Granular cell tumor of stomach: A case report and review of literature

Abstract

Granular cell tumor (GCT) was described for the first time by Abrikosoff in 1926. It is a relatively rare neoplasm that may occur at many sites, but most commonly in the skin or soft tissues. The occurrence of GCT in the gastrointestinal tract is rare, accounting approximately for 8% of all tumors, among which the most common site is the esophagus, whereas gastric localization is very rare. Gastric GCTs can be solitary or, more frequently, associated with other gastrointestinal localization. Although GCTs are usually clinically and histologically benign, some malignant cases have been reported. Histologically, these tumors consist of polygonal and fusiform cells disposed in compact "nests" and immunohistochemical staining for S-100 protein supports the proposed derivation from Schwann cells. A correct preoperative diagnosis of this tumor can only be made in 50% of all patients and it is always based on endoscopic biopsy. Laparoscopic or conventional wedge resection represents the treatment of choice. In this study, the authors reported a case of a 49-year-old woman with a solitary granular cell tumor of the stomach with infiltrative pattern, successfully treated with surgical resection. A review of literature is also presented with emphasis on diagnostic criteria concerning the malignant form.

Lack of Utility of Cytokeratins in Differentiating Pseudocarcinomatous Hyperplasia of Granular Cell Tumors from Oral Squamous Cell Carcinoma

“…It can occur in almost any part of the human body such as the oral cavity, breast, large intestine and stomach (Lack, et al ,1980;Patti et al, 2006;Huyskens and Geniets 2014;Zhang et al, 2014). For both GCT and oral squamous cell carcinoma (OSCC), the most common growth site in the oral cavity is the tongue (Neville, 2009).…”

A Case of Gastric Granular Cell Tumor: Review of Literature and Features of Endoscopic Ultrasonography

“…6 Conventional endoscopic findings and EUS findings of carcinoid tumors are similar to GCTs, therefore differential diagnosis between GCTs and carcinoid tumors is very difficult. 7 Patti et al 8 reported a case of gastric GCT in 2006, and reviewed 5 cases of gastric GCTs. Since 2006, eleven cases of gastric GCT have been reported.…”

Endoscopic ultrasonography for gastric submucosal lesions

“…Granular cell tumors are usually benign in behavior, although some malignant cases (a single gastric case) have also been reported. Endosonographically they present as a hypoechoic, heterogeneous well-demarcated mass with smooth borders, arising from the second or third wall layer [8,12,13,28] .…”