Granular Cell Myoblastoma Involving the Recurrent Laryngeal Nerve

Weisman, Robert A.; Konrad, Horst R.; Canalis, Rinaldo F.

doi:10.1001/archotol.1980.00790290046015

Cited by 12 publications

(6 citation statements)

References 15 publications

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“…In the head and neck region, MGCTs are usually found in the oral cavity, but case reports have described tumors arising from the recurrent laryngeal nerve, 23 the cervical sympathetic nerve trunk, 29 the retrotracheal space, 30 and in the infratemporal fossa. 31 Furthermore, a case presenting with Eagle syndrome, that is, elicitation of pain on swallowing, turning the head, or extending the tongue caused by irritation of the glossopharyngeal nerve, has been described.…”

Section: Discussionmentioning

confidence: 99%

“…[13][14][15][16][17][18] GCTs are also encountered in the peripheral nervous system and well-documented cases have been published showing involvement of the radial, 19 median, 20 sciatic, 21,22 and recurrent laryngeal nerves. 23 These tumors are usually benign, slowly growing tumors, clinically silent, and mostly incidentally found at autopsy. Fewer than 2% of all GCTs are malignant.…”

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confidence: 99%

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Malignant Granular Cell Tumor of the Skull Base

et al. 2008

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Malignant Granular Cell Tumor of the Skull Base

et al. 2008

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“…In the past there has been controversy about their origin. The most widely held interpretation is that GCT of soft tissue as well as cranial and peripheral nerves are derived from Schwann cells 5,[23][24][25][26][27][28][29] . This origin for peripheral GCT is supported by their positive reaction for S-100 51-57 as well as NSE and PGP9.5 58,59 .…”

Section: Discussionmentioning

confidence: 99%

“…The most common intracranial site is the region of the infundibulum [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] . However, GCT can be found in cranial and peripheral nerves 5,[22][23][24][25][26][27][28][29] as well as within cerebral hemispheres [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Morphological and immunohistochemical characterization of granular cells in non‐hypophyseal tumours of the central nervous system

Rickert¹,

Kuchelmeister

Gullotta³

1997

Histopathology

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We report 14 biopsy cases of granular cell tumours (GCT) of the central nervous system (CNS) outside the pituitary gland. In six cases the granular cells determined the morphology (actual GCT), the other eight consisted of different CNS tumours with a varying granular cell component. Pronounced immunoreactivity for ubiquitin and alpha-1-antichymotrypsin could be found in all investigated tumours, while GFAP, neuron specific enolase, von Willebrand factor, vimentin, S-100 protein, alpha-1-antitrypsin, actin, and the neurofilaments 68 kDa and 160 kDa showed mostly weak positivity in some cases. Four out of eight GCT showed no immunoreactivity for MIB1; the other four cases had a proliferation index between 0.5% and 15%. Six out of nine cases were positive for p53. We consider granular cells to originate from different cell types. Thus, although morphologically identical, GCT are actually biologically heterogeneous. GCT of the CNS may represent gliomas of mostly astrocytic origin with a metabolically induced transformation of some tumour cells into granular cells.

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“…[4,5] To the best of our knowledge, 17 cases of malignant granular cell tumors arising from various peripheral nerves have been reported so far. [4,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] We report a case of a malignant granular cell tumor originating from the ulnar nerve with a good clinical outcome.…”

Section: Introductionmentioning

confidence: 99%

Malignant granular cell tumor of the ulnar nerve: A case report of long-term follow-up and literature review

Morinaga¹,

Yamamoto²,

Hayashi³

et al. 2021

CRCP

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Background: The incidence of malignant granular cell tumor, an extremely rare Schwann cell-derived tumor with a poor prognosis, is reported to be approximately 0.2% of malignant soft tissue tumors. We report a case of a malignant granular cell tumor originating from the ulnar nerve.Case presentation: A 71-year-old woman presented with a mass in her right forearm. Magnetic resonance imaging showed a tumor with homogenous intensity of T1 and heterogeneous hyperintensity of T2, continuous with the ulnar nerve. Incisional biopsy revealed a malignant granular cell tumor, and marginal excision of the tumor was performed. Histologically, the tumor size was 9.2 cm and consisted of eosinophilic, granular polygonal to round and spindle-shaped cells, with vesicular and prominent nucleoli, and increased mitosis. Immunohistochemically, the tumor cells were positive for S-100 protein, CD68, H3K27me3, TFE3, and SOX10 and negative for smooth muscle alpha-actin, desmin, cytokeratin AE1/3, epithelial membrane antigen, and synaptophysin. The Ki-67 positivity rate was 12%. These findings were consistent with those of malignant granular cell tumors. In addition, no metastasis or recurrence was observed 15 years after the excision.Conclusion: Surgical resection is the standard treatment option. In our case, the diagnostic criteria for malignant granular cell tumors were histologically met. Patients with malignant granular cell tumors have a poor prognosis. However, no metastasis or recurrence was observed in this case 15 years after the surgery.

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Granular Cell Myoblastoma Involving the Recurrent Laryngeal Nerve

Cited by 12 publications

References 15 publications

Malignant Granular Cell Tumor of the Skull Base

Malignant Granular Cell Tumor of the Skull Base

Morphological and immunohistochemical characterization of granular cells in non‐hypophyseal tumours of the central nervous system

Malignant granular cell tumor of the ulnar nerve: A case report of long-term follow-up and literature review

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