Granular cell dermatofibroma

Zelger, Bettina; Steiner, H; Kutzner, Heinz; Rütten, Arno

doi:10.1046/j.1365-2559.1997.2490854.x

Cited by 43 publications

(29 citation statements)

References 15 publications

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“…Positive immunostaining with CD68 in granular cell tumors cannot be considered a marker of histiocytic derivation but seems to correlate with the presence of lysosomes [25]. The results of our ultrastructural studies were substantially similar to those obtained by other authors [12, 13, 14]underlining the fibroblastic nature of the granular cells. The significance of the cellular granularity in DF as well as in other cutaneous tumors remains unclear.…”

Section: Discussionsupporting

confidence: 88%

“…The proportion of granular cell component can range from 30% as in our cases to more than 90% of the lesion [12, 14]. In some cases granular cells are arranged in well-defined islands whereas in other cases a gradual transition between granular cells and spindle cells is observed [13, 14].…”

Section: Discussionmentioning

confidence: 93%

“…In the last few years, uncommon specific variants of DF with distinctive histologic features have been delineated including DF with monster cells [1], DF with palisading nuclei [2], with osteoclast-like giant cells [3], DF with clear cells [4], sclerotic [5], xanthomized [6], atrophic [7], fibrous DF [8]and the deep variant [9]. Among the histopathologic spectrum of this benign fibrohistiocytic proliferation, DF with granular cells represents a new histologic variant originally described by LeBoit and Barr [10]in 1991 of which only few cases have been reported in the literature [11, 12, 13, 14, 15]. …”

Section: Introductionmentioning

confidence: 99%

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Dermatofibroma with Granular Cells: A Report of Two Cases

Aloi

Albertazzi²,

Pippione³

1999

Dermatology

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We describe two examples of an unusual variant of dermatofibroma (DF) in which areas of granular cells were a prominent feature. The diagnosis of DF was confirmed by immunohistochemistry and by ultrastructural studies. Granular cell changes can be observed in numerous benign and malignant cutaneous tumors of different cellular lineage. Cellular granularity is a nonspecific phenomenon characterized by intracytoplasmic accumulation of lysosomes and may cause diagnostic difficulties. Traumatic factors may be involved in the pathogenesis of cellular granularity.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Dermatofibroma with Granular Cells: A Report of Two Cases

Aloi

Albertazzi²,

Pippione³

1999

Dermatology

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“…Granular cell change in benign fibrous histiocytomas has been described [25]. This change is not predominant and overlaps with conventional features including spindle cells and prominent bundles of collagen.…”

Section: Differential Diagnosismentioning

confidence: 95%

“…The tumor is S-100 negative and the granular cells are NKI/C3 and CD68 positive. Factor XIIIa and SMA reactivity may be seen in about 50 % of the tumors [25]. Clinically, the lesion is rarely polypoid.…”

Section: Differential Diagnosismentioning

confidence: 99%

S-100 Negative Granular Cell Tumor (So-called Primitive Polypoid Non-neural Granular Cell Tumor) of the Oral Cavity

Rawal

Dodson

2016

Head and Neck Pathol

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Four cases of cutaneous S-100 negative granular cell tumor were described in 1991. Until now, only 3 cases of oral involvement have been documented in English literature. Two additional cases of oral S-100 negative granular cell tumor are described. Immunohistochemical markers were applied to exclude other lesions that may show the presence of granular cells. The clinical findings were correlated with the histopathological and immunohistochemical features to arrive at the appropriate diagnosis. S-100 negative granular cell tumors are erythematous polypoid masses commonly mistaken for granulation tissue or a pyogenic granuloma. Any part of the oral cavity may be affected. Histopathologically, the lesions consist of sheets, nests, and fascicles of granular cells that are S-100 negative. The granular cells are non-reactive to SMA, HMB45, Melan A, and CD163. The intracytoplasmic granules are diffusely and strongly positive to NKI/C3. The cell lineage of the S-100 negative granular cell tumor is obscure. Absence of staining with CD163 excludes a histiocytic lineage. Absence of staining with S-100 excludes a neural origin. Absence of staining with S-100 and key melanoma markers HMB45 and Melan A also excludes a melanocytic origin. In this context, positive reactivity with NKI/C3 is indicative of presence of intracytoplasmic lysosomal granules only. Greater awareness of this lesion in the oral cavity will result in better characterization of its biologic potential.

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Nerves

2018

Atlas of Dermatopathology

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Granular cell dermatofibroma

Abstract: Our series delineates granular cell dermatofibroma as a distinct clinicopathological variant of fibrohistiocytic tissue response which needs to be distinguished from other tumours with granular cell features.

Cited by 43 publications

References 15 publications

Dermatofibroma with Granular Cells: A Report of Two Cases

Dermatofibroma with Granular Cells: A Report of Two Cases

S-100 Negative Granular Cell Tumor (So-called Primitive Polypoid Non-neural Granular Cell Tumor) of the Oral Cavity

Nerves

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