Granular Cell Tumor in the Ascending Colon.

Abstract

edescribe a case of multiple polypoid lesions that occurred in the colon ofa 62-year-old man. Eight of the lesions were demonstrated by barium enema, and five were examined histologically. A small nodule in the submucosa of the ascending colon was histologically identical to granular cell tumor, characterized by nested growth of large tumor cells with ample granular cytoplasm and small round nuclei. Immunohistochemically, the cells were positive for S-100, neuron-specific enolase and vimentin, and negative for a-smooth muscle actin and desmin. (Internal Medicine 34: 657-660, 1995)

Granular cell tumor occurring in the sigmoid colon treated by endoscopic mucosal resection using a transparent cap (EMR-C)

“…In the gastrointestinal tract, it may occur anywhere throughout the tract, and the most common site is the esophagus, followed by the large intestine, in which GCT usually occurs in the anorectal area and the right colon. 5,6 Only three cases of GCT of the sigmoid colon have been reported in Japan. 7 According to Takeyama et al, 7 a review of the Japanese literature revealed 44 cases of GCT in the large intestine in Japan.…”

Granular cell tumor of colon: a case report

“…Diagnosis is rarely difficult at the histopathological analysis, as the presence of nests of large cells with abundant cytoplasm and small and round nucleus is typical. The immunohistochemical analysis confirms the diagnosis when demonstrating positivity to S-100 protein, neuron specific enolasis and vimentin, and negativity to alpha smooth muscle actin and desmin 1 . As this is a benign pathology, the recommended treatment is the endoscopic excision of the lesion by extensive biopsy when the tumor diameter is smaller than 2 cm and not adherent to the muscularis propria, preventing complications such as perforation and bleeding 6 .…”

“…The tumor symptoms are unspecific. In most cases, the lesions are asymptomatic; and they may simulate other pathologies that affect the colon, such as hematochezia and abdominal discomfort 1,7 . At colonoscopy, the aspect is similar to that of a sessile polyp, preferably located in the anorectal area and the ascending colon 4 .…”

Granular Cell Tumor of the Descending Colon Treated by Endoscopic Mucosal Resection: A Case Report and Review of the Literature

“…Johnston et al (6) also reported that 17 of 20 colorectal GCTs were found incidentally during investigations for hemorrhoids or routine medical checkup. In other reports (9, 14), rectal bleeding or a positive fecal occult blood test was described, but it is unlikely that either of these findings was caused by a GCT, which is covered by an intact colonic mucosa without ulceration and inflammation. Colorectal GCTs may be located anywhere between the rectum and the cecum, with a preferential location in the ascending colon and cecum based on the results of our literature review (Table 1).…”