1983
DOI: 10.1111/j.1600-0714.1983.tb00310.x
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Granular cells associated with the enamel organ of a developing tooth

Abstract: An accumulation of granular cells associated with the enamel organ of a developing deciduous, incisor tooth was noted during light microscopy (LM) of serial sections from the right half of a mandible from a stillborn, female infant of 37 weeks gestations. There was a break in continuity of the enamel matrix associated with the focus of granular cells, which appeared to be continuous with, and arise directly from, the cells of the stratum intermedium. The granular cells were very similar histologically to those… Show more

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Cited by 11 publications
(5 citation statements)
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“…In The overall histological features of granular cells in our odontoma are more like those of pericoronal histiocytic aggregates as described above (25). No transition between granular cells and tooth germ mitigates against an odontogenic origin as proposed by Sunderland et al (23). An apparent chronic inflammatory infiltrate scattered throughout the granular cell nodule supports the histiocytic origin.…”
Section: Introductionsupporting
confidence: 75%
“…In The overall histological features of granular cells in our odontoma are more like those of pericoronal histiocytic aggregates as described above (25). No transition between granular cells and tooth germ mitigates against an odontogenic origin as proposed by Sunderland et al (23). An apparent chronic inflammatory infiltrate scattered throughout the granular cell nodule supports the histiocytic origin.…”
Section: Introductionsupporting
confidence: 75%
“…Accumulation of granular cells is also noted in enamel organ of deciduous tooth. [ 11 ] This may be due to lysosomal insufficiency or overproduction of unused material in the odontogenic epithelium. Thus, odontogenic epithelium seems to be capable of undergoing granular change under certain conditions.…”
Section: Discussionmentioning
confidence: 99%
“…During normal amelogenesis, an increase in the autophagic lysosomes has been observed in the ameloblasts between secretory and absorptive stages and from reduced ameloblasts to squamous epithelium. Accumulation of granular cells is also noted in enamel organ of deciduous tooth [1]. This may be due to lysosomal insufficiency or overproduction of unused material in the odontogenic epithelium.…”
Section: Granular Cell Ameloblastoma (Gca)mentioning
confidence: 93%
“…The nature of various oral granular cell lesions is unclear, and many theories have been proposed for the origin of granules, the principal ones are odontogenic, fibroblastic, histiocytic, myoblastic, and neurogenic. Granular cells are also seen associated with the enamel organ of developing tooth [1].…”
Section: Introductionmentioning
confidence: 92%