and vomiting (PONV). In routine practice single dose of drug is given prophylactically during the surgery.ObjectiveThis study aimed to compare the antiemetic efficacy of two different 5-hydroxytryptamine-3 (5HT3) receptor antagonists, Ondansetron and Granisetron when given prophylactically to patients undergoing laparoscopic cholecystectomy.MethodologyIt was a randomized, single blind study, conducted in 75 patients undergoing laparoscopic cholecystectomy. Patients were divided into two groups: Group O and Group G. Patients in group O were given 0.1 mg/kg Ondansetron intravenously (IV) and patients in Group G were given 0.04 mg/kg Granisetron. The standard general anesthetic technique was administered to all the patients. Episodes of nausea, retching and vomiting were assessed during the first 24 hours after anesthesia. Collected data was applied with appropriate test in SPSS 16 and overall significance level was considered at 95% confidence interval (p ≤ 0.05).ResultsThere was no statistically significant difference for demographic data among the two groups (P>0.05). Both drugs were similarly effective in first four hours (P>0.05). Between 4–12 hours and 12-24 hours, episodes of nausea and vomiting were higher in Ondansetron group.ConclusionThe incidence of PONV was significantly high in Ondansetron than in Granisetron given prophylactically in laparoscopic cholecystectomy. Birat Journal of Health SciencesVol.2/No.1/Issue 2/ Jan - April 2017, page: 175-178

Comparative Study of Ondansetron and Granisetron for Preventing Post-Operative Nausea and Vomiting in Laparoscopic Cholecystectomy under General Anaesthesia

“…In the study done by Ommid et al, incidence of PONV was 29% 18 and that in study by Bhattarai et al was 26%. 10 The results were similar to this study. Study done by Bhattacharya et al found the incidence of PONV in Granisetron group to be 7%.…”

“…Similar incidence was found in study done by Bhattarai et al (54%) and Ommid et al (52%). 10,18 Study done by Bhattacharya et al found the incidence of PONV in Ondansetron group was 10%. 19 This difference in incidence in PONV might be because they conducted study in day care gynaecological laparoscopy and shorter duration of surgery.…”

“…The incidence of PONV in laparoscopic cholecystectomy (LC) under general anaesthesia with the use of Ondansetron and Granisetron prophylactically according to Bhattarai et al was 54% and 26% respectively. 10 The sample size was calculated at a level of significance of 5% and power of 80% by using the following formula;…”