Granular Cell Tumor: A Clinical Study of 81 Patients

Marcoval, Joaquim; Bauer-Alonso, Andrea; Llobera-Ris, Clàudia; Moreno-Vílchez, Carlos; Penín, R.M.; Bermejo, Josep Oriol

doi:10.1016/j.adengl.2021.02.006

Cited by 12 publications

(23 citation statements)

References 13 publications

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“…Granular cell tumors generally present as single lesions, but the presence of multiple lesions should raise the suspicion for syndromes with which they are associated, such as Noonan syndrome, neurofibromatosis type I, and LEOPARD syndrome (Lentigines, Electrocardiographic conduction defects, Ocular hypertelorism, Pulmonary stenosis, Abnormalities of the genitalia, Retarded (slowed) growth, Deafness) [ 1 , 5 ]. While the majority of cases are benign, 1% to 2% of cases behave malignantly.…”

Section: Discussionmentioning

confidence: 99%

“…Granular cell tumors (GCTs) are rare neoplasms that most commonly affect the skin and subcutaneous tissue [1][2][3], with approximately half found in the head and neck region. While the tongue is commonly involved, only 6% to 10% of head and neck cases occur in the larynx [4].…”

Section: Introductionmentioning

confidence: 99%

“…While the tongue is commonly involved, only 6% to 10% of head and neck cases occur in the larynx [ 4 ]. The majority of GCTs are benign, while malignant GCTs are extremely rare and comprise less than 2% of cases [ 1 ]. Though originally thought to be of muscular origin [ 2 , 5 ], immunohistochemical studies demonstrating positive staining for S100 protein, neuron-specific enolase, and myelin-specific protein indicate they are Schwann cell derivatives [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…GCTs can affect any age group, but are most commonly present during the fourth to sixth decade of life [ 1 , 2 , 5 ] and may be more common in women [ 1 , 4 , 5 ]. They are rarely seen in children, with only 38 pediatric cases of laryngeal GCTs in the literature [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Granular Cell Tumor in a 13-Year-Old Girl

Fraser¹,

Anthony²

2021

Cureus

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Granular cell tumors are rare benign soft-tissue lesions that most commonly occur in the head and neck. They usually present in adulthood and are rarely seen in children. Here we present a 13-year-old girl who experienced symptoms of hoarseness of voice for most of her childhood and was unsuccessfully treated for asthma, acid reflux, allergies, and bronchitis before direct visualization revealed what was initially thought to be a vocal cord cyst. Surgical excision and pathology revealed the unexpected diagnosis of a vocal cord granular cell tumor. The patient has had resolution of dysphonia and is undergoing voice therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Granular Cell Tumor in a 13-Year-Old Girl

Fraser¹,

Anthony²

2021

Cureus

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“…8 However, patients with multiple GCTs were on average younger than those with a single tumor. 16 Familial cases of GCTs and cases of multiple GCTs associated with other somatic defects and genetic syndromes have been reported. 17 The unspecific clinical presentation of GCTs of the skin makes the diagnosis challenging.…”

Section: Discussionmentioning

confidence: 99%

Multifocal Cutaneous Granular Cell Tumor in Children: A Rare Entity

El‐Khalawany

Rageh

Hassab-El-Naby

2021

The American Journal of Dermatopathology

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Granular cell tumors (GCTs) are rare soft tissue tumors of Schwann cell origin that manifest as papulonodular lesions and occur mainly in adults. The diagnosis is usually confirmed by histopathology. Most of GCTs are benign, but some lesions may exhibit malignant criteria. This study is a retrospective case series including all children with histopathologically documented multiple GCTs who attended the dermatology department of the university hospitals between February 2008 and March 2021. The objective of our study was to raise awareness to this unrecognized and rare entity in such age group. The study included 9 patients (6 girls and 3 boys) with multiple GCTs. Their age ranged between 5 and 13 years. The lesions were skin-colored to light brown, firm, smooth-surfaced nodules. Most of the lesions were on the extremities, and their mean diameter was 160.5 mm 2 . None of the lesions exhibited any malignant criteria on histopathology. No extracutaneous or mucosal lesions were detected. Dermatologists should be aware of this rare condition in children because early recognition allows more conservative resection of the tumor and less invasive reconstruction of the defect. Our study highlights that multifocality does not necessarily indicate malignancy or other systemic comorbidities.

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