Granular Cell Tumor: A Mimicker of Breast Carcinoma

Background: Granular cell tumors (GrCTs) are rare neoplasms derived from Schwann cells and can affect any part of the body. They are histologically categorized into benign (most common), atypical, or malignant (<2%) subtypes.Methods: A retrospective review of pathology-proven GrCTs at a tertiary hospital was done from 4/1/2014 to 3/31/2021. The patient age, gender, location of the tumor, and imaging findings were reviewed.Results: A total of 18 patients with GrCTs were found over a period of 7 years. The sites of involvement ranged from the tongue to the heel. The most common site of occurrence was the esophagus. There were 2 cases of recurrences and 2 cases of multicentric GrCTs. In our study, we did not have atypical or malignant GrCTs. Conclusion: Granular cell tumors are uncommon and primarily published as case reports and case series. Our seven-year review provides a comprehensive synopsis of this tumor in the breast and rest of the body. Their clinical and imaging features are non-characteristic, but histopathologic features with immunohistochemistry are diagnostic. Complete surgical excision with negative margins is the accepted standard of care. A global overview of this tumor will allow physicians to provide their patients with a better understanding of their diagnosis and prognosis.

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“…6,13,21 Its present name, granular cell tumor, is derived from the presence of abundant granular eosinophilic cytoplasm in their cells. 23…”

Section: Discussionmentioning

confidence: 99%

“…2,31,33 Calcifications are rare. 13,23 On ultrasound, they are hypoechoic or heterogeneous, with margins ranging from circumscribed to not circumscribed. 2,31,33 (Figure 6).…”

Section: Granular Cell Tumor In the Breastmentioning

confidence: 99%

Revisiting the Inscrutable Granular Cell Tumors in the Breast and Beyond: An Institutional Experience

et al. 2022

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“…Mammography demonstrates spiculations and architectural distortions [93] usually The current literature on these rare tumors has primarily involved surgical excision, and this is generally accepted as the mainstay of management [77] despite the low risk of malignant transformation [85]. Their natural history is not understood well enough for observation to be recommended.…”

Section: Granular Cell Tumorsmentioning

confidence: 99%

“…Mammography demonstrates spiculations and architectural distortions [93] usually without calcifications. Sacranelo et al reported no calcifications in any GCTs reviewed, suggesting that their presence may contradict the diagnosis [94].…”

Section: Granular Cell Tumorsmentioning

confidence: 99%

Mesenchymal Tumors of the Breast: Fibroblastic/Myofibroblastic Lesions and Other Lesions

et al. 2023

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Mesenchymal breast tumors are a rare and diverse group of tumors that present some of the most challenging cases for multidisciplinary breast cancer teams. As a result of overlapping morphologies and a lack of large-scale studies on these tumors, practices are often heterogeneous and slow to evolve. Herein, we present a non-systematic review that focuses on progress, or lack thereof, in the field of mesenchymal breast tumors. We focus on tumors originating from fibroblastic/myofibroblastic cells and tumors originating from less common cellular origins (smooth muscle, neural tissue, adipose tissue, vascular tissue, etc.).

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“…In 8.5% of cases, it is a solitary, palpable, painless mass in the breast. Malignancy has been reported in 0.5% to 2.0% of cases 21 . A granular cell tumor more frequently occurs in the upper outer quadrant.…”

Section: Granular Cell Tumormentioning

confidence: 99%

Benign breast lesions mimicking malignancy: a pictorial essay

Parada-Gallardo¹,

Preciado-Vargas²,

Amezcua-Galvez³

et al. 2022

JMEXFRI

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Introduction: Some benign breast pathologies have clinical and/or imaging features that mimic malignant disease. This pictorial essay describes the mammographic, digital breast tomosynthesis (DBT), and ultrasound (US) features of breast pathologies with imaging findings suspicious for malignancy and histopathologic confirmation of benignity. Material and Methods: This case series presents women with breast lesions that mimic malignancy. BI-RADS 4 or 5 categories on mammography, DBT, and US were included. The history, clinical manifestations, and histopathologic findings with diagnostic confirmation of inflammatory breast pathology, proliferative breast pathology, or benign breast tumors are described. Results: We evaluated nine cases of breast lesions with suspected malignancy, describing mammography, DBT, and US findings, with clinical and pathologic correlations. Breast abscess, granulomatous mastitis, fat necrosis, stromal fibrosis, sclerosing adenosis, pseudoangiomatous stromal hyperplasia (PASH), tubular adenoma, granular cell tumor, and desmoid-type fibromatosis are presented. The differential diagnoses of the benign pathologies simulating malignancy were based on correlating imaging and clinicopathologic findings. Conclusion: The nine breast pathologies described had no pathognomonic radiologic findings for the diagnosis of benignity. Breast biopsy and histopathologic examination were recommended when features suspicious of malignancy were found on mammography, DBT, and/or US.

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Granular Cell Tumor: A Mimicker of Breast Carcinoma

Abstract: Teaching point: Granular cell tumors are rare soft tissue tumors that may occur in the breast. While almost always benign, they may mimic a malignant tumor both clinically and on imaging.

Cited by 5 publications

References 1 publication

Revisiting the Inscrutable Granular Cell Tumors in the Breast and Beyond: An Institutional Experience

Revisiting the Inscrutable Granular Cell Tumors in the Breast and Beyond: An Institutional Experience

Mesenchymal Tumors of the Breast: Fibroblastic/Myofibroblastic Lesions and Other Lesions

Benign breast lesions mimicking malignancy: a pictorial essay

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