Granular cell tumor of the penis: clinicopathologic evaluation of 9 cases

Laskin, William B.; Fetsch, John F.; Davis, Charles J.; Sesterhenn, Isabell A.

doi:10.1016/j.humpath.2004.12.011

Cited by 30 publications

(17 citation statements)

References 34 publications

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“…We are aware of only one case of granular cell tumor located on the penis, where vascular invasion was documented on hematoxylin and eosin slides, and the tumor behaved in a benign fashion [18]. The small series of penile granular cell tumors including the case with invasion of a vessel (more precisely the vascular wall as depicted in Figure 1B of the publication) also suggested that minor involvement of the surgical margins did not obviously result in local recurrences, and, given the problematic nature of reexcision at that anatomic location, follow-up could also be a reasonable first choice as clinical decision [18].…”

Section: Discussionmentioning

confidence: 99%

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Vascular invasion demonstrated by elastic stain—a common phenomenon in benign granular cell tumors

Sejben

2008

Virchows Arch

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Granular cell tumor is generally benign, but rare malignant cases have been documented. Features of malignancy include necrosis, cellular spindling, vesicular nuclei with large nucleoli, increased mitotic activity, high nuclear to cytoplasmic ratio, and pleomorphism, but not vascular invasion. Venous invasion was incidentally identified with the orcein elastic stain in an otherwise benign granular cell tumor (propositus case). Four further benign granular cell tumors were also analyzed; venous invasion was discovered in three. It is suggested that vascular invasion is not uncommon in granular cell tumors and should not lead to the classification of the tumor as malignant or atypical. It is likely that in most cases there is only invasion of the vascular wall. It is also suggested that some cases of vascular invasion identified by elastic stains in tumors such as colorectal carcinomas (where these stains are recommended for routine use) may also represent invasion of vascular structures without the propensity of metastasis.

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Section: Discussionmentioning

confidence: 99%

“…It seems likely that the instances of vascular invasion are related to the invasive growth pattern of granular cell tumors. Similarly to small nerve invasion [3,18,19], the tumor cells may simply grow through the vessel wall as well, without a real propensity to metastasize.…”

Section: Discussionmentioning

confidence: 99%

Vascular invasion demonstrated by elastic stain—a common phenomenon in benign granular cell tumors

Sejben

2008

Virchows Arch

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“…Immunohistochemical stain assessment of the granular cells Immunoreactivity was semiquantitatively scored according to the method of Laskin et al [30]: 0 = no detectable immunoreactivity, 1 = 1-10% of the tumor cells are reactive, 2 = 11-25% of the tumor cells are reactive, 3 = 26-50% of the tumor cells are reactive, and 4 = >50% of the tumor cells are reactive. In addition, immunoreactivity was graded according to the staining intensity as performed by Williams and Williams [31] and Fine and Li [32]: '-' = negative, '+' = weak; '++' = moderate, and '+++' = strong.…”

Section: Methodsmentioning

confidence: 99%

Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult

2009

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Congenital granular cell epulis (CGCE), a rare benign lesion arising from the mucosa of the alveolar ridges of the jaws in newborns, has a clinical course characterized by lack of further growth after birth. Histomorphologically, it resembles a granular cell tumor (GCT) of the adult. The histogenesis of this lesion is unclear. We submitted a series of five CGCEs to a large panel of antibodies in order to trace the origin of the constituent granular cells. The resultant immunohistochemical profile showed positivity of these cells to vimentin, NKI/C3, and PGP9.5. This does not confirm any particular cell type for the histogenetic origin of CGCE but may rather reflect a local metabolic or reactive change, providing supporting evidence that the lesion is of a non-neoplastic nature. In addition, the granular cells were non-reactive for S-100, NGFR/p75, and inhibin-alpha, which further contributes to the distinction between a CGCE and the adult GCT.

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“…Laskin et al 35 described the clinicopathologic characteristics of 9 unusual cases of GCT occurring in penile tissue, 2 of which demonstrated PNI. In one of the cases demonstrating PNI, the patient carried the concomitant diagnosis of Peyronie disease.…”

Section: Granular Cell Tumormentioning

confidence: 99%

Perineural Involvement: What Does it Mean?

Ronaghy

Yaar²,

Goldberg³

et al. 2010

The American Journal of Dermatopathology

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Perineural invasion is an important mechanism for local spread in certain malignant cutaneous neoplasms and is associated with aggressive tumor growth, increased frequency of recurrence, and increased morbidity and mortality. Thus, perineural invasion is often used both as a marker of malignancy and an indicator of aggressive behavior. There exists, however, a limited number of cutaneous and noncutaneous benign neoplasms in addition to reactive lesions that either demonstrates perineural involvement or mimics it. Given the association of the term "invasion" with malignant neoplasms, we use the term "perineural involvement" to describe neoplastic cells of any type infiltrating within nerves. Despite the presence of perineural involvement in these benign lesions, there is no evidence of aggressive behavior compared with similar examples which do not demonstrate perineural involvement. The aim of this article is to review cutaneous and noncutaneous benign neoplasms and reactive conditions that may demonstrate or mimic perineural involvement. Recognition of the spectrum of benign processes that may resemble perineural involvement may help prevent diagnostic confusion, misdiagnosis, and overly aggressive treatment.

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Granular cell tumor of the penis: clinicopathologic evaluation of 9 cases

Cited by 30 publications

References 34 publications

Vascular invasion demonstrated by elastic stain—a common phenomenon in benign granular cell tumors

Vascular invasion demonstrated by elastic stain—a common phenomenon in benign granular cell tumors

Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult

Perineural Involvement: What Does it Mean?

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