Granular cell basal cell carcinoma

Dundr, Pavel; Štork, Jiří; Povýšil, C; Vosmík, F

doi:10.1111/j.1440-0960.2004.00034.x

Cited by 17 publications

(21 citation statements)

References 9 publications

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“…The vesicles responsible for morphologic change of the cytoplasm had ultrastructural features of lysosomes and represent either true lysosomes or infoldings of the cytoplasmic membrane subsequently phagocytosed and digested by lysosomes . Expression of CD68 (KP1 clone), a glycoprotein epitope associated with lysosomal membranes, was documented by immunohistochemical studies in one previously reported tumor…”

Section: Discussionmentioning

confidence: 94%

“…The prototypical dermal neoplasm with granular cell features is the so‐called granular cell tumor , which because of its expression of S100 protein is thought to be of Schwann cell lineage . Granular cell features, however, have been reported in many different tumor types, including leiomyoma, leiomyosarcoma, atypical fibroxanthoma, angiofibroma, dermatofibroma, dermatofibrosarcoma protuberans, melanoma, non‐neural granular cell tumor (primitive polypoid granular cell tumor), angiosarcoma and BCC …”

Section: Discussionmentioning

confidence: 99%

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Multiple lesions of granular cell basal cell carcinoma: a case report

Jedrych

Busam

2013

J Cutan Pathol

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Granular cell change in basal cell carcinoma (BCC) occurs rarely. Only 11 such cases have been reported; all of them were solitary nodular BCC. We report herein a case of multiple granular cell BCC with infundibulocystic features. The tumors presented as papules on the anterior neck of a 44-year-old female with a prior history of a well-differentiated squamous cell carcinoma (SCC) of the tongue and radiation involving the area in which BCC developed. Microscopically, the tumors were circumscribed small dermal nodules composed of epithelial cords with granular eosinophilic cytoplasm and entrapped infundibular keratocysts. Given the eosinophilic appearance of the tumor, history of SCC and the lesions multiplicity, the initial biopsy was first interpreted as metastatic SCC. The correct diagnosis of granular cell BCC was established upon rereview of the slides at a cancer center. Given the diagnostic controversy, immunohistochemical stains were performed. The tumor cells expressed Ber-EP4, CD63 (NKI/C3) and CD68. The tumors were compared to the prior SCC finding different morphologies. Extensive clinical evaluation showed no evidence of recurrent SCC. This report expands the clinicopathologic spectrum of granular cell variant of BCC and documents for the first time eruption of multiple such tumors in a localized area.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Multiple lesions of granular cell basal cell carcinoma: a case report

Jedrych

Busam

2013

J Cutan Pathol

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“…Reactivity for these lysosome-associated immunohistochemical markers has also been reported in other granular-cell tumours [19,20,21]. Monoclonal antibody KP1 recognizes an epitope of CD68 antigen with lysosomal membranes.…”

Section: Discussionmentioning

confidence: 99%

Fibrous Papule of the Face with Granular Cells

2007

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Fibrous papule of the face is a common benign lesion located most often on the nose. It presents usually as a single small, firm, skin-coloured papule and is often misdiagnosed as melanocytic naevus, wart or small nodular basal cell carcinoma. Histopathologically, the lesions are characterized by involvement of the upper dermis by a fibrovascular proliferation and scattered triangular or stellate, often multinucleated cells. Uncommon histopathologic variants of fibrous papule of the face include hypercellular, clear-cell, pleomorphic, pigmented, inflammatory and granular-cell types. We present here a patient with the syndrome of familial cancer and fibrous papule of the face with granular cells. The granules stained strongly with PAS stain, as well as with CD68 and NKI/C3 immunostains, whereas S-100 protein resulted negative. In our patient the mutations in the 2 most often affected DNA mismatch repair genes of Muir-Torre syndrome were not found, therefore the origin of the familial cancer syndrome remains unknown. Probably the occurrence of the granular-cell fibrous papule of the face was coincidental.

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“…SMA) while being negative for S100 4 . Granular cell basal cell carcinoma has been well documented and shows the basal palisading found in its non‐granular counterpart while retaining positivity for some cytokeratins and Ber‐EP4 5–7 . Granular cell atypical fibroxanthoma has been described in chronically sun‐damaged skin of elderly patients and is negative for the S100 antigen 8 .…”

Section: Discussionmentioning

confidence: 99%

“…In cutaneous sites, strong S100 positivity raises the possibility of melanocytic origin. Also, the coarse cytoplasmic granularity typical of GCT has been documented in neoplasms of various histogenetic lineages including melanocytic neoplasms 2–13 . The differential diagnosis therefore, of S100‐positive cutaneous lesions with granular cell morphology, includes both melanocytic neoplasms and cutaneous GCT.…”

mentioning

confidence: 99%