Granular cell tumours revisited. An immunohistological and ultrastructural study

Buley, I; Gatter, Kevin C.; Kelly, P. M.; Heryet, A; Millard, P.R.

doi:10.1111/j.1365-2559.1988.tb01941.x

Cited by 101 publications

(58 citation statements)

References 27 publications

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“…However, several other investigators have reported negative staining for GFAP in the tumor, which constitutes evidence against a pituicyte origin [9,15,17,21]. A third hypothesis, which is endorsed by some authors, including us, believes that, due to the variable immunoreactivity, these tumors are biologically heterogeneous in spite of histological homogeneity [4,26].…”

Section: Discussionmentioning

confidence: 74%

“…These tumors were initially believed to be an aberrant growth of embryological tissue and were called "choristomas" [11]. Later, the term "granular myoblastoma" was suggested because of the similarity to the GCTs of the tongue originally considered to be derived from embryonic muscle cells [4,12,13]. There is, however, no evidence that these neurohypophysial tumors originate from muscle cells [14], due to their negativity for immunoperoxidase staining for desmin and smooth muscle actin.…”

Section: Discussionmentioning

confidence: 99%

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Granular cell tumor of the neurohypophysis: report of a case with unusual age presentation

et al. 2005

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Granular cell tumor (GCT) usually occurs as a solitary, small, nodular tumor and rarely grows to a sufficient size to present symptoms. The tumor is more prevalent in female adults. The authors report a case of an 8-year-old boy with GCT of the neurohypophysis presenting with central precocious puberty. Few cases of symptomatic GCT have been reported in the literature, none of them in a patient in the first decade of life. Clinical picture, histopathological features, and histogenesis of GCT of neurohypophysis are discussed.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Granular cell tumor of the neurohypophysis: report of a case with unusual age presentation

et al. 2005

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“…[34] Some authors support a peripheral nerve-related cells origin for the majority of GCTs based on the finding of cytoplasmic granules with numerous membrane-bound vacuoles (which contain myelin-like tubules) and indicating some relationships with pre-existent axons. [30,35,36] It is also to be remembered that granular cell populations have been described in some nonneural neoplasms of the oral cavity such as ameloblastoma, ameloblastic fibroma, odontogenic fibroma, odontogenic cysts, and oral lichen planus. [37,38] Although, these tumors are S100-negative, in contrast to the classic GCT.…”

Section: Kaustuv Das Biswas Et Al Present Case 12years-tongue 2014mentioning

confidence: 99%

GRANULAR CELL TUMOR OF TONGUE IN A 12 YEAR OLD GIRL: A CASE REPORT & REVIEW OF LITERATURE

Sen¹,

Ghatak²,

Dutta³

et al. 2014

jemds

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Granular cell tumor (GCT) or Abrikossoff's tumor, variously termed as myoblastoma, granular cell neurofibroma or granular cell schwannoma, is a rare entity, with a reported prevalence ranging from 0.019% to 0.03% of all human neoplasms. It can occur in any region of the body or soft tissues of any organ. It has been found that GCTs of the oral cavity can occur both in pediatric and advanced age, but their incidence usually peaks between the fourth and the sixth decade, while their occurrence before the age of 20 years is very rare. Here we represent a case of GCT affecting tongue of a 12 year old girl, which is a rare occurrence. Clinical & histopathological features have been discussed, also mentioning presence & distribution of immunohistochemical markers & a brief review of recent literature.

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“…The granular cell tumors show immunoreactivity for S-100 protein (Fig. 3), vimentin, neuron-specific enolase (NSE), CD68 and CD57 [6] [7]. We used the following monoclonal primary antibodies: anti-CD68 (PG-M1, prediluited; DAKO, Carpinteria, CA, USA), anti-CD57 (QBEND-10, DAKO, Carpinteria, CA, USA) and S-100 protein (polyclonal, prediluited, Dako).…”

Section: Case Presentationmentioning

confidence: 99%

Granular Cell Tumour of the Tongue in a 8-Year-Old Boy: A Case Report

Russo¹

2011

TOOTORJ

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Granular cell tumor is a relatively uncommon benign neoplasm that occurs in almost any part of the body, with the head and neck region involved in 45 to 65% of the cases. The peak of incidence is generally in the fourth to sixth decades of life, while it is very rarely encountered in children. Usually, it appears as a singular nodular mass covered by intact overlying mucosa. Its etiology and histogenesis is unclear; in addition, its nature is sometimes questioned due to the occurrence of malignancy in less than 2% of all lesions, and/or recurrence or metastasis to regional lymph nodes despite a benign histopathological appearance.In the present paper, we describe a case with intraoral location occurred in a child, whose clinical and immunohistopathological features seem to confirm a benign course of tumor even in the childhood.

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Granular cell tumours revisited. An immunohistological and ultrastructural study

Cited by 101 publications

References 27 publications

Granular cell tumor of the neurohypophysis: report of a case with unusual age presentation

Granular cell tumor of the neurohypophysis: report of a case with unusual age presentation

GRANULAR CELL TUMOR OF TONGUE IN A 12 YEAR OLD GIRL: A CASE REPORT & REVIEW OF LITERATURE

Granular Cell Tumour of the Tongue in a 8-Year-Old Boy: A Case Report

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