Granular Cell Tumor of the Pancreas

el-HM, Méklati; Lévy, Philippe; O’Toole, Dermot; Hentic, Olivia; Sauvanet, Alain; Ruszniewski, Philippe; Couvelard, Anne; Mp, Vullierme; Caujolle, B; Palazzo, L.

doi:10.1097/01.mpa.0000178282.58158.bf

Cited by 11 publications

(2 citation statements)

References 5 publications

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“…These findings of MRI in other locations were not fully consistent with our report, and therefore we cannot reach an unified conclusion about the MRI characteristics of GCT to suite for all locations. It has been reported that endoscopic ultrasound- or CT-guide fine-needle aspiration, not the most reliable method, may be helpful in diagnosis of pancreatic GCT[ 21 , 22 ], histopathological testing of the tissue specimen is the gold standard for the final and exact diagnosis. Complete resection of the lesion was the main treatment for our patient, and the prognosis is for him is good.…”

Section: Discussionmentioning

confidence: 99%

Particular tumor of the pancreas: A case report

Zhu¹,

Nie²

2021

WJCC

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BACKGROUND Granular cell tumor (GCT) of the pancreas is a rare neurogenic tumor. The first case of pancreatic GCT was described in 1975, and up to now, only 7 cases have been reported. CASE SUMMARY A 53-year-old male had a pancreatic mass for 1 mo. He was not treated at the local hospital, but referred to Henan Tumor Hospital for surgery. Preoperative imaging revealed a 2.0 cm × 2.5 cm-sized mass located in the body of the pancreas. At the microscopic level, a large number of eosinophilic particles are present in the oval tumor cells. The immunohistochemistry of this tumor cell display CD56 (+), blood vessels CD34 (+), Ki-67 (+) < 10%, and S-100 (+). CONCLUSION GCT of the pancreas should be recognized as a preoperative differential diagnosis of pancreatic tumors. Surgical resection of the tumor should be attempted; however, GCT of the pancreas has a certain rate of tumor metastasis and recurrence. Therefore, GCT of the pancreas requires regular and long-term follow-up.

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Section: Discussionmentioning

confidence: 99%

Particular tumor of the pancreas: A case report

Zhu¹,

Nie²

2021

WJCC

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“…Clinically, this finding is important in counseling patients on future risks and has implications for post-diagnosis screening and monitoring. Combined, less than ten renal 23 and pancreatic [24][25][26][27][28][29][30] granular cell tumors and have been reported in the literature. Though these cases may contribute to the increased incidence of renal and pancreatic cancers observed in patients with malignant cutaneous granular cell tumors, the biological underpinnings of any such relationship has not been explored.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of malignant cutaneous granular cell tumors: A United States population-based cohort analysis using the Surveillance, Epidemiology, and End Results (SEER) database

2018

Journal of the American Academy of Dermatology

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Background-Malignant cutaneous granular cell tumors (mcGCT) are rare and associated with substantial morbidity and mortality. The literature includes single-institution studies.Objective-To examine the incidence, secondary malignancies, treatment, overall survival (OS), and disease-specific survival (DSS) of patients with mcGCT.Methods-A population-based cohort analysis was conducted in the Surveillance, Epidemiology, and End Results (SEER) database, 1973-2013, for patients diagnosed with mcGCT. Risk-adjusted associations between OS/DSS and patient characteristics and treatment modalities were assessed using Cox proportional-hazard regression. Quantile regression determined median survival times.Results-Five-year DSS was 62.8%. Patients demonstrated an increased risk for renal and pancreatic cancers. In risk-adjusted models, male sex (0.21[0.06-0.82]; P=0.02), advanced cancer stage (2.29[1.40-3.72]; P<0.01), and surgical resection (0.06[0.01-0.59]; P=0.02) predicted DSS. Median survival time in years increased for males (1.39), earlier stage (0.60), and surgical intervention (5.34).

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Granular cell tumour of the pancreas: a case report and systematic review

Tree

Kotecha

Mehta

et al. 2023

Langenbecks Arch Surg

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Purpose Granular cell tumours (GCTs) of the pancreas are mostly benign and exceptionally rare, with no unique identifying radiological features. Following a case discussion of a patient with GCT, a comprehensive review of available literature was conducted to identify the common diagnostic features associated with GCT. Methods Following a case report identified in our institution, a systematic review was conducted by two authors in accordance with Preferred Reporting Items for Systematic review and Meta-Analysis protocols (PRISMA) guidelines. Databases MEDLINE, EMBASE, Scopus, World of Science, and grey literature were searched on August 2021. Inclusion criteria were histopathology diagnosed granular cell tumour of the pancreas. Results A 37-year-old male presented with 1 month of abdominal pain and an MRI demonstrating a dilated main pancreatic duct, distal parenchymal atrophy, but no focal lesion. Repeat MRI at 6 months re-demonstrated similar findings and subsequent endoscopic ultrasound was suspicious for main duct IPMN. Following multidisciplinary team discussion, a spleen-preserving distal pancreatectomy was performed. Histopathology demonstrated granular cell tumour with cells diffusely positive for S100 and no malignant transformation. 11 case reports were identified in the literature with diagnosis confirmed on tissue histopathology based on positive immunohistochemical staining for S-100 protein. Eight patients presented with gastrointestinal symptoms with abdominal pain the main presenting complaint (50%). 10 patients underwent CT with portal venous contrast and all underwent endoscopic examination. Imaging findings were similar in five studies for EUS which demonstrated a hypoechoic lesion with homogenous appearance. On non-contrast CT GCT was iso-enhancing, and with portal venous contrast demonstrated hypo-enhancement that gradually enhanced on late phases. Pre-operative diagnosis of pancreatic carcinoma was described in six cases based on imaging and biopsy, resulting in progression to surgical resection. Nine patients were managed surgically and no complications identified on follow-up (6–52 months). Conclusion The currently proposed management pathway includes EUS with biopsy and CT, and surgical resection recommended due to malignancy risk. Improved sample collection with EUS-FNA and microscopic assessment utilising S-100 immunohistochemistry may improve pre-operative diagnosis. Limitations include rare numbers in reported literature and short follow-up not allowing an assessment of GCT’s natural history and malignancy risk. Additional cases would expand the current dataset of GCTs of the pancreas, so that surgical resection may be avoided in the future.

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Granular Cell Tumor of the Pancreas

Cited by 11 publications

References 5 publications

Particular tumor of the pancreas: A case report

Particular tumor of the pancreas: A case report

Epidemiology of malignant cutaneous granular cell tumors: A United States population-based cohort analysis using the Surveillance, Epidemiology, and End Results (SEER) database

Granular cell tumour of the pancreas: a case report and systematic review

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